Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kanamata, Reddy"'
Autor:
Seung Ho Shin, Do Young Lim, Kanamata Reddy, Margarita Malakhova, Fangfang Liu, Ting Wang, Mengqiu Song, Hanyong Chen, Ki Beom Bae, Joohyun Ryu, Kangdong Liu, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 22-31 (2017)
Colorectal cancer is associated with aberrant activation of the Wnt pathway. β-Catenin plays essential roles in the Wnt pathway by interacting with T-cell factor 4 (TCF4) to transcribe oncogenes. We synthesized a small molecule, referred to as HI-B1
Externí odkaz:
https://doaj.org/article/7ef1fa25b8f14e63908d778f34dab03d
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
ADA-07 synthesis, MS analysis and cytotoxicity assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150cfa086334ef830b5a4ab56a9ec7a2
https://doi.org/10.1158/1535-7163.22507695
https://doi.org/10.1158/1535-7163.22507695
Autor:
Zigang Dong, Ann M. Bode, Ronald A. Lubet, Andria Carper, Nu Ry Song, Jung-Hyun Shim, Jong-Eun Kim, Yong-Yeon Cho, Janos Nadas, Yan Li, Myoung Ok Kim, Kanamata Reddy, Dong Joon Kim
Supplementary Table 1 from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth In Vitro and In Vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241c041546900191a0ab3ef66e24fa25
https://doi.org/10.1158/1940-6207.22525788
https://doi.org/10.1158/1940-6207.22525788
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cea2c09d3c47954f5115d4bf80c4b45
https://doi.org/10.1158/1535-7163.c.6538761
https://doi.org/10.1158/1535-7163.c.6538761
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (early-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until the end of the study at week 28. B, external appearanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cc5e4050aa1b99876a50883685a238
https://doi.org/10.1158/1535-7163.22507683.v1
https://doi.org/10.1158/1535-7163.22507683.v1
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130e2a48963136f46b3b15a191d94404
https://doi.org/10.1158/1535-7163.22507677.v1
https://doi.org/10.1158/1535-7163.22507677.v1
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
The binding between ADA-07 and TOPK is illustrated by Maestro in the Schrödinger Suite. The binding model shows that the hydrogen atom (white color) of glycine binds with oxygen (red color) and nitrogen (blue color) of ADA-07 to form hydrogen bonds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d4bef5a184d9e850a5bf783cb8e5f2
https://doi.org/10.1158/1535-7163.22507686.v1
https://doi.org/10.1158/1535-7163.22507686.v1
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (late-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until week 28. B, external appearance of tumors. SKH-1 hairle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dc908a4ecf1416dcede65915dba308
https://doi.org/10.1158/1535-7163.22507680
https://doi.org/10.1158/1535-7163.22507680
Autor:
Zigang Dong, Scott M. Lippman, Hitoshi Ashida, Ann M. Bode, Moeez Ghani Rathore, Mee-Hyun Lee, Xiaoyu Chang, Weiya Ma, Ke Yao, Kanamata Reddy, Tatyana A. Zykova, Naomi Oi, Ting Wang, Hanyong Chen, Keke Wang, Ge Gao, Mangaladoss Fredimoses, Qiushi Wang, Tianshun Zhang
Malignant melanoma is an aggressive tumor of the skin and still lacks effective preventive and therapeutic treatments. In melanoma, both the BRAF/MEK/ERK and PI3-K/AKT signaling pathways are constitutively activated through multiple mechanisms, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e305aa01ea54c2574cbcd9598bb3b5
https://doi.org/10.1158/1940-6207.c.6547082
https://doi.org/10.1158/1940-6207.c.6547082
Autor:
Zigang Dong, Ying Xing, Ann M. Bode, Sally E. Dickinson, David Alberts, Clara Curiel-Lewandrowski, Joohyun Ryu, Weiya Ma, Tatyana Zykova, Eunmiri Roh, Keke Wang, Ke Yao, Hanyong Chen, Kanamata Reddy, Qiushi Wang, Tianshun Zhang, Ge Gao
The expression level of TOPK in normal skin cells (JB6 P+, NHDF) and skin cancer cells (A431 and SCC12). TOPK expression was assessed by Western blot using a specific antibody and β-actin was used as a loading control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b69b535b352164c3ce3d6f0cc34171
https://doi.org/10.1158/1535-7163.22507692
https://doi.org/10.1158/1535-7163.22507692