Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Kamran, Ghoreschi"'
Autor:
Lukas Heinlein, Roman C. Maron, Achim Hekler, Sarah Haggenmüller, Christoph Wies, Jochen S. Utikal, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Lars E. French, Lucie Heinzerling, Justin G. Schlager, Kamran Ghoreschi, Max Schlaak, Franz J. Hilke, Gabriela Poch, Sören Korsing, Carola Berking, Markus V. Heppt, Michael Erdmann, Sebastian Haferkamp, Konstantin Drexler, Dirk Schadendorf, Wiebke Sondermann, Matthias Goebeler, Bastian Schilling, Eva Krieghoff-Henning, Titus J. Brinker
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Early detection of melanoma, a potentially lethal type of skin cancer with high prevalence worldwide, improves patient prognosis. In retrospective studies, artificial intelligence (AI) has proven to be helpful for enhancing melano
Externí odkaz:
https://doaj.org/article/b94e12d429514a5caf386ed1f4f44417
Autor:
Tirtha Chanda, Katja Hauser, Sarah Hobelsberger, Tabea-Clara Bucher, Carina Nogueira Garcia, Christoph Wies, Harald Kittler, Philipp Tschandl, Cristian Navarrete-Dechent, Sebastian Podlipnik, Emmanouil Chousakos, Iva Crnaric, Jovana Majstorovic, Linda Alhajwan, Tanya Foreman, Sandra Peternel, Sergei Sarap, İrem Özdemir, Raymond L. Barnhill, Mar Llamas-Velasco, Gabriela Poch, Sören Korsing, Wiebke Sondermann, Frank Friedrich Gellrich, Markus V. Heppt, Michael Erdmann, Sebastian Haferkamp, Konstantin Drexler, Matthias Goebeler, Bastian Schilling, Jochen S. Utikal, Kamran Ghoreschi, Stefan Fröhling, Eva Krieghoff-Henning, Reader Study Consortium, Titus J. Brinker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Artificial intelligence (AI) systems have been shown to help dermatologists diagnose melanoma more accurately, however they lack transparency, hindering user acceptance. Explainable AI (XAI) methods can help to increase transparency, yet oft
Externí odkaz:
https://doaj.org/article/a7c398cf0b3b4b35ad5fc17b7f22b907
Autor:
Philipp Knopf, Dimitri Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M. Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D. Pagel, Marieke F. Fransen, Martin Röcken, André F. Martins, Bernd J. Pichler, Kamran Ghoreschi, Manfred Kneilling
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L
Externí odkaz:
https://doaj.org/article/b3fa661fa2c8409a83b991ccda94efe7
Autor:
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermair, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament anch
Externí odkaz:
https://doaj.org/article/a933bd3a4505443a83704c045d6c6602
Autor:
Anna Balato, Emanuele Scala, Kilian Eyerich, Nicolo Costantino Brembilla, Andrea Chiricozzi, Robert Sabat, Kamran Ghoreschi
Publikováno v:
Dermatology Practical & Conceptual, Vol 13, Iss 1 (2023)
Modern treatments continue to be developed, based on identifying targets within the innate and adaptive immune pathways associated with psoriasis. Whilst there is a sound biologic rationale for increased risk of infection following treatment with imm
Externí odkaz:
https://doaj.org/article/21b4e20be6e4414dbd814db6b448a5af
Autor:
Jean-Baptiste Telliez, Massimo Gadina, Kamran Ghoreschi, Olli Silvennoinen, Francesca Romana Spinelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2d315910124d4ad8a4db33f8e630f4f6
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundHidradenitis suppurativa (HS) is a common chronic inflammatory skin disease, which affects both sexes.ObjectivesIdentification of sex-specific risk factors, comorbidity, clinical manifestations, and treatments in HS patients.MethodsA non-in
Externí odkaz:
https://doaj.org/article/8bc58f6f62ea4be3bbac02034f875e1b
Autor:
Alexandra Polakova, Leonie Kauter, Adina Ismagambetova, Dario Didona, Farzan Solimani, Kamran Ghoreschi, Michael Hertl, Christian Möbs, Christoph Hudemann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Analysis of T lymphocyte proliferation and activation after antigenic or mitogenic stimulation is a vital parameter used in the diagnosis of various immuno-deficiencies and during the monitoring of treatment responses. Most applied techniques are bas
Externí odkaz:
https://doaj.org/article/d9709003ca344348a6e3996d8dd71d55
Autor:
Katrin Witte, Sylke Schneider-Burrus, Gabriela Salinas, Rotraut Mössner, Kamran Ghoreschi, Kerstin Wolk, Robert Sabat
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8854 (2023)
Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful lesions on intertriginous body areas such as the axillary, inguinal, and perianal sites. Given the limited treatment options for HS, expanding our knowledge of its
Externí odkaz:
https://doaj.org/article/96aaf5c20e124ebfb08a4ddb32cae1bf
Autor:
Thomas Schmitt, Julia Pircher, Letyfee Steinert, Katharina Meier, Kamran Ghoreschi, Franziska Vielmuth, Daniela Kugelmann, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers ha
Externí odkaz:
https://doaj.org/article/b406899fe8ce4df4930d2158cfec3c22