Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Kan Takagi"'
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Akademický článek
Solid gastric emptying mediated by the serotonin (5-HT)3receptor in mice is a simple marker to predict emesis.
Autor: Kentaro Ando1 (AUTHOR) akentaro@mail.ecc.u-tokyo.ac.jp, Kan Takagi2 (AUTHOR)
Publikováno v: Journal of Toxicological Sciences. 1/1/2011, Vol. 36 Issue 1, p23-29. 7p. 4 Graphs.
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Enhanced gastric retention of solid resin beads as a marker for emetic potential of agents in rats
Autor: Kentaro Ando, Hirokazu Tsubone, Kan Takagi
Publikováno v: The Journal of Toxicological Sciences. 37:549-553
Whereas nausea and emesis are burdensome side effects that lead to poor treatment compliance especially in chemotherapy, it is difficult to predict the emetic potential of agents in rats and mice because rodents do not vomit. We examined the effect o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926fb42bd27a366a2510a6026eda8e3a
https://doi.org/10.2131/jts.37.549
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4
Solid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis
Autor: Kentaro Ando, Kan Takagi
Publikováno v: The Journal of Toxicological Sciences. 36:23-29
Nausea and emesis are often observed as side effects with many medicines and may lead to poor treatment compliance. In the present study, we aimed to establish simple methods for predicting nausea and/or emesis in mice, which do not vomit, using drug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7795d836877733185982cb60f13491f
https://doi.org/10.2131/jts.36.23
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5
Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1 Agonists with Reduced Effect on Heart Rate
Autor: Kunitomo Adachi, Mahoko Asayama, Noriko Sato, Maiko Hamada, Kunio Sugahara, Mitsuharu Nakamura, Kaoru Marukawa, Ayumi Tomatsu, Masatoshi Kiuchi, Kyoko Shimano, Kan Takagi
Publikováno v: Journal of Medicinal Chemistry. 53:3154-3168
A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P(1)) receptor agonists with potent immunomodulatory activity accompanied by littl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf476da0a95a4d40f3dc7c1ce601a3f8
https://doi.org/10.1021/jm901776q
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6
Metal ion and vitamin adsorption profiles of phosphate binder ion-exchange resins
Autor: K. Masuda, C. Kiyohara, M. Wasaki, S. Itoh, M. Yamazaki, Hiroyoshi Inoue, Kan Takagi
Publikováno v: Clinical Nephrology. 73:30-35
AIMS To determine the metal ion and vitamin in vitro adsorption profile of sevelamer hydrochloride (sevelamer-HCl) and colestilan(INN)/colestimide(JAN), a novel ion-exchange resin being developed as a phosphate binder for end-stage renal disease (ESR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2688f03fa066ad3eeaa2d5d2c39304
https://doi.org/10.5414/cnp73030
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8
Spontaneous poorly differentiated carcinoma with cells positive for vimentin in a salivary gland of a young rat
Autor: Miyoko Okada, Jiro Sugimoto, Satomi Nishikawa, Shiro Takagi, Kan Takagi, Fumiko Sano
Publikováno v: Toxicologic pathology. 38(2)
Spontaneous salivary gland tumors in rats are rare. The authors report a poorly differentiated carcinoma of a submandibular gland in a ten-week-old rat that was positive for vimentin. Microscopically, the neoplastic cells showed a diffuse growth patt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0b56cfeb03a76bdf91122f00b2d8f1
https://pubmed.ncbi.nlm.nih.gov/20124499
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