Výsledky vyhledávání

Species differences in thein vitrometabolism of methapyrilene

Autor: Schmitz Da, Kammerer Rc

Publikováno v: Xenobiotica. 17:1121-1130

1. The metabolism of N,N-dimethyl-N'-(2-pyridyl)-N'-(2-thienylmethyl)-1,2- ethanediamine(methapyrilene, I) by liver microsomes from rat, guinea pig, and rabbit has been examined. 2. Methapyrilene-N-oxide, (III), normethapyrilene, (II), 2-thiophene me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c918b915bd3418807cb02d34b43fce6f
https://doi.org/10.3109/00498258709044211

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Induction of phencyclidine metabolism by phencyclidine, ketamine, ethanol, phenobarbital and isosafrole

Autor: Kammerer Rc, Hwa Jj, Debra A. Schmitz, Arthur K. Cho

Publikováno v: Biochemical pharmacology. 33(4)

The in vitro metabolism of phencyclidine (PCP) was investigated in 9000 g supernatant fractions of both control and PCP-, ketamine-, ethanol-, phenobarbital- or isosafrole-pretreated rats. Levels of PCP, trans -4-phenyl-4-piperidinocyclohexanol (I),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879f6fb84eda85177f7cb7501a2dc05b
https://pubmed.ncbi.nlm.nih.gov/6704176

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Demonstration of an amino acid metabolite of phencyclidine

Autor: Wilkins J, Gosenfeld L, Cohen Ls, Kammerer Rc, Tachiki K

Publikováno v: The New England journal of medicine. 306(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ac4631b14b39b9508effbb0e3b5a45
https://pubmed.ncbi.nlm.nih.gov/7078587

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The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat

Autor: Kloc K, Lampe Ma, Debra A. Schmitz, Kammerer Rc

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 18(7)

1. The metabolism of methapyrilene (I), was examined in vivo by g.l.c. and g.l.c.-mass spectrometric analysis of rat urinary extracts. 2. Dosing the animals with tetradeuterium-labelled I helped identify 7 different metabolites of I in the urine, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187d473fab04db2910b85601d8b2bd40
https://pubmed.ncbi.nlm.nih.gov/3176524

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In vitro metabolism of chlorpheniramine in the rabbit

Autor: Kammerer Rc, Lampe Ma

Publikováno v: Biochemical pharmacology. 36(20)

The in vitro metabolism of 3-(p-chlorophenyl)-3-(2-pyridyl)-N, N-dimethylpropylamine (chlorpheniramine, I) by rabbit liver microsomes was examined. The metabolites, tentatively identified by gas-liquid chromatography-mass spectrometry, included the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a107b8084c02fd1fdf23ef95d1700d
https://pubmed.ncbi.nlm.nih.gov/3675607

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Akademický článek

Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster.

Autor: Lampe MA; Department of Pharmacology, School of Medicine, University of California, Los Angeles 90024., Kammerer RC

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 1990 Dec; Vol. 20 (12), pp. 1269-80.

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Akademický článek

Testing for fluoxymesterone (Halotestin) administration to man: identification of urinary metabolites by gas chromatography-mass spectrometry.

Autor: Kammerer RC; Paul Ziffren Olympic Analytical Laboratory, UCLA Department of Pharmacology, School of Medicine 90024., Merdink JL, Jagels M, Catlin DH, Hui KK

Publikováno v: Journal of steroid biochemistry [J Steroid Biochem] 1990 Aug 28; Vol. 36 (6), pp. 659-66.

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