Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kanae Gamo"'
Autor:
Midori Takeda, Hiroaki Ito, Keisuke Kitahata, Sota Sato, Akira Nishide, Kanae Gamo, Shunsuke Managi, Tohru Tezuka, Akihiko Yoshizawa, Minsoo Kim
Publikováno v:
Cells, Vol 13, Iss 18, p 1572 (2024)
Stromal cells play a critical role in the tumor microenvironment of breast cancer (BC), as they are recruited by tumor cells and regulate the metastatic spread. Though high expression of α-parvin, a member of the parvin family of actin-binding prote
Externí odkaz:
https://doaj.org/article/6056dc81110f454197f77ba450539916
Autor:
Aisha Yesbolatova, Yuichiro Saito, Naomi Kitamoto, Hatsune Makino-Itou, Rieko Ajima, Risako Nakano, Hirofumi Nakaoka, Kosuke Fukui, Kanae Gamo, Yusuke Tominari, Haruki Takeuchi, Yumiko Saga, Ken-ichiro Hayashi, Masato T. Kanemaki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Auxin-inducible degron systems can be leaky and require high doses of auxin. Here the authors establish AID2 which uses an OsTIR1 mutant and the ligand 5-Ph-IAA to overcome these problems and establish AID-mediated target depletion in mice.
Externí odkaz:
https://doaj.org/article/e96ad288aa7749f7bdb3f1e9cc207dea
Autor:
Risako Nakano, Aisha Yesbolatova, Yumiko Saga, Kosuke Fukui, Yuichiro Saito, Ken-ichiro Hayashi, Hirofumi Nakaoka, Kanae Gamo, Rieko Ajima, Naomi Kitamoto, Yusuke Tominari, Hatsune Makino-Itou, Masato T. Kanemaki, Haruki Takeuchi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Protein knockdown using the auxin-inducible degron (AID) technology is useful to study protein function in living cells because it induces rapid depletion, which makes it possible to observe an immediate phenotype. However, the current AID system has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09efdb250e08d6e722861b8a11682068
http://link.springer.com/article/10.1038/s41467-020-19532-z
http://link.springer.com/article/10.1038/s41467-020-19532-z
Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
Targeted protein degradation (TPD) is under intensive focus with respect to the next-generation drugs to target currently undruggable proteins. Bivalent type degraders, known as proteolysis-targeting chimeras (PROTACs), are an attractive but challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa2fa96e12d3f513bffc56dc1dc3059c
https://doi.org/10.1039/9781839160691-00167
https://doi.org/10.1039/9781839160691-00167
Autor:
Kanae Gamo, Zenyu Shiokawa, Takashi Ochi, Yosuke Sato, Yusuke Murakawa, Yuumi Okuzono, Masato Yabuki, Kyoko Sugimura, Hiroki Hayashi, Yutaka Nishimoto, Takahiro Miyazaki, Masaki Sagara, Masayuki Gotoh, Yoshimasa Ishimura, Yukihiko Ebisuno
Publikováno v:
Inflammatory Bowel Diseases
Background Anti–tumor necrosis factor alpha (anti-TNFα) therapy has become the mainstay of therapy for Crohn’s disease (CD). However, post-therapy, the recurrence rate is still high. The aim of this study was to dissect the molecular mechanism f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32bf0c0078cda40032818b86211267f
https://doi.org/10.1093/ibd/izy079
https://doi.org/10.1093/ibd/izy079
Autor:
Rina Kurisu, Akihiko Yoshimura, Maiko Takiguchi, Hideyuki Mototani, Yasushi Kondo, Tsutomu Takeuchi, Katsuya Suzuki, Yoshiaki Kassai, Yukihiko Ebisuno, Kanae Gamo, Masaru Takeshita, Yuumi Okuzono, Rimpei Morita, Keiko Koga
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesRheumatoid arthritis (RA) is an autoimmune disease accompanied by lymphocyte infiltration into joint synovium. While T cells are considered to be important for its pathogenesis, the features that are the most relevant to disease and how the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a7cc6a6ce38d161dc63d0f9521e674
https://pubmed.ncbi.nlm.nih.gov/31719039
https://pubmed.ncbi.nlm.nih.gov/31719039
Autor:
Minoru Waki, Takuji Oyama, Masao Ohashi, Hiroyuki Miyachi, Yuta Tanaka, Nobuyasu Matsuura, Kenji Matsuno, Hiroaki Tokiwa, Kanae Gamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4001-4005
We previously reported that a α-benzylphenylpropanoic acid-type hPPARγ-selective agonist with a piperidine ring as the hydrophobic tail part (3) exhibited sub-micromolar-order hPPARγ agonistic activity. In order to enhance the activity, we planned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960b81ca975b9260e56e488510f1b989
https://doi.org/10.1016/j.bmcl.2014.06.023
https://doi.org/10.1016/j.bmcl.2014.06.023
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 78:1052-1059
In previous reports, hesperidin, a flavonoid glucoside from citrus fruit, is hydrolyzed to hesperetin, an aglycone of hesperidin, and converted to the hesperetin glucuronides (H7-OG and H3′-OG) in vivo and depresses blood glucose levels. But there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7172925c781748a6d449a4e530dd8
https://doi.org/10.1080/09168451.2014.910097
https://doi.org/10.1080/09168451.2014.910097
Publikováno v:
Cancer Research. 79:2354-2354
IRAK-M has an important role in tightly controlling innate immune responsiveness to preserve homeostasis, mediating immune tolerance, and acts as a negative feedback regulator of TLR/IL-1R signaling pathway. Targeting IRAK-M, which expression is rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32af76713361a977f9a5bea0ed9b1965
https://doi.org/10.1158/1538-7445.am2019-2354
https://doi.org/10.1158/1538-7445.am2019-2354
Autor:
Nobuyasu Matsuura, Yukihiro Akao, Nobuyuki Takahashi, Teruo Kawada, Hiroyuki Miyachi, Kanae Gamo, Munekazu Iinuma, Hideki Tosa
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 77:2430-2435
We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9218689e7a416f13fa74bc0b34a01f6
https://doi.org/10.1271/bbb.130541
https://doi.org/10.1271/bbb.130541