Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kanan Pujara"'
Autor:
Howard M. Stern, Mark X. Sliwkowski, David P. Davis, Samuel A. Aparicio, Karen A. Gelmon, Gulisa Turashvili, Klaus P. Hoeflich, Somasekar Seshagiri, Ajay Pandita, Jeffrey Eastham-Anderson, Sara M. Chan, Jeremy Stinson, Kanan Pujara, Peter M. Haverty, Wei Zhou, Li Li, James Lee, Xander Munroe, Don Dowbenko, Thinh Q. Pham, Si Tuen Lee-Hoeflich
Figures PDF file - 501K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f23fbd364efc316093902fe50140995
https://doi.org/10.1158/2159-8290.22529087.v1
https://doi.org/10.1158/2159-8290.22529087.v1
Autor:
Robert Yauch, Dineli Wickramasinghe, Lukas Amler, Ralph Schwall, Linda Rangell, Christophe Severin, Ling Fu, Jeremy Stinson, Kanan Pujara, Thomas Holcomb, Nerissa Mendoza, Kaumudi Bhawe, Wenjing Zhu, Jiping Zha, Somasekar Seshagiri, Monica Kong-Beltran
Supplementary Figures S1-S5 from Somatic Mutations Lead to an Oncogenic Deletion of Met in Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801e3bc0d4cf95cf5288c807dd423732
https://doi.org/10.1158/0008-5472.22364528.v1
https://doi.org/10.1158/0008-5472.22364528.v1
Autor:
Robert Yauch, Dineli Wickramasinghe, Lukas Amler, Ralph Schwall, Linda Rangell, Christophe Severin, Ling Fu, Jeremy Stinson, Kanan Pujara, Thomas Holcomb, Nerissa Mendoza, Kaumudi Bhawe, Wenjing Zhu, Jiping Zha, Somasekar Seshagiri, Monica Kong-Beltran
Activating mutations in receptor tyrosine kinases play a critical role in oncogenesis. Despite evidence that Met kinase is deregulated in human cancer, the role of activating mutations in cancers other than renal papillary carcinoma has not been well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08540b2140f5ea3784c7cb22480f6146
https://doi.org/10.1158/0008-5472.c.6494228
https://doi.org/10.1158/0008-5472.c.6494228
Autor:
Wei Zhou, Samuel Aparicio, Xander Munroe, Somasekar Seshagiri, Klaus P. Hoeflich, Si Tuen Lee-Hoeflich, Jeremy Stinson, Don Dowbenko, James Lee, Jeffrey Eastham-Anderson, Li Li, David Davis, Kanan Pujara, Gulisa Turashvili, Sara M. Chan, Ajay Pandita, Mark X. Sliwkowski, Howard M. Stern, Peter M. Haverty, Karen A. Gelmon, Thinh Pham
Publikováno v:
Cancer Discovery. 1:326-337
The HER2 oncogene is overexpressed or amplified in 20% of breast cancers. HER2-positive cancer historically portends a poor prognosis, but the HER2-targeted therapy trastuzumab mitigates this otherwise ominous distinction. Nevertheless, some patients
Autor:
Wayne J. Fairbrother, Pawan Bir Kohli, Adam R. Johnson, Lisa D. Belmont, Ingrid E. Wertz, Mike Eby, Toru Okamoto, Mark L. Chiu, Cynthia Lam, Somasekar Seshagiri, Jinfeng Liu, Elizabeth Helgason, Jennie R. Lill, Kanan Pujara, Saritha Kusam, Heather Maecker, Vishva M. Dixit, Karen O'Rourke, Mary J. C. Ludlam, Peter K. Jackson, Wendy Sandoval, Erin C. Dueber, Daniel Anderson, Kevin G. Leong, James A. Ernst, David C.S. Huang, Joshua S. Kaminker
Publikováno v:
Nature. 471:110-114
Microtubules have pivotal roles in fundamental cellular processes and are targets of antitubulin chemotherapeutics. Microtubule-targeted agents such as Taxol and vincristine are prescribed widely for various malignancies, including ovarian and breast
Autor:
Krishna P. Bhat, Jonathan D. Buckley, Li Ding, Daniel J. Weisenberger, Richard K. Wilson, D. Neil Hayes, Christopher E. Pelloski, Kanan Pujara, Leslie Cope, Henrik Bengtsson, Kenneth Aldape, Pierre Neuvial, Kristin Diefes, James G. Herman, David Van Den Berg, Peter W. Laird, Fei Pan, Hui Shen, Erik P. Sulman, Heather Schmidt, Stephen B. Baylin, Charles M. Perou, Roel G.W. Verhaak, Heidi S. Phillips, Katherine A. Hoadley, Houtan Noushmehr, Benjamin P. Berman
Publikováno v:
Cancer Cell
Cancer Cell, Elsevier, 2010, 17 (5), pp.510-22
Cancer Cell, Elsevier, 2010, 17 (5), pp.510-22
International audience; We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large numbe
Autor:
Kanan Pujara, Ann Carlson, Marianne Berwick, Robert Hromas, José F. Morales, Jaya M. Satagopan, Orna Levran, Helmut Hanenberg, Sat Dev Batish, Detlev Schindler, Tom Landers, Kelly Milton, Leah Ben-Porat, Arleen D. Auerbach, Rashida Henry, Katherine Mah, Raffaella Diotti
Publikováno v:
Cancer Research. 67:9591-9596
Fanconi anemia (FA) is a rare autosomal recessive disease characterized by a greatly increased risk of cancer among those diagnosed with the syndrome. The question as to whether FA heterozygotes are at increased risk for cancer is of great importance
Autor:
Dineli Wickramasinghe, Ling Fu, Linda Rangell, Christophe Severin, Kanan Pujara, Robert L. Yauch, Somasekar Seshagiri, Kaumudi Bhawe, Lukas C. Amler, Jeremy Stinson, Nerissa Mendoza, Thomas Holcomb, Ralph H. Schwall, Monica Kong-Beltran, Jiping Zha, Wenjing Zhu
Publikováno v:
Cancer Research. 66:283-289
Activating mutations in receptor tyrosine kinases play a critical role in oncogenesis. Despite evidence that Met kinase is deregulated in human cancer, the role of activating mutations in cancers other than renal papillary carcinoma has not been well
Publikováno v:
Applied and Environmental Microbiology. 66:4105-4111
Electron microscope grids were submerged in Lake Washington, Seattle, Wash., in June 1996 as bait to which Caulobacter sp. swarmers would attach and on which they would then reproduce in situ. Enumeration of bands in the stalks of attached cells impl
Autor:
Albert Lai, Michael D. Prados, Cameron Escovedo, William F. Forrest, Timothy F. Cloughesy, Nils Ole Schmidt, Orestes E. Solis, Chauncey W. Bowers, Sankar Mohan, Katrin Lamszus, Samir Kharbanda, Zhaoshi Jiang, Kanan Pujara, Manfred Westphal, William H. Yong, Benjamin M. Ellingson, Linda M. Liau, Weidong Chen, Jose Carrillo, Zora Modrusan, C. David James, Whitney B. Pope, Paul S. Mischel, Franklin Peale, Heidi S. Phillips, Robert Soriano, Phioanh L. Nghiemphu, Kenneth Aldape, Somasekar Seshagiri, Anh Tran, Ajay Pandita
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(34)
Purpose Mutation in isocitrate dehydrogenase 1 (IDH1) at R132 (IDH1R132MUT) is frequent in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed as a marker for GBMs that arise by transformation from lower-grade gliomas, regardl