Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kamir J. Hiam"'
Autor:
S. John Liu, Tim Casey-Clyde, Nam Woo Cho, Jason Swinderman, Melike Pekmezci, Mark C. Dougherty, Kyla Foster, William C. Chen, Javier E. Villanueva-Meyer, Danielle L. Swaney, Harish N. Vasudevan, Abrar Choudhury, Joanna Pak, Jonathan D. Breshears, Ursula E. Lang, Charlotte D. Eaton, Kamir J. Hiam-Galvez, Erica Stevenson, Kuei-Ho Chen, Brian V. Lien, David Wu, Steve E. Braunstein, Penny K. Sneed, Stephen T. Magill, Daniel Lim, Michael W. McDermott, Mitchel S. Berger, Arie Perry, Nevan J. Krogan, Marlan R. Hansen, Matthew H. Spitzer, Luke Gilbert, Philip V. Theodosopoulos, David R. Raleigh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the peripheral nervous system. We fin
Externí odkaz:
https://doaj.org/article/6c3cb10a1a664ce0a55f363c96e7591d
Autor:
Michelle B. Atallah, Varun Tandon, Kamir J. Hiam, Hunter Boyce, Michelle Hori, Waleed Atallah, Matthew H. Spitzer, Edgar Engleman, Parag Mallick
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background While technological advances have made it possible to profile the immune system at high resolution, translating high-throughput data into knowledge of immune mechanisms has been challenged by the complexity of the interactions und
Externí odkaz:
https://doaj.org/article/3d0c304faa0748c4886545fd150073bd
Autor:
Shen Dong, Kamir J. Hiam-Galvez, Cody T. Mowery, Kevan C. Herold, Stephen E. Gitelman, Jonathan H. Esensten, Weihong Liu, Angela P. Lares, Ashley S. Leinbach, Michael Lee, Vinh Nguyen, Stanley J. Tamaki, Whitney Tamaki, Courtney M. Tamaki, Morvarid Mehdizadeh, Amy L. Putnam, Matthew H. Spitzer, Chun Jimmie Ye, Qizhi Tang, Jeffrey A. Bluestone
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
BACKGROUND A previous phase I study showed that the infusion of autologous Tregs expanded ex vivo into patients with recent-onset type 1 diabetes (T1D) had an excellent safety profile. However, the majority of the infused Tregs were undetectable in t
Externí odkaz:
https://doaj.org/article/7153605b428a4670a8f2035fe21e7584
Autor:
Bence Daniel, Kathryn E. Yost, Sunnie Hsiung, Katalin Sandor, Yu Xia, Yanyan Qi, Kamir J. Hiam-Galvez, Mollie Black, Colin J. Raposo, Quanming Shi, Stefanie L. Meier, Julia A. Belk, Josephine R. Giles, E. John Wherry, Howard Y. Chang, Takeshi Egawa, Ansuman T. Satpathy
Publikováno v:
Nature Immunology. 23:1614-1627
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62dc4a6c472408069bb3efedb1cfbf10
https://doi.org/10.1038/s41590-022-01337-5
https://doi.org/10.1038/s41590-022-01337-5
Autor:
S. John Liu, Tim Casey-Clyde, Nam Woo Cho, Jason Swinderman, Melike Pekmezci, Mark C. Dougherty, Kyla Foster, William C. Chen, Javier E. Villanueva-Meyer, Danielle L. Swaney, Harish N. Vasudevan, Abrar Choudhury, Jonathan D. Breshears, Ursula E. Lang, Charlotte D Eaton, Kamir J. Hiam-Galvez, Erica Stevenson, Kuei-Ho Chen, Brian V. Lien, David Wu, Steve E. Braunstein, Penny K. Sneed, Stephen T. Magill, Daniel Lim, Michael W. McDermott, Mitchel S. Berger, Arie Perry, Nevan J. Krogan, Marlon Hansen, Matthew H. Spitzer, Luke Gilbert, Philip V. Theodosopoulos, David R. Raleigh
SummaryCell state evolution underlies tumor development and response to therapy1, but mechanisms specifying cancer cell states and intratumor heterogeneity are incompletely understood. Schwannomas are the most common tumors of the peripheral nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6f1b4185d7958479e36fb130929ae6
