Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kandarp M. Dave"'
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231597 (2020)
Resident microglia of the central nervous system are being increasingly recognized as key players in diseases such as neuropathic pain. Biochemical and behavioral studies in neuropathic pain rodent models have documented compelling evidence of the cr
Externí odkaz:
https://doaj.org/article/9dce1e83338c4c578c3381aac5266bf4
Publikováno v:
AAPS PharmSciTech. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57604b4083b8f56c2be1cb878a7b61c7
https://doi.org/10.1208/s12249-023-02526-7
https://doi.org/10.1208/s12249-023-02526-7
Autor:
Uma R. Chandran, Duncan X. Dobbins, Michael Reynolds, Courtney Sabatelle, Sruti Shiva, Yashika S. Kamte, Kandarp M. Dave, Nidia Quillinan, Anisha D'Souza, Amelia Burch, Devika S. Manickam, Wanzhu Zhao, Paco S. Herson, Vishal Soman, Aravind Sreeram, Gina M. Joy
Publikováno v:
J Control Release
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer polarized mitochondria to recipient BECs in culture and to neurons in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48acab122f89221af6ab12e6fea4abd
https://doi.org/10.1016/j.jconrel.2021.08.038
https://doi.org/10.1016/j.jconrel.2021.08.038
Autor:
Kandarp M. Dave, Duncan X. Dobbins, Maura N. Farinelli, Abigail Sullivan, Jadranka Milosevic, Donna B. Stolz, Jeongyun Kim, Siyang Zheng, Devika S. Manickam
Publikováno v:
Cellular and molecular bioengineering. 15(5)
Extracellular vesicles (EVs) are promising carriers for the delivery of biotherapeutic cargo such as RNA and proteins. We have previously demonstrated that the innate EV mitochondria in microvesicles (MVs), but not exosomes (EXOs) can be transferred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa52a66c4feb3488c8e6fc66c154339
https://pubmed.ncbi.nlm.nih.gov/36444353
https://pubmed.ncbi.nlm.nih.gov/36444353
Autor:
Kandarp M. Dave, Donna B. Stolz, Venugopal R. Venna, Victoria A. Quaicoe, Michael E. Maniskas, Michael John Reynolds, Riyan Babidhan, Duncan X. Dobbins, Maura N. Farinelli, Abigail Sullivan, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K. Leak, Sruti S. Shiva, Louise D. McCullough, Devika S Manickam
Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain barrier (BBB). We harnessed the innate mitochondrial load of endothelial cell-derived extracellular vesicles (EVs) and utilized mixtures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bd9baa88f4bdee3a273561f9c25437
https://doi.org/10.1101/2021.10.29.466491
https://doi.org/10.1101/2021.10.29.466491
Publikováno v:
Advanced drug delivery reviews. 171
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier (BBB) are emerging as a dynamic factor in the response to neurolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f794b21df63857ceab0c3984c2ad1bb3
https://pubmed.ncbi.nlm.nih.gov/33497734
https://pubmed.ncbi.nlm.nih.gov/33497734
Autor:
Meredith A. Jackson, Linjiang Han, Lindsay Kadlecik, Kandarp M. Dave, Devika S. Manickam, Craig L. Duvall
Publikováno v:
Pharm Res
PURPOSE: We tested polyplexes of a diblock polymer containing a pH-responsive, endosomolytic core (dimethylaminoethyl methacrylate and butyl methacrylate; DB) and a zwitterionic Poly (methacryloyloxyethyl phosphorylcholine) (PMPC) corona for the deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c56cfe56cb7c343ebdc6ed44c2d6d82
https://doi.org/10.1007/s11095-020-02899-5
https://doi.org/10.1007/s11095-020-02899-5
Extracellular Vesicles Derived from a Human Brain Endothelial Cell Line Increase Cellular ATP Levels
Publikováno v:
AAPS PharmSciTech
Engineered cell-derived extracellular vesicles (EVs) such as exosomes and microvesicles hold immense potential as safe and efficient drug carriers due to their lower immunogenicity and inherent homing capabilities to target cells. In addition to inna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d246ca818c51ca150027e2637826f973
https://pubmed.ncbi.nlm.nih.gov/33389284
https://pubmed.ncbi.nlm.nih.gov/33389284
Autor:
Mohammed Riyazuddin, Anees A. Syed, Zakir Hossain, Jiaur R. Gayen, Shibani Lahiri, Athar Husain, Kandarp M. Dave, Anand P. Gupta, Guru R. Valicherla
Publikováno v:
Peptides. 120
Increase in the prevalence of insulin resistance (IR) in peri-/post-menopause women is mainly due to hormone deficiency and lifestyle. PSTi8 (PEGKGEQEHSQQKEEEEEMAV-amide) is a pancreastatin inhibitor peptide which showed potent antidiabetic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccc9b8957891ad678728c61d0582ed3
https://pubmed.ncbi.nlm.nih.gov/31473204
https://pubmed.ncbi.nlm.nih.gov/31473204
Publikováno v:
The Journal of Pain. 22:589
Lipid nanoparticles (LNPs) are a clinically approved platform to deliver siRNA to the liver. We are optimizing this platform to deliver siRNA for the treatment of pain. siRNA against TRPV1 (siTRPV1) was chosen as a proof of concept. siTRPV1-LNPs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19245ab1338d898e67355d8ef5523f37
https://doi.org/10.1016/j.jpain.2021.03.048
https://doi.org/10.1016/j.jpain.2021.03.048