B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates

Autor: Hossain, Md. Alamgir, Anasti, Kara, Watts, Brian, Cronin, Kenneth, Derking, Ronald, Groschel, Bettina, Kane, Advaiti Pai, Edwards, R.J., Easterhoff, David, Zhang, Jinsong, Rountree, Wes, Ortiz, Yaneth, Saunders, Kevin, Schief, William R., Sanders, Rogier W., Verkoczy, Laurent, Reth, Michael, Alam, S. Munir

Publikováno v: In Cell Reports 28 June 2022 39(13)

The CH1 domain influences the expression and antigen sensing of the HIV-specific CH31 IgM-BCR and IgG-BCR.

Autor: Ortiz Y; Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, Freiburg 79104, Germany.; Faculty of Biology, Signalling Research Centers Centre for Integrative Biological Signalling Studies and Centre for Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany., Anasti K; Department of Medicine & Pathology, Human Vaccine Institute, Duke University, Durham, NC 27703., Kane AP; Department of Medicine & Pathology, Human Vaccine Institute, Duke University, Durham, NC 27703., Cronin K; Department of Medicine & Pathology, Human Vaccine Institute, Duke University, Durham, NC 27703., Alam SM; Department of Medicine & Pathology, Human Vaccine Institute, Duke University, Durham, NC 27703.; Deparment of Medicine and Pathology, Duke University, Durham NC 27703., Reth M; Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, Freiburg 79104, Germany.; Faculty of Biology, Signalling Research Centers Centre for Integrative Biological Signalling Studies and Centre for Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 30; Vol. 121 (31), pp. e2404728121. Date of Electronic Publication: 2024 Jul 23.