Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kaname Kimura"'
Autor:
Kazumasa Ohtake, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Mitsuo Kuratani, Akiko Hayashi, Yasuhisa Shiraishi, Kaname Kimura, Yoshimi Amano, Akifumi Kato, Kensaku Sakamoto
Publikováno v:
Bioconjugate chemistry. 28(8)
The site-specific chemical conjugation of proteins, following synthesis with an expanded genetic code, promises to advance antibody-based technologies, including antibody drug conjugation and the creation of bispecific Fab dimers. The incorporation o
Publikováno v:
The Proceedings of the Transportation and Logistics Conference. :137-140
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2561-2564
The size and position of a hydrophobic moiety on a benzolactam skeleton, which reproduces the active conformation and biological activity of teleocidins, play an important role in the appearance of the activity. We have designed and synthesized benzo
Autor:
Tatsushi Osawa, Masaharu Ishikawa, Toyoo Nakao, Hiroshi Iijima, Kaname Kimura, Junko Ito, Hiroyuki Kawai, Akihiro Ueno, Hiroshi Ohashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1945-1948
Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkyle
Autor:
Koichi Shudo, Paul E. Driedger, Hiroshi Fukasawa, Yasuyuki Endo, Akiko Itai, Kaname Kimura, Nobuo Tomioka, Masako Shimazu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:173-178
4-Hydroxymethyl-5a-methyl-1,3,4,5,5a beta,6,7,8,9,9a alpha-decahydro-2H-benz[d]azepin-2-ones (4-12), which were designed to mimic the biologically active conformation of teleocidins and benzolactams, were synthesized and evaluated for the ability to
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:1134-1137
The docking structure of bryostatin 1, a potent activator of protein kinase C (PKG), to the crystal structure of PKCδ cys2 domain was examined computationally. Prior to the docking study, possible conformers of the 20-membered ring of bryostatin 1 w
Autor:
Hiroshi Iijima, Hitomi Ueno, Yasuhiko Koezuka, Teruyuki Sakai, Akira Uchimura, Toshiyuki Shimizu, Kaname Kimura, Takenori Natori
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1905-1910
We examined effects of alpha-, beta-galactosylceramides (CalCers) and alpha-, beta-glucosylceramides (GlcCers) on the syngeneic mixed leukocyte reaction (MLR) using spleen cells (responder cells) and dendritic cells (DC, stimulator cells). The DC pre
Publikováno v:
ChemInform. 26
1-t-Butyldimethylsiloxy-8,11,11-trimethylbicyclo[5.3.1]undec-7-en-9-one (2) has been synthesized via intramolecular aldol condensation of the precursor 3 by combined use of lithium diisopropylamide (LDA) and CeCl3. The dicarbonyl compound 3 was prepa
Autor:
Koichi Shudo, Kaname Kimura, Akiko Itai, Masako Shimazu, Nobuo Tomioka, Yasuyuki Endo, Paul E. Driedger, Hiroshi Fukasawa
Publikováno v:
ChemInform. 30
4-Hydroxymethyl-5a-methyl-1,3,4,5,5a beta,6,7,8,9,9a alpha-decahydro-2H-benz[d]azepin-2-ones (4-12), which were designed to mimic the biologically active conformation of teleocidins and benzolactams, were synthesized and evaluated for the ability to
Autor:
Takashi Ohhara, Tooru Kimura, Nobuo Okazaki, Yoshio Hayashi, Shigeru Sugiyama, Hiroyoshi Matsumura, Yusuke Mori, Motoyasu Adachi, Ryota Kuroki, Y. Shoyama, Eijiro Honjo, Kazuo Kurihara, Kaname Kimura, Koushi Hidaka, Yoshiaki Kiso, Taro Tamada, Kazufumi Takano, Shigeki Arai, Hiroaki Adachi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(12)
HIV-1 protease is a dimeric aspartic protease that plays an essential role in viral replication. To further understand the catalytic mechanism and inhibitor recognition of HIV-1 protease, we need to determine the locations of key hydrogen atoms in th