Výsledky vyhledávání - "Kan Nakamura"

Akademický článek

A Case of Nonfunctioning Pituitary Carcinoma That Responded to Temozolomide Treatment

Autor: Haruko Morokuma, Takao Ando, Takuya Hayashida, Ichiro Horie, Naoko Inoshita, Fumi Murata, Ikuko Ueki, Kan Nakamura, Misa Imaizumi, Toshiro Usa, Atsushi Kawakami

Publikováno v: Case Reports in Endocrinology, Vol 2012 (2012)

Pituitary carcinoma is a rare malignancy and is difficult to manage. Pituitary carcinomas commonly produce either PRL or ACTH, but some do not produce pituitary hormones. The alkylating reagent temozolomide (TMZ) was recently shown to be effective as

Externí odkaz: https://doaj.org/article/8e766e05bb654bf38ac1de753335ec08

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Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice

Autor: Hitoshi Sasaki, Hironori Yamasaki, Shoichi Akazawa, T. Uchida, C Kaneko-Koike, Eiji Kawasaki, Masakazu Kobayashi, Genpei Kuriya, Kan Nakamura, Tsuyoshi Satoh, Norio Abiru, A. Kawakami, Hiroaki Ida, Yuji Nagayama

Publikováno v: Clinical and Experimental Immunology. 173:411-418

Summary Granzyme B (GzmB) and perforin are proteins, secreted mainly by natural killer cells and cytotoxic T lymphocytes that are largely responsible for the induction of apoptosis in target cells. Because type 1 diabetes results from the selective d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887566e646cda713607fe191f2181e01
https://doi.org/10.1111/cei.12134

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Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse

Autor: Yuji Nagayama, Norio Abiru, Yoichiro Iwakura, Kan Nakamura, A. Kawakami, Masakazu Kobayashi, T. Uchida, Ichiro Horie, Liping Yu, Hitoshi Sasaki, Hironori Yamasaki, Tsuyoshi Satoh, Genpei Kuriya, Shoichi Akazawa, Eiji Kawasaki

Publikováno v: Diabetologia. 56:1773-1780

T helper type (Th) 17 cells have been shown to play important roles in mouse models of several autoimmune diseases that have been classified as Th1 diseases. In the NOD mouse, the relevance of Th1 and Th17 is controversial, because single-cytokine-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063cea956845e229cb673e8244736c0e
https://doi.org/10.1007/s00125-013-2935-8

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A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI

Autor: Eriko Isomoto, Eiji Kawasaki, Atsushi Kawakami, Ichiro Horie, Satoru Akazawa, Masakazu Kobayashi, Kan Nakamura, Fumi Murata, Hideyuki Hayashi, Hironori Yamasaki, Norio Abiru, Hironaga Kuwahara, Takao Ando, Ikuko Ueki

Publikováno v: Endocrine Journal. 59:669-676

Glycogenic hepatopathy (GH) has been reported as a very rare and under recognized complication in long-standing poorly controlled type 1 diabetes (T1D) patients. GH is characterized by transient elevation of liver transaminase and hepatomegaly caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed00bf7b6d8b659cd27a24ec1d8338e
https://doi.org/10.1507/endocrj.ej12-0081

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Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes

Autor: Hironori Yamasaki, Nobuo Matsuura, Tsuyoshi Satoh, Genpei Kuriya, Hironaga Kuwahara, Kan Nakamura, Norio Abiru, Katsumi Eguchi, Masakazu Kobayashi, Yasuko Uchigata, Junnosuke Miura, Eiji Kawasaki

Publikováno v: Diabetes/Metabolism Research and Reviews. 27:895-898

The aim of this study was to determine the prevalence and role of autoantibodies to zinc transporter 8 (ZnT8A) in three forms (fulminant, acute-onset, and slow-onset) of Japanese patients with type 1 diabetes.One-hundred and ninety-six new-onset pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e7956496f8b2f70c35db88c0a6cad5
https://doi.org/10.1002/dmrr.1269

