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SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease.

Autor: Jesudason, Cynthia D., Mason, Emily R., Chu, Shaoyou, Oblak, Adrian L., Javens‐Wolfe, June, Moussaif, Mustapha, Durst, Greg, Hipskind, Philip, Beck, Daniel E., Dong, Jiajun, Amarasinghe, Ovini, Zhang, Zhong‐Yin, Hamdani, Adam K., Singhal, Kratika, Mesecar, Andrew D., Souza, Sarah, Jacobson, Marlene, Salvo, Jerry Di, Soni, Disha M., Kandasamy, Murugesh

Publikováno v: Alzheimer's & Dementia: Translational Research & Clinical Interventions; Oct2023, Vol. 9 Issue 4, p1-13, 13p

A target enablement package for modulating the activity of PLCγ2 as a therapeutic strategy for the treatment of Alzheimer's disease.

Autor: Clayton, Brent, Bissel, Stephanie J, Richardson, Timothy I, Massey, Steven M, Beck, Daniel E, Putt, Karson S, Bedford, Logan M, Utsuki, Tada, Visvanathan, Ramya, Mesecar, Andrew D, Lendy, Emma K, Kaiser, Bridget L, Chu, Shaoyou, Mason, Emily R, Quinney, Sara K, Kandasamy, Murugesh, Masters, Andrea R, Lamb, Bruce T, Palkowitz, Alan D, Sondek, John

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 21, Vol. 19 Issue 21, p1-2, 2p

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SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease.

Autor: Jesudason CD; Lgenia Fortville Indiana USA., Mason ER; Indiana University School of Medicine Indianapolis Indiana USA., Chu S; Indiana University School of Medicine Indianapolis Indiana USA., Oblak AL; Indiana University School of Medicine Indianapolis Indiana USA.; Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis Indiana USA., Javens-Wolfe J; Indiana Biosciences Research Institute Indianapolis Indiana USA., Moussaif M; Indiana Biosciences Research Institute Indianapolis Indiana USA., Durst G; Lgenia Fortville Indiana USA., Hipskind P; Lgenia Fortville Indiana USA., Beck DE; Institute for Drug Discovery Purdue University West Lafayette Indiana USA., Dong J; Department of Medicinal Chemistry and Molecular Pharmacology Purdue University West Lafayette Indiana USA., Amarasinghe O; Department of Medicinal Chemistry and Molecular Pharmacology Purdue University West Lafayette Indiana USA., Zhang ZY; Institute for Drug Discovery Purdue University West Lafayette Indiana USA.; Department of Medicinal Chemistry and Molecular Pharmacology Purdue University West Lafayette Indiana USA., Hamdani AK; Department of Biochemistry Purdue University West Lafayette Indiana USA., Singhal K; Department of Biochemistry Purdue University West Lafayette Indiana USA., Mesecar AD; Department of Biochemistry Purdue University West Lafayette Indiana USA., Souza S; Evotec Princeton New Jersey USA., Jacobson M; Evotec Princeton New Jersey USA., Salvo JD; Evotec Princeton New Jersey USA., Soni DM; Indiana University School of Medicine Indianapolis Indiana USA., Kandasamy M; Indiana University School of Medicine Indianapolis Indiana USA., Masters AR; Indiana University School of Medicine Indianapolis Indiana USA., Quinney SK; Indiana University School of Medicine Indianapolis Indiana USA., Doolen S; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Huhe H; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Rizzo SJS; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Lamb BT; Indiana University School of Medicine Indianapolis Indiana USA.; Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis Indiana USA., Palkowitz AD; Indiana University School of Medicine Indianapolis Indiana USA.; Indiana Biosciences Research Institute Indianapolis Indiana USA., Richardson TI; Indiana University School of Medicine Indianapolis Indiana USA.; Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis Indiana USA.; Indiana Biosciences Research Institute Indianapolis Indiana USA.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2023 Nov 17; Vol. 9 (4), pp. e12429. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).