Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Kana Harada"'
Autor:
Katsuya Sakimura, Takashi Kawai, Reiko Nashida, Yuji Ishida, Kana Harada, Takashi Suzuki, Chihiro Okuma, Gregory M. Cole
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slow progression, they fail to improve cognitive function. Deficits in glucose metabolism are reflected in FDG-PET and
Externí odkaz:
https://doaj.org/article/d0cd1b22ce1843a987fdf8ace4913d23
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 831-836 (2024)
When the International Society for Stem Cell Research revised its 2021 guidelines, it reversed its ban on the in vitro culture of human embryos beyond 14 days. However, despite widespread recognition of the importance of public debate on embryo resea
Externí odkaz:
https://doaj.org/article/38bf359314b24454a2efdfc57c80b902
Autor:
Izumi Hide, Hiroko Shiraki, Akihiro Masuda, Takuya Maeda, Mayuka Kumagai, Nao Kunishige, Yuhki Yanase, Kana Harada, Shigeru Tanaka, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 1, Pp 55-67 (2023)
Microglial removal of dying cells plays a beneficial role in maintaining homeostasis in the CNS, whereas under some pathological conditions, inflammatory microglia can cause excessive clearance, leading to neuronal death. However, the mechanisms unde
Externí odkaz:
https://doaj.org/article/2d9172ff569342c5b292d2925a9652a7
Publikováno v:
Regenerative Therapy, Vol 23, Iss , Pp 1-7 (2023)
Introduction: Restrictions on financial gains from the sale of human body parts is a leading policy issue surrounding the use of human tissues and cells. However, discrepancies exist between regulations and reality. In stem cell research, in which di
Externí odkaz:
https://doaj.org/article/45d942f301cd42d69a126acc31ab29bf
Autor:
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent prote
Externí odkaz:
https://doaj.org/article/6905b40dd76244c5a441fae6f3e08a09
Autor:
Yukari Kobayashi, Yuki Ito, Kosuke Taniguchi, Kana Harada, Michihiro Yamamura, Taisuke Sato, Ken Takahashi, Hiroshi Kawame, Kenichiro Hata, Osamu Samura, Aikou Okamoto
Publikováno v:
Human Genome Variation, Vol 9, Iss 1, Pp 1-3 (2022)
Abstract Achondrogenesis type II (ACG2) is a lethal skeletal disorder caused by pathogenic variants in COL2A1. We present a fetus with cystic hygroma and severe shortening of the limbs at 14 weeks of gestation. We performed postnatal genetic analysis
Externí odkaz:
https://doaj.org/article/4bc2455d0b994819af08283ac10492bd
Autor:
Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 307-314 (2022)
G protein-coupled receptor 3 (GPR3) constitutively activates Gαs proteins without any ligands and is predominantly expressed in neurons. Since the expression and physiological role of GPR3 in immune cells is still unknown, we examined the possible r
Externí odkaz:
https://doaj.org/article/404c9a5e05b5429a86af4e272363a08c
Autor:
Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Soma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 187-195 (2022)
Flurbiprofen, a nonsteroidal anti-inflammatory drug, reportedly exhibits chemical chaperone activity. Herein, we investigated the role of flurbiprofen in regulating serotonin transporter (SERT) function via membrane trafficking. We used COS-7 cells t
Externí odkaz:
https://doaj.org/article/9330ce51e2554433b6a7217e7813e997
Autor:
Shun Masuda, Shigeru Tanaka, Hiroko Shiraki, Yusuke Sotomaru, Kana Harada, Izumi Hide, Yoshiaki Kiuchi, Norio Sakai
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105811- (2022)
Glaucoma is an optic neuropathy and is currently one of the most common diseases that leads to irreversible blindness. The axonal degeneration that occurs before retinal ganglion neuronal loss is suggested to be involved in the pathogenesis of glauco
Externí odkaz:
https://doaj.org/article/cbcc8843261b4ff890e0fed40f1d323c
Autor:
Serika Motoike, Kei Taguchi, Kana Harada, Masaya Asano, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 4, Pp 297-307 (2021)
Herein, we investigated the functional association of the serotonin transporter (SERT) with syntaxin-3 (STX3). We first overexpressed SERT and STX3 in various cells and examined their interaction, localization, and functional association. Immunopreci
Externí odkaz:
https://doaj.org/article/a7c2315476ef45a8af9f1ada51c7284f