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Type 1 Diabetes and Interferon Therapy

Autor: Toshiaki Hanafusa, Tetsuro Kobayashi, Kan Nakamura, Taro Maruyama, Koji Nakanishi, Akira Shimada, Hideichi Makino, Takuya Awata, Yasuko Uchigata, Akihisa Imagawa, Hiroshi Ikegami, Eiji Kawasaki

Publikováno v: Diabetes Care

OBJECTIVE Interferon therapy can trigger induction of several autoimmune diseases, including type 1 diabetes. To assess the clinical, immunologic, and genetic characteristics of type 1 diabetes induced by interferon therapy, we conducted a nationwide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc72e509a303e0676d3b4117736cf50
https://doi.org/10.2337/dc10-2274

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CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse

Autor: Norio Abiru, Hongbo Zhou, Katsumi Eguchi, Masakazu Kobayashi, Masataka Mori, G S Eisenbarth, Yuji Nagayama, Liping Yu, Eiichi Araki, Kan Nakamura, Hideki Nakamura, Eiji Kawasaki, Genpei Kuriya, Seiichi Oyadomari, Hironori Yamasaki, Tsuyoshi Satoh

Publikováno v: Apoptosis : an international journal on programmed cell death. 16(4):438-448

C/EBP homologous protein (CHOP) has been proposed as a key transcription factor for endoplasmic reticulum (ER) stress-mediated β-cell death induced by inflammatory cytokines in vitro. However, the contribution of CHOP induction to the pathogenesis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2318829fabdff815a0de8221f1200e9
http://hdl.handle.net/10069/24877

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Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients

Autor: Nobuo Matsuura, Norio Abiru, Eiji Kawasaki, Junnosuke Miura, Hironori Yamasaki, Yasuko Uchigata, Genpei Kuriya, Hironaga Kuwahara, Katsumi Eguchi, Masakazu Kobayashi, Kan Nakamura, Tsuyoshi Satoh

Publikováno v: Clinical Immunology. 138:146-153

The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383b1d132f292ea9e08ec1c05c6bf33a
https://doi.org/10.1016/j.clim.2010.10.007

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Autoantibodies to Insulin, Insulinoma-Associated Antigen-2, and Zinc Transporter 8 Improve the Prediction of Early Insulin Requirement in Adult-Onset Autoimmune Diabetes

Autor: Eiji Kawasaki, Tsuyoshi Satoh, Katsumi Eguchi, Hironori Yamasaki, Genpei Kuriya, Hironaga Kuwahara, Masakazu Kobayashi, Norio Abiru, Kan Nakamura

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 95:707-713

Objective: The aim of this study was to indentify the predictive marker for early insulin requirement in adult-onset autoimmune diabetes in the Japanese populations.Design/Patients: We analyzed insulin autoantibodies (IAA), IA-2 autoantibodies (IA-2i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4d2d40900541caea40983107cc25e0
https://doi.org/10.1210/jc.2009-1733

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Trajectories of anti-islet autoantibodies before development of type 1 diabetes in interferon-treated hepatitis C patients. Case reports and a literature review

Autor: Kan Nakamura, Keiko Fukushima, Ozora Jo, Masakazu Kobayashi, Eiji Kawasaki, Katsumi Eguchi, Tatsuya Ide, Norio Abiru, Hironori Yamasaki, Genpei Kuriya, Hironaga Kuwahara, Tsuyoshi Satoh

Publikováno v: Endocrine Journal. 57:947-951

Interferon-alpha (IFN-α) is widely used in the treatment of viral hepatitis, however, it is known that IFN-α therapy may induce type 1 diabetes. We report here on two cases of chronic viral hepatitis C who developed autoimmune type 1 diabetes durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2578e1f007d4e48e14ea353faad39826
https://doi.org/10.1507/endocrj.k10e-207

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