Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kandace M. Matzek"'
Autor:
Jacobus C. A. Van Meel, Kandace M. Matzek, Horst Lehmann, Michael Entzeroth, Volker Gladigau, Thomas Ebner, Jochen Schmid, Wolfgang Wienen, Ulrich Busch, Joachim Stangier, Joan Kempthorne-Rawson, Norbert Hauel
Publikováno v:
Cardiovascular Drug Reviews. 18:127-154
Telmisartan is a potent, long-lasting, nonpeptide antagonist of the angiotensin II type-1 (AT 1 ) receptor that is indicated for the treatment of essential hypertension. It selectively and insurmountably inhibits stimulation of the AT 1 receptor by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32555483ecd44fe24096f459659a4a87
https://doi.org/10.1111/j.1527-3466.2000.tb00039.x
https://doi.org/10.1111/j.1527-3466.2000.tb00039.x
Publikováno v:
The Journal of Clinical Pharmacology. 40:1380-1390
This randomized, double-blind, double-dummy, placebo-controlled, parallel-group study evaluated the dose-response relationship of telmisartan in 207 patients with mild to moderate hypertension (diastolic blood pressure [DBP] 100 to 114 mmHg). After a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a705d228edb4b1fbacae6e69a4ab7a8
https://doi.org/10.1177/009127000004001210
https://doi.org/10.1177/009127000004001210
Publikováno v:
European journal of clinical pharmacology. 38(4)
The pharmacokinetic properties of pirenzepine following administration of a single, 50 mg oral dose were evaluated in three groups of subjects: group I, end stage renal disease requiring maintenance haemodialysis (CLCR 0 to 10 ml.min-1); group II, mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceae0d5198f7c620deeb68f4d5f6b4a
https://pubmed.ncbi.nlm.nih.gov/2344866
https://pubmed.ncbi.nlm.nih.gov/2344866
Autor:
Kandace M. Matzek, Stephen T. Horhota, James J. Keirns, Peter R. Farina, Thomas R. MacGregor, Henry J. Esber
Publikováno v:
Journal of Pharmaceutical Sciences. 74:851-856
A pharmacodynamic approach was employed to examine the diuretic effect of chlorthalidone in beagle dogs and to identify parameters necessary for optimization of an oral dosage formulation of this drug. The extensive partitioning of chlorthalidone int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70faa9ff2e4f5738330ac094a972596
https://doi.org/10.1002/jps.2600740810
https://doi.org/10.1002/jps.2600740810
Publikováno v:
International Journal of Pharmaceutics. 28:85-91
The relative bioavailability of pirenzepine tablets (50 mg and two 25 mg) was assessed in 18 subjects in a single dose crossover study. The relative bioavailability of the tablet formulations, compared to a 50 mg oral reference solution given in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eee1100122ee3bd82b07b65b37eb0e3
https://doi.org/10.1016/0378-5173(86)90150-x
https://doi.org/10.1016/0378-5173(86)90150-x
Publikováno v:
International Journal of Pharmaceutics. 28:151-155
The effect of food or an aluminum and magnesium hydroxide antacid on the bioavailability of orally administered pirenzepine was evaluated in 20 subjects in a 4-way crossover study. The extent of oral bioavailability of a 50 mg pirenzepine tablet admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad7b35eddc01683c731bf5017239513
https://doi.org/10.1016/0378-5173(86)90240-1
https://doi.org/10.1016/0378-5173(86)90240-1
Autor:
Kandace M. Matzek, Abraham van den Ende, Rudolf G A van Wayjen, Thomas R. MacGregor, Rudolf G L van Tol, James J. Keirns
Publikováno v:
Clinical Pharmacology and Therapeutics. 38:278-284
We detail a series of pharmacokinetic investigations to determine the dose linearity, the effect of site of application, the duration of steady-state plasma concentrations, and the effect of chronic application when clonidine is administered transder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90536d1c01d14948e435c63b33eec30e
https://doi.org/10.1038/clpt.1985.171
https://doi.org/10.1038/clpt.1985.171
Publikováno v:
Journal of Clinical Pharmacology; Dec2000, Vol. 40 Issue 12, p1380-1390, 11p
Autor:
MacGregor, Thomas R, Matzek, Kandace M, Keirns, James J, van Wayjen, Rudolf G A, van den Ende, Abraham, van Tol, Rudolf G L
Publikováno v:
Clinical Pharmacology & Therapeutics; Sep1985, Vol. 38 Issue 3, p278-284, 7p