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Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

Autor: Toru Tanaka, Miyuki Nomura, Kenichiro Hara, Manabu Ueno, Masahiko Kurabayashi, Hiroki Matsui, Tatsuya Iso, Tatsuo Suga, Toshitaka Maeno, Kana Aoyagi-Ikeda

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 300(5)

Hypoxia-inducible factor-1α (HIF-1α), a transcription factor that functions as a master regulator of oxygen homeostasis, has been implicated in fibrinogenesis. Here, we explore the role of HIF-1α in transforming growth factor-β (TGF-β) signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e3c8981beb26ebde02a74efc015c90
https://pubmed.ncbi.nlm.nih.gov/21239537

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Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis

Autor: Yasuhiro Aoki, Toshitaka Maeno, Nozomi Aoki, Masashi Arai, Manabu Ueno, Kana Aoyagi, Junichi Nakagawa, Fumiaki Aoki, Tatsuo Suga, Masahiko Kurabayashi, Yoshichika Sando, Yuji Shimizu

Publikováno v: Respiration; international review of thoracic diseases. 77(3)

Background: Peroxisome proliferator-activated receptor-γ (PPARγ) ligands have been shown to possess potent anti-inflammatory actions. Idiopathic interstitial pneumonia is defined as a specific form of chronic fibrosing lung disease characterized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3445bf202f23dcc4b7739740b5e2bd81
https://pubmed.ncbi.nlm.nih.gov/18974632

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[A case of small cell lung carcinoma complicated by Lambert-Eaton myasthenic syndrome]

Autor: Zen, Isobe, Tatsuo, Suga, Toshimitsu, Katou, Kenichirou, Hara, Fumiaki, Aoki, Kana, Aoyagi, Manabu, Ueno, Toshitaka, Maeno, Masahiko, Kurabayashi

Publikováno v: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 46(3)

A 54-year old man was admitted with general fatigue, muscle weakness and dyspnea on effort. Medical examinations led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS). Marked improvement of SCLC and symp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ce72d6bc4ae5196ee9366156af195a6
https://pubmed.ncbi.nlm.nih.gov/18409571

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[Case of HLA-DR8 positive sarcoidosis following polymyositis and Sjögren's syndrome]

Autor: Zen, Isobe, Tatsuo, Suga, Shigeto, Hamaguchi, Shouzaburou, Yamaguchi, Kenichirou, Hara, Fumiaki, Aoki, Nozomi, Aoki, Kana, Aoyagi, Manabu, Ueno, Toshitaka, Maeno, Masahiko, Kurabayashi

Publikováno v: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 46(2)

A 69-year-old woman had been found to have idiopathic interstitial pneumonia (fibrotic NSIP) in 1997. Proximal muscle weakness appeared in April 2005. Chest CT revealed hilar and mediastinal lymphadenopathy. Polymyositis and Sjögren's syndrome were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d843e292bdfde3d0c455e666250418c
https://pubmed.ncbi.nlm.nih.gov/18318250

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[A case of miliary tuberculosis showing acute respiratory failure during pregnancy]

Autor: Zen, Isobe, Tatsuo, Suga, Shigeto, Hamaguchi, Shozaburo, Yamaguchi, Kenichirou, Hara, Fumiaki, Aoki, Nozomi, Aoki, Kana, Aoyagi, Manabu, Ueno, Toshitaka, Maeno, Masahiko, Kurabayashi

Publikováno v: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 45(11)

A 36-year-old Philippine woman had had fever and general fatigue from September, 2006 (11th week of pregnancy). She was admitted with high fever, general fatigue and dyspnea on October 16, 2006 (13th week of pregnancy). A chest radiograph on admissio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5da00f174975cc3aec2d959cdf6e94b
https://pubmed.ncbi.nlm.nih.gov/18051791

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[Case of acute interstitial pneumonia that responded to therapy but relapsed six months later]

Autor: Zen, Isobe, Tatsuo, Suga, Shigeto, Hamaguchi, Shouzaburou, Yamaguchi, Kenichirou, Hara, Fumiaki, Aoki, Nozomi, Aoki, Kana, Aoyagi, Manabu, Ueno, Toshitaka, Maeno, Kenji, Kasiwabara, Masahiko, Kurabayashi, Yoshinori, Kawabata

Publikováno v: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 45(10)

A 66-year-old man was admitted because of general fatigue. A chest computed tomography showed bilateral alveolar consolidation and ground glass opacities. Although we treated him with broad-spectrum antibiotics, his symptoms and chest image findings

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51bcfe07a204bf7f96a8be2587ae81bb
https://pubmed.ncbi.nlm.nih.gov/18018625

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[A case of Wegener's granulomatosis associated with the syndrome of inappropriate secretion of ADH]

Autor: Zen, Isobe, Tatsuo, Suga, Shigeto, Hamaguchi, Shouzaburou, Yamaguchi, Kenichirou, Hara, Fumiaki, Aoki, Nozomi, Aoki, Kana, Aoyagi, Manabu, Ueno, Toshitaka, Maeno, Masahiko, Kurabayashi

Publikováno v: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 45(9)

A 68 year-old woman was admitted with fever, productive cough and sore throat. A chest radiograph and a chest computed tomography showed multiple nodules in both lungs. Thoracoscopic lung biopsy was performed. The specimens showed vasculitis and geog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40eb878c6fe6d0b4cf9ac7c82ec9df50
https://pubmed.ncbi.nlm.nih.gov/17929469

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