Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kandice Tanner"'
Autor:
Jerry Xiao, Joseph R. McGill, Apsra Nasir, Alexander Lekan, Bailey Johnson, Devan J. Wilkins, Gray W. Pearson, Kandice Tanner, Hani Goodarzi, Eric Glasgow, Richard Schlegel, Seema Agarwal
Publikováno v:
Molecular Biomedicine, Vol 3, Iss 1, Pp 1-16 (2022)
Abstract Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer metastasis frequently fail to demonstrate efficacy in clinical trials despite strong preclinical e
Externí odkaz:
https://doaj.org/article/92efc3d65a684014a4ffc01a3f56844d
Autor:
Minsuk Kong, Domenico D’Atri, Maria Teresa Bilotta, Bailey Johnson, Taylor B. Updegrove, Devorah L. Gallardo, Federico Machinandiarena, I-Lin Wu, Maira Alves Constantino, Stephen M. Hewitt, Kandice Tanner, David J. Fitzgerald, Kumaran S. Ramamurthi
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111955- (2023)
Summary: Delivery of cancer therapeutics to non-specific sites decreases treatment efficacy while increasing toxicity. In ovarian cancer, overexpression of the cell surface marker HER2, which several therapeutics target, relates to poor prognosis. We
Externí odkaz:
https://doaj.org/article/98972d43a4eb4818a8c6cb579f199029
Autor:
Robert W. Robey, Andrea N. Robinson, Fatima Ali-Rahmani, Lyn M. Huff, Sabrina Lusvarghi, Shahrooz Vahedi, Jordan M. Hotz, Andrew C. Warner, Donna Butcher, Jennifer Matta, Elijah F. Edmondson, Tobie D. Lee, Jacob S. Roth, Olivia W. Lee, Min Shen, Kandice Tanner, Matthew D. Hall, Suresh V. Ambudkar, Michael M. Gottesman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2). However, little information is available regarding ATP-binding cassette transpo
Externí odkaz:
https://doaj.org/article/d695e11725554b04bae4d6fdca65d5b1
Autor:
Kandice Tanner
Publikováno v:
APL Bioengineering, Vol 2, Iss 3, Pp 031801-031801-14 (2018)
Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors
Externí odkaz:
https://doaj.org/article/bcfc0cdc08d24c6fa54a64cec7845461
Autor:
Benjamin L Ricca, Gautham Venugopalan, Saori Furuta, Kandice Tanner, Walter A Orellana, Clay D Reber, Douglas G Brownfield, Mina J Bissell, Daniel A Fletcher
Publikováno v:
eLife, Vol 7 (2018)
Non-malignant breast epithelial cells cultured in three-dimensional laminin-rich extracellular matrix (lrECM) form well organized, growth-arrested acini, whereas malignant cells form continuously growing disorganized structures. While the mechanical
Externí odkaz:
https://doaj.org/article/2be836ae697444c583ceecbf98400827
Publikováno v:
Cell. 186:1792-1813
Autor:
Udochi F, Azubuike, Kandice, Tanner
Publikováno v:
Trends in Cancer. 9:188-197
Metastasis remains the leading cause of cancer lethality. The 'seed/soil' hypothesis provides the framework to explain this cancer phenomenon where the concept of organotropism has been in part mechanistically explained by the properties of the tumor
Publikováno v:
Biophysical Journal. 121:3586-3599
The mechanical phenotype of the cell is critical for survival following deformations due to confinement and fluid flow. One idea is that cancer cells are plastic and adopt different mechanical phenotypes under different geometries that aid in their s
Autor:
Kandice Tanner
Publikováno v:
Journal of Cell Biology. 222
Focal adhesions (FAs) dynamics regulate single cell migration. In this issue, Xue et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202206078) show that Y118 phosphorylation on Paxilin, a key FA protein, limits migration of cells in vivo. Unphos
Publikováno v:
Nature Methods. 20:770-770