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Akademický článek

Epidemiología de las dermatomicosis en 30 años de estudio en el Instituto de Medicina Tropical Daniel A Carrión, Universidad Nacional Mayor de San Marcos, Lima, Perú

Autor: Vilma Bejar, Freddy Villanueva, José María Guevara, Sofía González, Germán Vergaray, Enma Abanto, Kandy Napán, Luis Velasque, Silvana Vergaray

Publikováno v: Anales de la Facultad de Medicina, Vol 75, Iss 2, Pp 167-172 (2014)

Objetivos: Determinar la evolución epidemiológica de las dermatomicosis en pacientes de consultorio externo durante el periodo 1976- 2005. Diseño: Estudio descriptivo, retrospectivo y analítico. Lugar: Instituto de Medicina Tropical ‘Daniel Alc

Externí odkaz: https://doaj.org/article/c1f116a16a954393827c2fb1157cd06a

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Transcriptional changes consistent with impaired neuronal differentiation, angiogenesis, and tumor plasticity induced in human subpallial telencephalic organoid-glioblastoma chimeras

Autor: Simone Chiola, Jingye Yang, H M Arif Ullah, Kandy Napan, Qiju Huang, Nicholas Gamboa, Osama Youssef, Howard Colman, Samuel H. Cheshier, Alex Shcheglovitov

Glioblastoma multiforme (GBM) is one of the most aggressive and therapy-resistant brain tumors prevalent in both adults and children. Despite extensive research to understand GBM pathology, it remains unclear how neural cells in the human brain inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::499291105bf8b554f2504b0e6429af31
https://doi.org/10.1101/2023.05.11.540229

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New insights into pradimicin biosynthesis revealed by two O-methyltransferases

Autor: Tyler Gladwin, Jon Y. Takemoto, Fuchao Xu, Kandy Napan, Jixun Zhan, Shuwei Zhang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 27:3499-3502

Pradimicins are a group of antiviral and antifungal natural products from Actinomadura hibisca. Two putative O-methyltransferase genes, pdmF and pdmT, are present in the pradimicin biosynthetic gene cluster. However, there is only one methoxy group (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edad54fa09d26eec62e6dd561c20318
https://doi.org/10.1016/j.bmcl.2017.05.068

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Epidemiology of dermatomycoses in 30 years of study at Daniel a Carrion Institute of Tropical Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru

Autor: Luis Velasque, Freddy Villanueva, Sofía González, Kandy Napan, José M. Guevara, Germán Vergaray, Vilma Béjar, Enma Abanto, Silvana Vergaray

Publikováno v: Anales de la Facultad de Medicina, Vol 75, Iss 2, Pp 167-172 (2014)
Redalyc
Anales de la Facultad de Medicina, Volume: 75, Issue: 2, Pages: 167-172, Published: APR 2014
Anales de la Facultad de Medicina; Vol 75 No 2 (2014); 167-172
Anales de la Facultad de Medicina; Vol. 75 Núm. 2 (2014); 167-172

Objetivos: Determinar la evolución epidemiológica de las dermatomicosis en pacientes de consultorio externo durante el periodo 1976-2005. Diseño: Estudio descriptivo, retrospectivo y analítico. Lugar: Instituto de Medicina Tropical ‘Daniel Alci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63defe453229445e0775dba0977b499
http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1025-55832014000200013&lng=en&tlng=en

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A key cytochrome P450 hydroxylase in pradimicin biosynthesis

Autor: Kandy Napan, Jixun Zhan, Jia Zeng, Jon Y. Takemoto

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:606-609

Pradimicins A-C (1–3) are a group of antifungal and antiviral polyketides from Actinomadura hibisca. The sugar moieties in pradimicins are required for their biological activities. Consequently, the 5-OH that is used for glycosylation plays a criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b807fc3d611c7dade9f9743de6b69fa9
https://doi.org/10.1016/j.bmcl.2011.10.075

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Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties

Autor: Shuwei Zhang, Jon Y. Takemoto, Kandy Napan, Jixun Zhan, Thomas Anderson

Publikováno v: Bioorganicmedicinal chemistry letters. 25(6)

Pradimicins are antifungal and antiviral natural products from Actinomadura hibisca P157-2. The sugar moieties play a critical role in the biological activities of these compounds. There are two glycosyltransferase genes in the pradimicin biosyntheti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3fbb8ece4876fb4db4c81a1295b966
https://pubmed.ncbi.nlm.nih.gov/25677666

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Synergistic Actions of Tailoring Enzymes in Pradimicin Biosynthesis

Autor: Jon Y. Takemoto, Shuwei Zhang, Thomas Anderson, Kandy Napan, Jixun Zhan, Whitney Morgan

Three key tailoring enzymes in pradimicin biosynthesis: PdmJ, PdmW, and PdmN, were investigated. PdmW was characterized as the C-6 hydroxylase by structural characterization of the corresponding product, 6-hydroxy-G-2A. The efficiencies of the C-5 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44943c03c1f6f03635057e7ca6d5b4f9
https://europepmc.org/articles/PMC4214279/

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