Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kamran Kaveh"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008402 (2020)
Resources are rarely distributed uniformly within a population. Heterogeneity in the concentration of a drug, the quality of breeding sites, or wealth can all affect evolutionary dynamics. In this study, we represent a collection of properties affect
Externí odkaz:
https://doaj.org/article/190a6522d4654e348d53acd8014f814b
Autor:
Morgan Craig, Kamran Kaveh, Alec Woosley, Andrew S Brown, David Goldman, Elliot Eton, Ravindra M Mehta, Andrew Dhawan, Kazuya Arai, M Mamunur Rahman, Sidi Chen, Martin A Nowak, Aaron Goldman
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007278 (2019)
Understanding intrinsic and acquired resistance is crucial to overcoming cancer chemotherapy failure. While it is well-established that intratumor, subclonal genetic and phenotypic heterogeneity significantly contribute to resistance, it is not fully
Externí odkaz:
https://doaj.org/article/0d6fffb3382f4d45ba2967ac1a7ed714
Publikováno v:
Royal Society Open Science, Vol 6, Iss 1 (2019)
Many mathematical models of evolution assume that all individuals experience the same environment. Here, we study the Moran process in heterogeneous environments. The population is of finite size with two competing types, which are exposed to a fixed
Externí odkaz:
https://doaj.org/article/5de786ab006b4a8e9601965fc60ef2b9
Autor:
Kamran Kaveh, Yutaka Takahashi, Michael A Farrar, Guy Storme, Marcucci Guido, Jamie Piepenburg, Jackson Penning, Jasmine Foo, Kevin Z Leder, Susanta K Hui
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005482 (2017)
Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is characterized by a very poor prognosis and a high likelihood of acquired chemo-resistance. Although tyrosine kinase inhibitor (TKI) therapy has improved clinical outcome, mo
Externí odkaz:
https://doaj.org/article/1cb6e7965526413d84fc296a2d2a4f48
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187000 (2017)
The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous populatio
Externí odkaz:
https://doaj.org/article/25e365b210864dc4ab9b2b1f5b026ae0
Publikováno v:
Royal Society Open Science, Vol 2, Iss 4 (2015)
Evolutionary models on graphs, as an extension of the Moran process, have two major implementations: birth–death (BD) models (or the invasion process) and death–birth (DB) models (or voter models). The isothermal theorem states that the fixation
Externí odkaz:
https://doaj.org/article/fc56eebc79cd4c06878e5e0c4a98f6f9
Publikováno v:
Seminars in Cancer Biology. 92:61-73
Publikováno v:
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. 479
Populations evolve in spatially heterogeneous environments. While a certain trait might bring a fitness advantage in some patch of the environment, a different trait might be advantageous in another patch. Here, we study the Moran birth–death proce
Publikováno v:
Journal of Theoretical Biology. 564:111436
Autor:
Larry F. Lemanski, Andrei Kochegarov, Kamran Kaveh, Michael Neal, Ashley Arms, Yelica L Rodriguez, Lan Hong, M. Javed Equbal, Pipasha Biswas, Priya Biswas, Matthew Gonzalez, Jewel Ross-Ferguson, Justin Rusk, Lani Lyman- Henley, Tearah McRae-Kee, Curtis Ivory, Zhengshan Zhao
Publikováno v:
Stem Cell and Regenerative Medicine. 5
The present study explores an RNA we have discovered in human heart that induces differentiation of mouse embryonic stem cells and human induced pluripotent stem cells into cardiomyocytes in vitro. We have designated this RNA as Cardiac Inducing RNA