Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kamna Katiyar"'
Autor:
Jonathan Rios-Doria, Margaret Favata, Kerri Lasky, Patricia Feldman, Yvonne Lo, Gengjie Yang, Christina Stevens, Xiaoming Wen, Sarita Sehra, Kamna Katiyar, Ke Liu, Richard Wynn, Jennifer J. Harris, Min Ye, Susan Spitz, Xiaozhao Wang, Chunhong He, Yun-Long Li, Wenqing Yao, Maryanne Covington, Peggy Scherle, Holly Koblish
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play important roles in tumor growth, survival, cell adhesion, as well as innate immunity, phagocytosis, and immune-suppressive activity. Therefore, targeting both AX
Externí odkaz:
https://doaj.org/article/8d1cee9d42734905aea555ac4d51cd11
Autor:
Qian Wang, Sybil O'Connor, Alan Roberts, Brian W. Metcalf, Leslie Hall, Maxim Soloviev, Michael Hansbury, Greg Hollis, Xin He, Matthew C. Stubbs, Niu Shin, Wenqing Yao, Kamna Katiyar, Phillip C.C. Liu, Kathy Wang, Sharon Diamond, Brent Douty, Gengjie Yang, Dana Shuey, Maryanne B. Covington, Paul Collier, Mingming Gao, Patricia Feldman, Peggy Scherle, Timothy Burn, Andrew P. Combs, Yun-Long Li, Lynn Leffet, Robert C. Newton, Paul Waeltz, Holly Koblish, Jin Lu, Swamy Yeleswaram, Yanlong Li, Reid Huber, Robert Collins, Eddy W. Yue
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:211-222
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)δ inhibitors in B-cell malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, and/or discontinuation of therapy. In addition, potential molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450ddea425cecfdf40bf1184c7e8c723
https://doi.org/10.1124/jpet.120.265538
https://doi.org/10.1124/jpet.120.265538
Autor:
Colin, Zhang, Meizhong, Xu, Chunhong, He, Jincong, Zhuo, David M, Burns, Ding-Quan, Qian, Qiyan, Lin, Yun-Long, Li, Lihua, Chen, Eric, Shi, Costas, Agrios, Linkai, Weng, Vaqar, Sharief, Ravi, Jalluri, Yanlong, Li, Peggy, Scherle, Sharon, Diamond, Deborah, Hunter, Maryanne, Covington, Cindy, Marando, Richard, Wynn, Kamna, Katiyar, Nancy, Contel, Kris, Vaddi, Swamy, Yeleswaram, Gregory, Hollis, Reid, Huber, Steve, Friedman, Brian, Metcalf, Wenqing, Yao
Publikováno v:
SSRN Electronic Journal.
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692552a04b6f880ed62ecd30b202590
https://doi.org/10.2139/ssrn.4056120
https://doi.org/10.2139/ssrn.4056120
Autor:
Richard Wynn, Kamna Katiyar, Jonathan Rios-Doria, Ke Liu, Patricia Feldman, Maryanne B. Covington, Susan M. Spitz, Kerri Lasky, Jennifer J. Harris, Chunhong He, Christina Stevens, Min Ye, Sarita Sehra, Xiaozhao Wang, Holly Koblish, Yvonne Lo, Gengjie Yang, Margaret F. Favata, Peggy Scherle, Wenqing Yao, Yun-Long Li, Xiaoming Wen
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology
TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play important roles in tumor growth, survival, cell adhesion, as well as innate immunity, phagocytosis, and immune-suppressive activity. Therefore, targeting both AX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb7a2f2b80fd7c3166a51188dd2f4cf
https://www.frontiersin.org/articles/10.3389/fonc.2020.598477/full
https://www.frontiersin.org/articles/10.3389/fonc.2020.598477/full
Autor:
Niu, Shin, Matthew, Stubbs, Holly, Koblish, Eddy W, Yue, Maxim, Soloviev, Brent, Douty, Kathy He, Wang, Qian, Wang, Mingming, Gao, Patricia, Feldman, Gengjie, Yang, Leslie, Hall, Michael, Hansbury, Sybil, O'Connor, Lynn, Leffet, Robert, Collins, Kamna, Katiyar, Xin, He, Paul, Waeltz, Paul, Collier, Jin, Lu, Yun-Long, Li, Yanlong, Li, Phillip C C, Liu, Timothy, Burn, Maryanne, Covington, Sharon, Diamond, Dana, Shuey, Alan, Roberts, Swamy, Yeleswaram, Greg, Hollis, Brian, Metcalf, Wenqing, Yao, Reid, Huber, Andrew, Combs, Robert, Newton, Peggy, Scherle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(1)
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14a526e7b4c814d8f260a1bead68f92f
https://pubmed.ncbi.nlm.nih.gov/32345620
https://pubmed.ncbi.nlm.nih.gov/32345620
Autor:
