C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

Autor: Lautenschlager J., Stephens A. D., Fusco G., Strohl F., Curry N., Zacharopoulou M., Michel C. H., Laine R., Nespovitaya N., Fantham M., Pinotsi D., Zago W., Fraser P., Tandon A., St George-Hyslop P., Rees E., Phillips J. J., De Simone A., Kaminski C. F., Schierle G. S. K.

Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, therewith increasing its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::8728276fbed7b33a3efa24c398f64cc6
http://hdl.handle.net/11588/839285

Intrinsically disordered proteins as molecular shields

Autor: Chakrabortee, S, Tripathi, R, Watson, M, Kaminski Schierle, G. S, Kurniawan, D. P, Kaminski, C. F, Wise, M. J. and Tunnacliffe, A., Chakrabortee, S., Tripathi, R., Watson, M., Kaminski Schierle, G. S., Kurniawan, D. P., Kaminski, C. F., Wise, M. J., Tunnacliffe, A.

Publikováno v: Molecular BioSystems.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::ac911ec027bb2da79f1bc4639b17fc90

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

Autor: Michel, C. H., Kumar, S., Pinotsi, D., Tunnacliffe, A., St. George-Hyslop, P., Mandelkow, E., Mandelkow, E.-M., Kaminski, C. F., Kaminski Schierle, G. S.

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry
The journal of biological chemistry 289(2), 956-967 (2013). doi:10.1074/jbc.M113.515445

Background: The aggregation and stereotypic spreading of Tau protein is associated with Alzheimer disease. Results: Monomeric Tau enters neurons and nucleates and engages endogenous Tau to aggregate. Conclusion: Endocytosis of soluble Tau triggers ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0fdf02f62a1c6798f3141c249adb75f
https://pubmed.ncbi.nlm.nih.gov/24235150

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Novel laser techniques for diagnostics of plasmas and flames

Autor: Kaminski, C. F.

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294362