Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kanagaraju Ponnusamy"'
Autor:
Aileen G. Rowan, Kanagaraju Ponnusamy, Hongwei Ren, Graham P. Taylor, Lucy B. M. Cook, Anastasios Karadimitris
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMost T cell receptor (TCR)Vβ chain-expressing T cell lymphomas (TCL) including those caused by Human T cell leukaemia virus type-1 (HTLV-1) have poor prognosis. We hypothesised that chimeric antigen receptor (CAR)-mediated targeting of t
Externí odkaz:
https://doaj.org/article/239fbb968c4d41e1af1c0426300c4b4b
Autor:
Jaime Alvarez-Benayas, Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Aristeidis Chaidos, Philippa C. May, Xiaolin Xiao, Marco Bua, Maria Atta, Irene A. G. Roberts, Holger W. Auner, Evdoxia Hatjiharissi, Maria Papaioannou, Valentina S. Caputo, Ian M. Sudbery, Anastasios Karadimitris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory la
Externí odkaz:
https://doaj.org/article/3fcdca45e3ee4529b529898c605a8394
Autor:
Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Multiple myeloma is a malignancy of plasma cells initiated and driven by primary and secondary genetic events. However, myeloma plasma cell survival and proliferation might be sustained by non-genetic drivers. Z-DNA-binding protein 1 (ZBP1; also know
Externí odkaz:
https://doaj.org/article/c3be2fdb2bb54d6ea4938d0fa843b835
Autor:
Valentina S. Caputo, Nikolaos Trasanidis, Xiaolin Xiao, Mark E. Robinson, Alexia Katsarou, Kanagaraju Ponnusamy, Rab K. Prinjha, Nicholas Smithers, Aristeidis Chaidos, Holger W. Auner, Anastasios Karadimitris
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101989- (2021)
Summary: Osteoclast (OC) development in response to nuclear factor kappa-Β ligand (RANKL) is critical for bone homeostasis in health and in disease. The early and direct chromatin regulatory changes imparted by the BET chromatin readers Brd2-4 and O
Externí odkaz:
https://doaj.org/article/5937c26f23c24a70a47ad818b646ebb2
Autor:
Simone Claudiani, Clinton C. Mason, Dragana Milojkovic, Andrea Bianchi, Cristina Pellegrini, Antinisca Di Marco, Carme R. Fiol, Mark Robinson, Kanagaraju Ponnusamy, Katya Mokretar, Avirup Chowdhury, Michael Albert, Alistair G. Reid, Michael W. Deininger, Kikkeri Naresh, Jane F. Apperley, Jamshid S. Khorashad
Publikováno v:
Cancers, Vol 13, Iss 19, p 4863 (2021)
As the first FDA-approved tyrosine kinase inhibitor for treatment of patients with myelofibrosis (MF), ruxolitinib improves clinical symptoms but does not lead to eradication of the disease or significant reduction of the mutated allele burden. The r
Externí odkaz:
https://doaj.org/article/06eecdbf71ec4f4380af60a91e20ec38
Autor:
Kanagaraju Ponnusamy, Linping Chen-Wichmann, Olga N. Kuvardina, Jörn Lausen, Reinhard Henschler, Christian Wichmann
Publikováno v:
Haematologica, Vol 99, Iss 12 (2014)
Externí odkaz:
https://doaj.org/article/2717707174fa4a15af3e6091405c5b7b
Autor:
Alexia Katsarou, Nikolaos Trasanidis, Kanagaraju Ponnusamy, Ioannis V Kostopoulos, Jaime Alvarez-Benayas, Foteini Papaleonidopoulou, Keren Keren, Pierangela MR Sabbattini, Niklas Feldhahn, Maria Papaioannou, Evdoxia Hatjiharissi, Ian M Sudbery, Aristeidis Chaidos, Valentina S Caputo, Anastasios Karadimitris
Publikováno v:
Blood Advances.
Deregulated expression of lineage-affiliated transcription factors is a major mechanism of oncogenesis. However, how deregulation of non-lineage affiliated TF impacts chromatin to initiate oncogenic transcriptional programmes is not well known. To ad
Autor:
Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Yao-An Shen, Ioannis V. Kostopoulos, Bien Bergonia, Keren Keren, Paudel Reema, Xiaolin Xiao, Richard M. Szydlo, Pierangela M. R. Sabbattini, Irene A. G. Roberts, Holger W. Auner, Kikkeri N. Naresh, Aristeidis Chaidos, Tian-Li Wang, Luca Magnani, Valentina S. Caputo, Anastasios Karadimitris
Publikováno v:
Blood. 139:1939-1953
Understanding the biological and clinical impact of copy number aberrations (CNAs) on the development of precision therapies in cancer remains an unmet challenge. Genetic amplification of chromosome 1q (chr1q-amp) is a major CNA conferring an adverse
Autor:
Aileen G Rowan, Kanagaraju Ponnusamy, Hongwei Ren, Graham Phillip Taylor, Lucy Cook, Anastasios Karadimitris
Publikováno v:
64th ASH Annual Meeting and Exposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0569b4a0d97d07fe2e8d650ed0eee39
http://hdl.handle.net/10044/1/104885
http://hdl.handle.net/10044/1/104885
Autor:
Kanagaraju Ponnusamy, Janani Kanagaraju, Yingxin Wang, Bryan Lye, Hongwei Ren, Sandhya Buchanan, Michael J. Baker, Mini Bharathan, Anastasios Karadimitris
Publikováno v:
Cancer Research. 83:913-913
Despite the approval of three autologous CAR-T cell products, B-cell malignancies still represent an unmet need as several of the relapsed/refractory patients are ineligible for autologous CART cell therapies. Invariant natural killer T (iNKT) cells