Sharon Diamond, Kamna Katiyar, Qian Wang, Andrew P. Combs, Holly Koblish, Gengjie Yang, Jordan S. Fridman, Maryanne B. Covington, Gregory Hollis, Yanlong Li, Jun Li, Swamy Yeleswaram, Xin He, Reid Huber, Yun-Long Li, Lynn Leffet, Mark Rupar, Kathy Wang, Dana Shuey, Wenqing Yao, Leslie Hall, Maxim Soloviev, Kevin Bowman, Robert C. Newton, Mike Liu, Margaret F. Favata, Peggy Scherle, Timothy Burn, Kris Vaddi, Beth Rumberger, Song Mei, Niu Shin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 364:120-130
Phosphatidylinositol 3-kinase delta (PI3Kδ) is a critical signaling molecule in B cells and is considered a target for development of therapies against various B cell malignancies. INCB040093 is a novel PI3Kδ small-molecule inhibitor and has demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95263249a805825553343b41c10e5cf4
https://doi.org/10.1124/jpet.117.244947
https://doi.org/10.1124/jpet.117.244947
Autor:
Swamy Yeleswaram, Thomas Maduskuie, Brian Wayland, Hao Feng, Patricia Feldman, Niu Shin, Yanlong Li, Chu-Biao Xue, Peggy Scherle, Song Mei, Kathy Wang, Maryanne Covington, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Wenyu Zhu, Xin He, Sharon Diamond, Eddy W. Yue, Chunhong He, Brian Metcalf, Holly Koblish, Ke Zhang, Nikoo Falahatpisheh, Brent Douty, Leslie Hall, Yu Li, Andrew P. Combs, Joseph Glenn, Kamna Katiyar, Yun-Long Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clinical candidate INCB050465 (20, parsaclisib). The unique structure of 20 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb077aa93316c89804bca15aea78a20
https://pubmed.ncbi.nlm.nih.gov/31749910
https://pubmed.ncbi.nlm.nih.gov/31749910
Autor:
Niu, Shin, Yun-Long, Li, Song, Mei, Kathy He, Wang, Leslie, Hall, Kamna, Katiyar, Qian, Wang, Gengjie, Yang, Beth, Rumberger, Lynn, Leffet, Xin, He, Mark, Rupar, Kevin, Bowman, Margaret, Favata, Jun, Li, Mike, Liu, Yanlong, Li, Maryanne, Covington, Holly, Koblish, Maxim, Soloviev, Dana, Shuey, Timothy, Burn, Sharon, Diamond, Jordan, Fridman, Andrew, Combs, Wenqing, Yao, Swamy, Yeleswaram, Gregory, Hollis, Kris, Vaddi, Reid, Huber, Robert, Newton, Peggy, Scherle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 364(1)
Phosphatidylinositol 3-kinase delta (PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::baeaea6f34f538a85fee066a6746ba98
https://pubmed.ncbi.nlm.nih.gov/29127109
https://pubmed.ncbi.nlm.nih.gov/29127109
Autor:
Lingkai Weng, Qiyan Lin, Ravi Kumar Jalluri, Eric Shi, Maryanne Covington, Ding-Quan Qian, Peggy Scherle, Timothy Burn, Jordan S. Fridman, Kamna Katiyar, Costas Agrios, Max Pan, Kris Vaddi, Changnian Liu, Zelda Wasserman, Nancy Taylor, Eian Caulder, Wenqing Yao, Robert C. Newton, Gregory Hollis, Steven Friedman, Yanlong Li, Bing-Bing Zhou, Yun-Long Li, Michael J. Bower, Chunhong He, Xiangdong Liu, Colin Zhang, Jincong Zhuo, Meizhong Xu, Swamy Yeleswaram, David M. Burns, Cindy A. Marando, Richard Wynn, Brian Metcalf
Publikováno v:
Journal of Medicinal Chemistry. 50:603-606
The design, synthesis, evaluation, and identification of a novel class of (6S,7S)-N-hydroxy-6-carboxamide-5-azaspiro[2.5]octane-7-carboxamides as the first potent and selective inhibitors of human epidermal growth factor receptor-2 (HER-2) sheddase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef3a8ed08b12286d84bda86fa256d1
https://doi.org/10.1021/jm061344o
https://doi.org/10.1021/jm061344o
Autor:
Yun-Long Li, Brian Metcalf, Richard Wynn, Mark Stow, Yanlong Li, Qiyan Lin, Kamna Katiyar, Eric Shi, Costas Agrios, Vaqar Sharief, Lingkai Weng, Reid Huber, Steven M. Friedman, Peggy A. Scherle, Timothy Burn, Xiangdong Liu, Meizhong Xu, Gregory F. Hollis, Colin Zhang, David M. Burns, Dawn Ellis, Robert Newton, Phillip Liu, Cindy Marando, Maryanne B. Covington, Chunhong He, M.C. Hillman, Gengjie Yang, Jincong Zhuo, Mark Rupar, Ding-Quan Qian, Wenqing Yao, Kenneth Abremski, Jodi D. Bradley
Publikováno v:
Cancer Biology & Therapy. 5:657-664
Overexpression and activating mutations of ErbB family members have been implicated in the development and progression of a variety of tumor types. Cleavage of the HER2 receptor by an as yet unidentified ectodomain sheddase has been shown to liberate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c435ae0c30ea356f73c04aba227fa78d
https://doi.org/10.4161/cbt.5.6.2708
https://doi.org/10.4161/cbt.5.6.2708