Výsledky vyhledávání - "Kamonchanok Sansuk"

Oligomerization of Recombinant and Endogenously Expressed Human Histamine H4Receptors

Autor: Richard M. van Rijn, Remko A. Bakker, Fiona C. Shenton, Paul L. Chazot, Rob Leurs, Kamonchanok Sansuk

Publikováno v: van Rijn, R, Chazot, P L, Shenton, F C, Sansuk, K, Bakker, R A & Leurs, R 2006, ' Oligomerization of recombinant and endogenously expressed human histamine H(4) receptors ', Molecular Pharmacology, vol. 70, no. 2, pp. 604-15 . https://doi.org/10.1124/mol.105.020818
Molecular Pharmacology, 70(2), 604-15. American Society for Pharmacology and Experimental Therapeutics

In this study, we report the homo- and hetero-oligomerization of the human histamine H(4)R by both biochemical (Western blot and immobilized metal affinity chromatography) and biophysical [bioluminescence resonance energy transfer and time-resolved f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782a45de9bcd5b615f8d78f501be475b
https://doi.org/10.1124/mol.105.020818

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A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation

Autor: Saskia Nijmeijer, Rob Leurs, Ivan R. Torrecillas, Leonardo Pardo, Remko A. Bakker, Kamonchanok Sansuk, Xavier Deupi, Aldo Jongejan

Publikováno v: Molecular pharmacology. 79(2)

Rearrangement of transmembrane domains (TMs) 3 and 5 after agonist binding is necessary for stabilization of the active state of class A G protein-coupled receptors (GPCRs). Using site-directed mutagenesis and functional assays, we provide the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91acad62a8f635c968a849358062db9
https://pubmed.ncbi.nlm.nih.gov/21081645

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Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach

Autor: Obbe P. Zuiderveld, Eric E. J. Haaksma, Kamonchanok Sansuk, Adami M, Joachim Broeker, Gabriella Coruzzi, Rob Leurs, Rogier A. Smits, Elena Guaita, Iwan J. P. de Esch

Publikováno v: Journal of medicinal chemistry. 51(24)

From a series of small fragments that was designed to probe the histamine H(4) receptor (H(4)R), we previously described quinoxaline-containing fragments that were grown into high affinity H(4)R ligands in a process that was guided by pharmacophore m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c6e89c5c9a0eb9d819e19f66e22569
https://pubmed.ncbi.nlm.nih.gov/19053770

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Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor

Autor: Kamonchanok Sansuk, Paul L. Chazot, Remko A. Bakker, Richard M. van Rijn, Rob Leurs, Yongjun Qin, Fiona C. Shenton, Michel Dy, Obbe P. Zuiderveld, André van Marle, Cornelis P. Tensen, Ellen Langemeijer, Martine J. Smit, Herman D. Lim

Publikováno v: van Rijn, R, van Marle, A, Chazot, P L, Langemeijer, E V, Qin, Y, Shenton, F C, Lim, H D, Zuiderveld, O P, Sansuk, K, Dy, M, Smit, M J, Tensen, C P, Bakker, R A & Leurs, R 2008, ' Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor ', Biochemical Journal, vol. 414, no. 1, pp. 121-31 . https://doi.org/10.1042/BJ20071583
Biochemical Journal
Biochemical Journal, Portland Press, 2008, 414, pp.121-131
Biochem. J.
Biochem. J., 2008, 414, pp.121-131
Biochemical Journal, 414(1), 121-31. Portland Press Ltd.

The H(4)R (histamine H(4) receptor) is the latest identified member of the histamine receptor subfamily of GPCRs (G-protein-coupled receptors) with potential functional implications in inflammatory diseases and cancer. The H(4)R is primarily expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21f4855d0bac77b7f8b754d2d09e04a
https://hal.archives-ouvertes.fr/hal-00323634

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Vitamin K1 accumulation in tobacco plants overexpressing bacterial genes involved in the biosynthesis of salicylic acid

Autor: Kamonchanok Sansuk, Robert Verpoorte, John F. Bol, Huub J. M. Linthorst, Marianne C. Verberne

Publikováno v: Journal of biotechnology. 128(1)

Phylloquinone (Vitamin K(1)) is an essential component of the photosynthetic electron transfer. As isochorismate is required for the biosynthesis of Vitamin K(1), isochorismate synthase (ICS) activity is expected to be present in all green plants. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fb8896c2f9cc6dc631e84c9399c668
https://pubmed.ncbi.nlm.nih.gov/17084477

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