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Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease.

Autor: Salian VS; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Tang X; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Thompson KJ; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Curan GL; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Lowe VJ; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Li L; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Kalari KR; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.)., Kandimalla KK; Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.) kkandima@umn.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 Nov 19; Vol. 391 (3), pp. 430-440. Date of Electronic Publication: 2024 Nov 19.

Amyloid PET detects the deposition of brain Aβ earlier than CSF fluid biomarkers.

Autor: Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Mester CT; Departments of Radiology and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Lundt ES; Departments of Radiology and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Lee J; Department of Biomedical Engineering, College of Medicine, Hanyang University, Seoul, Republic of Korea., Ghatamaneni S; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Algeciras-Schimnich A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Campbell MR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Nguyen A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Min HK; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Senjem ML; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.; Department of Information Technology, Mayo Clinic, Rochester, Minnesota, USA., Machulda MM; Department of Psychology, Mayo Clinic, Rochester, Minnesota, USA., Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Kandimalla KK; Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota, USA., Kantarci K; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Boeve B; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Jones DT; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Knopman D; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Mielke MM; Department of Epidemiology and Prevention at Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 8097-8112. Date of Electronic Publication: 2024 Oct 11.