https://doi.org/10.1101/2022.12.23.521842
https://doi.org/10.1101/2022.12.23.521842
Autor:
Nam Woo Cho, Sophia M. Guldberg, Eun Ji Kim, Kamir J. Hiam-Galvez, Katherine Wai, Lauren S. Levine, Barzin Y. Nabet, Rachel DeBarge, Jacqueline L. Yee, Naa Asheley Ashitey, Iliana Tenvooren, Matthew H. Spitzer
Even in patients whose tumours exhibit increased T cell infiltration, resistance to immune checkpoint inhibitor (ICI) therapy is common. We investigated mechanisms of ICI resistance using engineered mouse models with increased neoantigen burden and T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb603281f9788dc9e6c4674727a9aaf6
https://doi.org/10.1101/2022.09.20.508732
https://doi.org/10.1101/2022.09.20.508732
Autor:
Carlos A. Castellanos, Kamir J. Hiam-Galvez, Satoshi Ishido, Ansuman T. Satpathy, Jeoung-Sook Shin
Publikováno v:
ImmunoHorizons. 6(9)
Persistent antigenic signaling leads to T cell exhaustion, a dysfunctional state arising in many chronic infections and cancers. Little is known concerning mechanisms limiting exhaustion in immune-stimulatory diseases such as asthma. We report that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaa5f578dacc652de5b7dbd3d17b040
https://pubmed.ncbi.nlm.nih.gov/36100368
https://pubmed.ncbi.nlm.nih.gov/36100368
Autor:
Bence Daniel, Kathryn E. Yost, Katalin Sandor, Yu Xia, Yanyan Qi, Kamir J. Hiam-Galvez, Stefanie L. Meier, Julia A. Belk, Josephine R. Giles, E. John Wherry, Howard Y. Chang, Takeshi Egawa, Ansuman T. Satpathy
SUMMARYT cells activated by chronic antigen exposure in the setting of viral infections or cancer can adopt an exhausted T cell (Tex) state, characterized by reduced effector function and proliferative capacity, and the upregulation of inhibitory rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79b6659d88541b1c922c0c66cebbfe62
https://doi.org/10.1101/2021.12.16.472900
https://doi.org/10.1101/2021.12.16.472900
Autor:
Bence, Daniel, Kathryn E, Yost, Sunnie, Hsiung, Katalin, Sandor, Yu, Xia, Yanyan, Qi, Kamir J, Hiam-Galvez, Mollie, Black, Colin, J Raposo, Quanming, Shi, Stefanie L, Meier, Julia A, Belk, Josephine R, Giles, E John, Wherry, Howard Y, Chang, Takeshi, Egawa, Ansuman T, Satpathy
Publikováno v:
Nature immunology. 23(11)
Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell (Tex) state with reduced effector function. However, whether all antigen-specific T cell clones follow the same Tex differentiation trajectory remains unclear. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71ad098f260d45a98a032770b095053f
https://pubmed.ncbi.nlm.nih.gov/36289450
https://pubmed.ncbi.nlm.nih.gov/36289450
Autor:
Kamir J Hiam-Galvez, Caleb A. Lareau, Rachel DeBarge, Trine Line Okholm, Matthew H. Spitzer, Jacqueline Yee, Nam Woo Cho
The precise timing of T cell priming during infection remains unclear. Here, we mapped the cellular dynamics of all immune lineages during acute infection with Listeria monocytogenes (Lm). We identified highly transient DC activation 2 days post-infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685687b74e9dbcc2ccc3141e8dcd4355
https://doi.org/10.21203/rs.3.rs-1013987/v1
https://doi.org/10.21203/rs.3.rs-1013987/v1