Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kana Shimauchi"'
Autor:
Yann Grobs, Charifa Awada, Sarah-Eve Lemay, Charlotte Romanet, Alice Bourgeois, Victoria Toro, Valérie Nadeau, Kana Shimauchi, Mark Orcholski, Sandra Breuils-Bonnet, Eve Tremblay, Steeve Provencher, Roxane Paulin, Olivier Boucherat, Sébastien Bonnet
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2919 (2021)
Trifluoperazine (TFP), an antipsychotic drug approved by the Food and Drug Administration, has been show to exhibit anti-cancer effects. Pulmonary arterial hypertension (PAH) is a devastating disease characterized by a progressive obliteration of sma
Externí odkaz:
https://doaj.org/article/a773316ffc034a4791b9796d7d8f9482
Autor:
Tsukasa Shimauchi, Olivier Boucherat, Tetsuro Yokokawa, Yann Grobs, WenHui Wu, Mark Orcholski, Sandra Martineau, Junichi Omura, Eve Tremblay, Kana Shimauchi, Valérie Nadeau, Sandra Breuils-Bonnet, Roxane Paulin, François Potus, Steeve Provencher, Sébastien Bonnet
Publikováno v:
JACC: Basic to Translational Science. 7:384-403
The authors show that increased poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with pulmonary arterial hypertension and
Autor:
Tsukasa Shimauchi, Wenhui Wu, Yann Grobs, Junichi Omura, Eve Tremblay, Sandra Martineau, Tetsuro Yokokawa, Kana Shimauchi, Valerie Nadeau, Sandra Breuils Bonnet, Mark Orcholski, Roxane Paulin, Francois Potus, Olivier BOUCHERAT, Steeve Provencher, Sebastien Bonnet
Publikováno v:
Circulation. 144
Introduction: Right ventricular (RV) function is the poor prognosis factor in pulmonary arterial hypertension (PAH) patients. Inflammation, oxidative DNA damage, and glycolysis are key triggering pathways that induce cardiomyocytes (CM) dysfunction.
Autor:
Yann Grobs, Sarah-eve Lemay, Charlotte Romanet, Sandra Breuils Bonnet, Mark Orcholski, Alice Bourgeois, Melanie Sauvaget, Kana Shimauchi, Pierre Voisine, Roxane Paulin, Francois Potus, Steeve Provencher, Olivier BOUCHERAT, Sebastien Bonnet
Publikováno v:
Circulation. 144
Vascular remodeling diseases (VRD) like coronary artery diseases or in-stent restenosis are characterized by proliferative and apoptosis-resistant vascular smooth muscle cells (VSMCs). As in cancer, proliferative VSMCs have increased Warburg effect l