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A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between ?-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydanto
A second-generation synthesis of (-)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe3cae557dbd4db01e74600759508a1
https://eprints.soton.ac.uk/392805/
https://eprints.soton.ac.uk/392805/
Publikováno v:
ChemInform. 45
A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between ?-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydanto