Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kanakaraju Manupati"'
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113780- (2024)
Summary: Autophagy is a conserved cellular process, and its dysfunction is implicated in cancer and other diseases. Here, we employ an in vivo CRISPR screen targeting genes implicated in the regulation of autophagy to identify the Nsfl1c gene encodin
Externí odkaz:
https://doaj.org/article/6dfc4b6f1cdc4d1d94d34f7184103731
Autor:
Debnath, Sudhan, Kanakaraju, Manupati, Islam, Minarul, Yeeravalli, Ragini, Sen, Debanjan, Das, Amitava *
Publikováno v:
In Computational Biology and Chemistry December 2019 83
Publikováno v:
Surgery. 171:235-244
Autophagy is a highly conserved process for maintaining cellular homeostasis. Upregulation of autophagy promotes metastasis by promoting the cancer stem cell state while also stimulating tumor cell migration and invasion. We hypothesized that autopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a042d12367a1beacdf2c67762e387817
https://doi.org/10.1016/j.surg.2021.08.024
https://doi.org/10.1016/j.surg.2021.08.024
Publikováno v:
Cancer Research. 83:5791-5791
Autophagy is a self-degradation process, it is essential for growth of heterogenous of breast cancer cells. Breast tumor heterogeneity majorly comprises bulk cancer cells & cancer stem cells (CSCs). Targeting either CSCs or cancer cells could lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d6d94fef70cc6eb214ce5a7157c1909
https://doi.org/10.1158/1538-7445.am2023-5791
https://doi.org/10.1158/1538-7445.am2023-5791
Autor:
Kanakaraju Manupati, Ritama Paul, Mingang Hao, Michael Haas, Zhaoqun Christine Bian, Tammy M. Holm, Jun-Lin Guan, Syn Kok Yeo
Publikováno v:
Cancers; Volume 14; Issue 2; Pages: 455
Cancers, Vol 14, Iss 455, p 455 (2022)
Cancers
Cancers, Vol 14, Iss 455, p 455 (2022)
Cancers
Simple Summary Breast cancer stem cells (BCSCs) are a small sub-population of cells within tumors with high metastatic potential. We identified biglycan (BGN) as a prospective molecular target in BCSCs that regulates the aggressive phenotypes of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b0bb06b273673f3f35fc62aa280072
Autor:
Amitava Das, Sandeep P. Bahekar, Kalyan Goswami, Sudhan Debnath, Priyanka Bhoj, Hemant S. Chandak, Kanakaraju Manupati
Publikováno v:
The FEBS Journal. 286:2167-2192
Glutathione S-transferase omega 1 (GSTO1) contributes to the inactivation of a wide range of drug compounds via conjugation to glutathione during phase reactions. Chemotherapy-induced GSTO1 expression in breast cancer cells leads to chemoresistance a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7510fef462c22f0fd8e7b87d0b55f9e5
https://doi.org/10.1111/febs.14813
https://doi.org/10.1111/febs.14813
Autor:
Kalyan Goswami, Ragini Yeeravalli, Amitava Das, Anupama Gupta, Digvijay Singh, Nitin Gangane, Komal Kaushik, Kanakaraju Manupati, Bhupendra Mehra
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1867(11)
Breast cancer stem cells (CSCs) are distinct CD44+-subpopulations that are involved in metastasis and chemoresistance. However, the underlying molecular mechanism of CD44 in breast CSCs-mediated tumorigenesis remains elusive. We observed high CD44 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1904006b4a2cdb66ce683d83061c457f
https://pubmed.ncbi.nlm.nih.gov/34311079
https://pubmed.ncbi.nlm.nih.gov/34311079
Autor:
Lakshmi D. Vijay, Amitava Das, Vadithe Lakshma Naik, Kanakaraju Manupati, Lavanya Reddy, Kavitha Donthiboina, Ragini Yeeravalli, Suja T. Dharmabalan
Publikováno v:
Anti-cancer agents in medicinal chemistry. 20(12)
Background: Discovery of small molecules that inhibit tubulin polymerization is an attractive strategy for the development of new and improved anti-proliferative agents. Objective: A series of novel 2-sulfonyl-1,1-diarylethenes were designed towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a693b9afbbffc2a7c4566ccf44b1cf7d
https://pubmed.ncbi.nlm.nih.gov/32324523
https://pubmed.ncbi.nlm.nih.gov/32324523
Publikováno v:
International Journal of Biological Macromolecules. 92:988-997
In the present study we synthesized lignin-tetra ethoxysilane (TEOS) nanocomposite and characterized it using UV-spectroscopy, Fourier Transform Infra-red spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Field Emission-Scanning Electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d481b9e490ca4dfa32357017f6e9a9ab
https://doi.org/10.1016/j.ijbiomac.2016.07.064
https://doi.org/10.1016/j.ijbiomac.2016.07.064
Autor:
Subba Rao V. Tulimilli, Ramasatyaveni Geesala, Amitava Das, Kanakaraju Manupati, Neha R. Dhoke, Sowmya Mekala
Publikováno v:
Canadian journal of physiology and pharmacology. 96(8)
Apoptotic hepatocytes release factors that activate hepatic stellate cells (HSCs), thereby inducing hepatic fibrosis. In the present study, in vivo and in vitro injury models were established using acetaminophen, ethanol, carbon tetrachloride, or thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3aa57f0df2e582adb3d66c44f63bfcd
https://pubmed.ncbi.nlm.nih.gov/29558627
https://pubmed.ncbi.nlm.nih.gov/29558627