Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.

Autor: Natalia J Martinez, Ganesha Rai, Adam Yasgar, Wendy A Lea, Hongmao Sun, Yuhong Wang, Diane K Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, Mohiuddin, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J Maloney, Anton Simeonov

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166506 (2016)

[This corrects the article DOI: 10.1371/journal.pone.0161486.].

Externí odkaz: https://doaj.org/article/e1507d1cbf0448b0bcd91c7fd014f013

High-throughput and high content micronucleus assay in CHO-K1 cells

Autor: Menghang Xia, Kana Nishihara, Sampada A. Shahane

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781493963447

Visualization of micronuclei induction by chemicals and drugs enables measurement of possible compound genotoxicity. A loss of entire chromosome or a fragment of chromosome can lead to formation of micronuclei (MNi). The in vitro micronucleus assay c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759583868a78eb78b6f1d5d0b17dd447
https://europepmc.org/articles/PMC9922477/

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Autor: Kelli M. Wilson, Shunichi Takeda, Wendy A. Lea, Kazutoshi Mori, David J. Maloney, Gregory J. Riggins, Tetsuya Okada, Adam Yasgar, Maurizio Grimaldi, Anton Simeonov, Hongmao Sun, Ganesha Rai, Natalia J. Martinez, Mohiuddin Sagor, Diane K. Luci, Irina Earnshaw, Shyh Ming Yang, Kana Nishihara, Yuhong Wang, Ajit Jadhav, Menghang Xia

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161486 (2016)
PLoS ONE

The endoplasmic reticulum (ER) is involved in Ca2+ signaling and protein folding. ER Ca2+ depletion and accumulation of unfolded proteins activate the molecular chaperone GRP78 (glucose-regulated protein 78) which in turn triggers the ER stress respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114afaad8a52cd68318a9a10316f69dd
https://doi.org/10.1371/journal.pone.0161486

Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands

Autor: Takeo, Narita, Toshiki, Tsurimoto, Junpei, Yamamoto, Kana, Nishihara, Kaori, Ogawa, Eiji, Ohashi, Terry, Evans, Shigenori, Iwai, Shunichi, Takeda, Kouji, Hirota

Publikováno v: Genes to cells : devoted to molecularcellular mechanisms. 15(12)

DNA polymerase δ (Polδ) carries out DNA replication with extremely high accuracy. This great fidelity primarily depends on the efficient exclusion of incorrect base pairs from the active site of the polymerase domain. In addition, the 3'-5' exonucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e26fd6029443a705a50354356ba0085f
https://pubmed.ncbi.nlm.nih.gov/21070511

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

Autor: Kana Nishihara, Josef Jiricny, Satoshi Horimoto, Shunichi Takeda, Hitoshi Kurumizaka, Minoru Takata, Kazunori Yoshikiyo, Katja Kratz, Kouji Hirota

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences; Vol 107
Proceedings of the National Academy of Sciences

Fanconi anemia (FA) is a rare genetic disease characterized by congenital defects, bone marrow failure, chromosomal instability, and cancer susceptibility. One hallmark of cells from FA patients is hypersensitivity to interstrand cross-linking agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520c02fa873ccb2496d6c60fc5749c6e
https://doi.org/10.5167/uzh-44141