Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kandula S. R. Sastry"'
Autor:
Kandula S. R. Sastry
Publikováno v:
Medical Physics. 19:1361-1370
The biological implications of Auger electron cascades following inner shell ionization of atoms have been of interest for over 25 years. By virtue of their decay via orbital electron capture and/or internal conversion, several biomedical radionuclid
Publikováno v:
Radiation Protection Dosimetry. 31:325-328
A daughter product of 226Ra, 210Po, emits 5.3 MeV a particles. The kinetics of uptake, retention, and cytotoxicity of 210Po-citrate have been studied in Chinese hamster V79 cells. The survival of V79 cells is exponentially dependent on the absorbed d
Publikováno v:
Radiation Protection Dosimetry. 31:329-332
Using spermatogenesis in the mouse testis as the experimental model, we have investigated the in vivo effects of 5.3 MeV a particles in the decay of 210Po localised in the organ. Spermatogonial cell killing and induction of abnormal shapes in epididy
Autor:
Venkat Narra, S. Murty Goddu, Kandula S. R. Sastry, Dandamudi V. Rao, Roger W. Howell, Sven-Erik Strand
Publikováno v:
Medical physics. 21(12)
The radiotoxicity of three 99mTc-labeled compounds is investigated using spermatogenesis in mouse testis as the experimental model, and spermatogonial cell survival as the biological end point. The radiopharmaceuticals studied are pertechnetate (99mT
Publikováno v:
Radiation Research. 140:276
The radiochemical dipyrrolidinedithiocarbamato-212Pb(II) [212Pb(PDC)2] is synthesized and its effects on colony formation in cultured Chinese hamster V79 cells are investigated. The cellular uptake, biological retention, subcellular distribution and
Autor:
R. N. Hamm, Stephen Adelstein, Amin I. Kassis, Harvel Wright, Kandula S. R. Sastry, Roger W. Howell, Dandamudi V. Rao, James E. Turner
Publikováno v:
Radiation Research. 140:55
The chemotoxicity and radiotoxicity of trans-dichlorodiammineplatinum (II) labeled with 195mPt (trans-195mPt) are investigated to ascertain the potential of radioplatinum coordination complexes as antineoplastic agents. Platinum-195m, with a half-lif
Publikováno v:
Radiation Research. 137:394
The potential of vitamin C, an antioxidant, to protect the radiosensitive spermatogonial cells in mouse testes against the effects of chronic irradiation by radionuclides incorporated into tissue was investigated. Interestingly, when injected intrate
Publikováno v:
Radiation Research. 134:256
Publikováno v:
Radiation Research. 134:71
Radionuclides that emit Auger electrons are widely used in nuclear medicine (e.g., 99mTc, 123I, 201Tl) and biomedical research (e.g., 51Cr, 125I), and they are present in the environment (e.g., 40K, 55Fe). Depending on the subcellular distribution of
Publikováno v:
Radiation Research. 128:282
The problem of determining RBE values for Auger emitters incorporated into proliferating mammalian cells is examined. In general, the reference radiation plays a key role in obtaining experimental RBE values. Using survival of cultured Chinese hamste