Výsledky vyhledávání - "Kanagaraj Sekar"

Akademický článek

Alternate conformations found in protein structures implies biological functions: A case study using cyclophilin A

Autor: Chandrasekaran Palaniappan, Santhosh Rajendran, Kanagaraj Sekar

Publikováno v: Current Research in Structural Biology, Vol 7, Iss , Pp 100145- (2024)

Protein dynamics linked to numerous biomolecular functions, such as ligand binding, allosteric regulation, and catalysis, must be better understood at the atomic level. Reactive atoms of key residues drive a repertoire of biomolecular functions by fl

Externí odkaz: https://doaj.org/article/69a79e72d6994447acd5dcf988a4aedc

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Akademický článek

Do we see what we should see? Describing non-covalent interactions in protein structures including precision

Autor: Manickam Gurusaran, Mani Shankar, Raju Nagarajan, John R. Helliwell, Kanagaraj Sekar

Publikováno v: IUCrJ, Vol 1, Iss 1, Pp 74-81 (2014)

The power of X-ray crystal structure analysis as a technique is to `see where the atoms are'. The results are extensively used by a wide variety of research communities. However, this `seeing where the atoms are' can give a false sense of security un

Externí odkaz: https://doaj.org/article/8030df5f06184d849d1642188fdbd583

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Akademický článek

Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.

Autor: Kirti Vaishnavi, Nishant Saxena, Navjot Shah, Rumani Singh, Kavyashree Manjunath, M Uthayakumar, Shankar P Kanaujia, Sunil C Kaul, Kanagaraj Sekar, Renu Wadhwa

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44419 (2012)

BACKGROUND AND PURPOSE:Withanolides are naturally occurring chemical compounds. They are secondary metabolites produced via oxidation of steroids and structurally consist of a steroid-backbone bound to a lactone or its derivatives. They are known to

Externí odkaz: https://doaj.org/article/e83ef72326714d8fa698f54b1c64b8f7

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Akademický článek

sRNAscanner: a computational tool for intergenic small RNA detection in bacterial genomes.

Autor: Jayavel Sridhar, Narmada Sambaturu, Radhakrishnan Sabarinathan, Hong-Yu Ou, Zixin Deng, Kanagaraj Sekar, Ziauddin Ahamed Rafi, Kumar Rajakumar

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e11970 (2010)

BACKGROUND: Bacterial non-coding small RNAs (sRNAs) have attracted considerable attention due to their ubiquitous nature and contribution to numerous cellular processes including survival, adaptation and pathogenesis. Existing computational approache

Externí odkaz: https://doaj.org/article/a7813254a7c24ebfaabe87b01bff6b83

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