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Akademický článek

Methylenetetrahydrofolate reductase polymorphisms in dental caries-induced pulp inflammation and regeneration of dentine-pulp complex: Future perspectives

Autor: G. Uma Maheswari, B. Yamini, V.E. Dhandapani, Bader O. Almutairi, Selvaraj Arokiyaraj, Kanchana M. Karuppiah

Publikováno v: Saudi Dental Journal, Vol 35, Iss 8, Pp 1029-1038 (2023)

Dental caries (DC)-induced pulp infections usually undergo the common endodontic treatment, root canal therapy (RCT). Endodontically treated teeth are devitalized, become brittle and susceptible for re-infection which eventually results in dental los

Externí odkaz: https://doaj.org/article/198ef347f1f14f00840eed2504907f78

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Akademický článek

Trimetazidine with an adjuvant therapy to normalize the circulating visfatin concentration: Future perspective and mechanistic strategies

Autor: G. Uma Maheswari, B. Yamini, Ajay Guru, Manikandan Velayutham, V.E. Dhandapani, Kanchana M. Karuppiah, Nicholas Daniel Amalorpavanaden

Publikováno v: Journal of King Saud University: Science, Vol 35, Iss 10, Pp 102950- (2023)

Visfatin is an adipocytokine that exists in two forms, intracellular and extracellular. Circulating visfatin, which lacks the nicotinamide phosphoribosyltransferase (NAMPT) enzyme activity, functions as adipocytokine. Increased concentration of circu

Externí odkaz: https://doaj.org/article/ac8672c38f7f4ef19a301939d9a2dfc2

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Akademický článek

S-adenosylmethionine synthase-derived GR15 peptide suppresses proliferation of breast cancer cells by upregulating the caspase-mediated apoptotic pathway: In vitro and in silico analyses

Autor: Manikandan Velayutham, B. Haridevamuthu, Mohamed Farouk Elsadek, Humaira Rizwana, Annie Juliet, Kanchana M. Karuppiah, Jesu Arockiaraj

Publikováno v: Journal of King Saud University: Science, Vol 34, Iss 8, Pp 102354- (2022)

Introduction: GR15 peptide is a potential antioxidant peptide which reduces intercellular ROS levels in zebrafish larvae stressed with H2O2. Cancer is a condition which develops during oxidative stress due to various reasons. Antioxidant molecules pr

Externí odkaz: https://doaj.org/article/466893576fe94fdb95a78bef00eec661

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Akademický článek

GP13, an Arthrospira platensis cysteine desulfurase-derived peptide, suppresses oxidative stress and reduces apoptosis in human leucocytes and zebrafish (Danio rerio) embryo via attenuated caspase-3 expression

Autor: Purabi Sarkar, Ajay Guru, Stefi V. Raju, Abdullah Farasani, Atif Abdulwahab A. Oyouni, Othman R. Alzahrani, Hussam Awwadh E. Althagafi, Fahad Alharthi, Kanchana M. Karuppiah, Jesu Arockiaraj

Publikováno v: Journal of King Saud University: Science, Vol 33, Iss 8, Pp 101665- (2021)

Arthrospira platensis (Ap) has several advantageous adaptive mechanisms including its efficient response to elevated oxidative stress (OS). This study intends to identify the antioxidant effect, in vitro and in vivo, of a novel peptide (GP13), Ap-der

Externí odkaz: https://doaj.org/article/32af0bbb2404490f87270977fef80b82

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