Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kamran Gharehbaghi"'
Publikováno v:
Frauenheilkunde up2date. 11:123-135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd95d2c64243f28ebd5fab69aaed00d2
https://doi.org/10.1055/s-0043-103009
https://doi.org/10.1055/s-0043-103009
Publikováno v:
Current Medicinal Chemistry. 9:743-748
Benzamide is a well known inhibitor of poly(ADP-ribose)polymerase, an enzyme involved in DNA repair. However, benzamide exhibited neuotoxicity in animals and hence, in the hope of overcoming this problem, benzamide riboside (BR) was synthesized. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24d7dabfab8b7daf8fbc2398e9e1486
https://doi.org/10.2174/0929867024606902
https://doi.org/10.2174/0929867024606902
Autor:
Hiremagalur N. Jayaram, Thomas Szekeres, Joel A. Yalowitz, Yves G. Pommier, Kamran Gharehbaghi, Monika Fritzer-Szekeres
Publikováno v:
Life Sciences. 68:1-11
Cyclopentenylcytosine (CPEC) is cytotoxic to HT-29 cells in vitro and in vivo. Treatment with CPEC resulted in sensitizing HT-29 cells to cisplatin (CDDP), as evidenced by synergistic cytotoxicity. CPEC exhibits potent cytotoxicity to HT-29 cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3cd92ec967d3c8986afd00f0559823
https://doi.org/10.1016/s0024-3205(00)00914-0
https://doi.org/10.1016/s0024-3205(00)00914-0
Autor:
Hiremagalur N. Jayaram, Kenneth D. Paull, Ajay Sreenath, Kamran Gharehbaghi, Karsten Krohn, Zhang Hao, David A. Cooney, Thomas Szekeres
Publikováno v:
Biochemical Pharmacology. 48:1413-1419
The biochemical and cytotoxic activities of the IMP dehydrogenase (IMPDH) inhibitors benzamide riboside, tiazofurin, and selenazofurin were compared. These three C-nucleosides exert their cytotoxicity by forming an analogue of NAD, wherein nicotinami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3faf55ed80182bff2fc32305ecc3eb5
https://doi.org/10.1016/0006-2952(94)90565-7
https://doi.org/10.1016/0006-2952(94)90565-7
Autor:
Howard L. Elford, Hiremagalur N. Jayaram, Bart Van't Riet, Thomas Szekeres, Monika Fritzer, Arun Srivastava, Michael J. Woody, Kamran Gharehbaghi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 34:63-66
Trimidox (3,4,5-trihydroxybenzamidoxime), a newly synthesized analog of didox (N,3,4-trihydroxybenzamide) reduced the activity of ribonucleotide reductase (EC 1.17.4.1) in extracts of L1210 cells by 50% (50% growth-inhibitory concentration, IC50) at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ba206b6cab7a9459d58b6c32ae56e0
https://doi.org/10.1007/bf00686113
https://doi.org/10.1007/bf00686113
Autor:
Peter Chiba, Kamran Gharehbaghi, Gabi Ressmann, Stefan M. Szalay, Christian Lhotka, Konrad Pillwein, Thomas Szekeres, Katharina Schuchter
Publikováno v:
Biochemical Pharmacology. 46:1903-1907
The activity of IMP dehydrogenase (EC 1.2.1.14), the key enzyme of de novo guanylate biosynthesis, was shown to be increased in tumor cells. Tiazofurin (TR), a potent and specific inhibitor of this enzyme, proved to be effective in the treatment of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec217efb3e882be225e607e29efc4fa
https://doi.org/10.1016/0006-2952(93)90630-f
https://doi.org/10.1016/0006-2952(93)90630-f
Autor:
Burgess Gs, Boswell Hs, Keisuke Miyazawa, Kamran Gharehbaghi, D. S. Leibowitz, R. A. Mandanas, T Tauchi, Hiremagalur N. Jayaram
Publikováno v:
Blood. 82:1838-1847
The p21 RAS product has been implicated as part of the downstream signaling of certain nonreceptor tyrosine kinase oncogenes and several growth factor receptor-ligand interactions. We have reported that the chronic myelogenous leukemia oncogene p210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124563f92e8c66ed7a8b78875cf09331
https://doi.org/10.1182/blood.v82.6.1838.bloodjournal8261838
https://doi.org/10.1182/blood.v82.6.1838.bloodjournal8261838
Autor:
Stefan M. Szalay, Katharina Schuchter, Thomas Szekeres, Hiremagalur N. Jayaram, Gabi Ressmann, Andreas Knoflach, Konrad Pillwein, Kamran Gharehbaghi, Peter Chiba, Benedikt Cermak
Publikováno v:
International Journal of Cancer. 55:92-95
The IMP dehydrogenase inhibitor, tiazofurin (TR)-2-β-D-ribofuranosylthiazole-4-carboxamide, which exhibited oncolytic activity in patients with chronic myelogenous leukaemia (CML) in blast crisis was found to inhibit the growth of human neuroblastom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b24eb1924440fc528444ff6b6435164
https://doi.org/10.1002/ijc.2910550117
https://doi.org/10.1002/ijc.2910550117
Autor:
Monika Fritzer, Peter Chiba, Hans Goldenberg, Konrad Pillwein, Thomas Szekeres, Kamran Gharehbaghi
Publikováno v:
Scopus-Elsevier
Cytokines, such as granulocyte macrophage colony stimulating factor (GM-CSF) or interleukin-3 (IL-3) recruit quiescent cells into the cell cycle and sensitize these cells towards cell cycle specific chemotherapeutic agents. We examined the in vitro e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde038081437ecad8c4e03ba536083ee
https://doi.org/10.1111/j.1365-2141.1993.tb03120.x
https://doi.org/10.1111/j.1365-2141.1993.tb03120.x
Autor:
Andreas Kubin, Werner Grunberger, Franz Wierrani, Rudolf Jindra, G. Alth, Michael Henry, Wolfgang Grin, Josef Soltz-Szotz, Kamran Gharehbaghi
Publikováno v:
Cancer detection and prevention. 23(4)
The aim of this study was to treat patients for ectocervical dysplasia [cervical intraepithelial neoplasia (CIN) grades 1 and 2] and associated human papilloma virus (HPV) infections with photodynamic therapy (PDT). In 20 patients, 5-aminolevulinic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473b8809ecf248e1d5604021e8940fa7
https://pubmed.ncbi.nlm.nih.gov/10403907
https://pubmed.ncbi.nlm.nih.gov/10403907