Výsledky vyhledávání

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability

Autor: Abbott, GW, Tai, KK, Neverisky, DL, Hansler, A, Hu, Z, Roepke, TK, Lerner, DJ, Chen, Q, Liu, L, Zupan, B, Toth, M, Haynes, R, Huang, X, Demirbas, D, Buccafusca, R, Gross, SS, Kanda, VA, Berry, GT

Publikováno v: Abbott, GW; Tai, KK; Neverisky, DL; Hansler, A; Hu, Z; Roepke, TK; et al.(2014). KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Science Signaling, 7(315). doi: 10.1126/scisignal.2005025. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7j82p53p

Na+-coupled solute transport is crucial for the uptake of nutrients and metabolic precursors, such as myo-inositol, an important osmolyte and precursor for various cell signaling molecules. We found that various solute transporters and potassium chan

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Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy

Autor: Heerdt, PM, Kant, R, Hu, Z, Kanda, VA, Christini, DJ, Malhotra, JK, Abbott, GW

Publikováno v: Heerdt, PM; Kant, R; Hu, Z; Kanda, VA; Christini, DJ; Malhotra, JK; et al.(2012). Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. Journal of Molecular and Cellular Cardiology, 53(3), 350-353. doi: 10.1016/j.yjmcc.2012.05.010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8ds9n0k9

Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K+ channel ancillary subunit gene. New-onset postoperative AF (POAF) generally occurs 48-7

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Protein kinase C downregulates I-Ks by stimulating KCNQ1-KCNE1 potassium channel endocytosis

Autor: Kanda, VA, Purtell, K, Abbott, GW

Publikováno v: Kanda, VA; Purtell, K; & Abbott, GW. (2011). Protein kinase C downregulates I-Ks by stimulating KCNQ1-KCNE1 potassium channel endocytosis. HEART RHYTHM, 8(10), 1641-1647. doi: 10.1016/j.hrthm.2011.04.034. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3b61q6v1

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KCNE1 and KCNE2 Provide a Checkpoint Governing Voltage-Gated Potassium Channel alpha-Subunit Composition

Autor: Kanda, VA, Lewis, A, Xu, X, Abbott, GW

Publikováno v: Kanda, VA; Lewis, A; Xu, X; & Abbott, GW. (2011). KCNE1 and KCNE2 Provide a Checkpoint Governing Voltage-Gated Potassium Channel alpha-Subunit Composition. BIOPHYSICAL JOURNAL, 101(6), 1364-1375. doi: 10.1016/j.bpj.2011.08.014. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2k3449kq

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Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo

Autor: Roepke, TK, King, EC, Purtell, K, Kanda, VA, Lerner, DJ, Abbott, GW

Publikováno v: Roepke, TK; King, EC; Purtell, K; Kanda, VA; Lerner, DJ; & Abbott, GW. (2011). Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB JOURNAL, 25(2), 727-736. doi: 10.1096/fj.10-173682. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/64v1k9wg

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Akademický článek

Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis.

Autor: Kanda VA, Purtell K, Abbott GW, Kanda, Vikram A, Purtell, Kerry, Abbott, Geoffrey W

Publikováno v: Heart Rhythm; Oct2011, Vol. 8 Issue 10, p1641-1647, 7p

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Akademický článek

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

Autor: Abbott GW; 1Bioelectricity Laboratory, Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA., Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT

Publikováno v: Science signaling [Sci Signal] 2014 Mar 04; Vol. 7 (315), pp. ra22. Date of Electronic Publication: 2014 Mar 04.

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Akademický článek

Mind the gap: disparity between research funding and costs of care for diabetic foot ulcers.

Autor: Armstrong DG; Department of Surgery, Division of Vascular and Endovascular Surgery, Southern Arizona Limb Salvage Alliance, University of Arizona College of Medicine, Tucson, Arizona, USA. armstrong@usa.net, Kanda VA, Lavery LA, Marston W, Mills JL Sr, Boulton AJ

Publikováno v: Diabetes care [Diabetes Care] 2013 Jul; Vol. 36 (7), pp. 1815-7.

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Akademický článek

Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy.

Autor: Heerdt PM; Dept. of Anesthesiology, Weill Cornell Medical College, 1300 York Ave., New York, NY 10021, USA. pmheerd@med.cornell.edu, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2012 Sep; Vol. 53 (3), pp. 350-3. Date of Electronic Publication: 2012 May 25.

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Akademický článek

KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task?

Autor: Kanda VA; Department of Biology, Manhattan College Riverdale, New York, NY, USA., Abbott GW

Publikováno v: Frontiers in physiology [Front Physiol] 2012 Jun 28; Vol. 3, pp. 231. Date of Electronic Publication: 2012 Jun 28 (Print Publication: 2012).

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