Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kamil Wdowiak"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 999 (2024)
Curcumin and piperine are plant compounds known for their health-promoting properties, but their use in the prevention or treatment of various diseases is limited by their poor solubility. To overcome this drawback, the curcumin–piperine amorphous
Externí odkaz:
https://doaj.org/article/652fb6d4d95f4090b0a339369514635f
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 659 (2024)
The co-administration of curcumin and hesperetin might be beneficial in terms of neuroprotective activity; therefore, in this study, we attempted to develop a fixed-dose formulation comprising these two compounds in an amorphous state. The aim of obt
Externí odkaz:
https://doaj.org/article/f952be1be882468195f7b55fe40d0b47
Publikováno v:
Molecules, Vol 28, Iss 9, p 3848 (2023)
Poor bioavailability hampers the use of curcumin and piperine as biologically active agents. It can be improved by enhancing the solubility as well as by using bioenhancers to inhibit metabolic transformation processes. Obtaining an amorphous system
Externí odkaz:
https://doaj.org/article/55398fca90534d94a842c8a1debddbf1
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4859 (2023)
The low bioaccessibility of hesperetin and piperine hampers their application as therapeutic agents. Piperine has the ability to improve the bioavailability of many compounds when co-administered. The aim of this paper was to prepare and characterize
Externí odkaz:
https://doaj.org/article/2475491bfdd54ddf84256dec5546af6a
Publikováno v:
Saudi Journal of Kidney Diseases and Transplantation, Vol 32, Iss 2, Pp 548-553 (2021)
Kaposi’s sarcoma (KS), one of the most typical malignancies after kidney transplantation, is strongly associated with human herpes virus 8 infection. More than 90% of patients had primary skin changes, which make the diagnosis easier and faster. Th
Externí odkaz:
https://doaj.org/article/8141edc9213c48e79b7a1e3b4d54f056
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15198 (2022)
The present study reports amorphous solid dispersions (ASDs) of hesperidin (Hes) prepared by ball milling to improve its solubility and apparent solubility over the unmodified compound. The carriers were Soluplus® (Sol), alginate sodium (SA), and hy
Externí odkaz:
https://doaj.org/article/403393d020724065b26790047188be99
Autor:
Kamil Wdowiak, Jarosław Walkowiak, Robert Pietrzak, Aleksandra Bazan-Woźniak, Judyta Cielecka-Piontek
Publikováno v:
Nutrients, Vol 14, Iss 13, p 2647 (2022)
Hesperidin and hesperetin are polyphenols that can be found predominantly in citrus fruits. They possess a variety of pharmacological properties such as neuroprotective and antidiabetic activity. However, the bioavailability of these compounds is lim
Externí odkaz:
https://doaj.org/article/f17c0adf2785452b8e93553641147e8e
Autor:
Kamil Wdowiak, Natalia Rosiak, Ewa Tykarska, Marcin Żarowski, Anita Płazińska, Wojciech Płaziński, Judyta Cielecka-Piontek
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4000 (2022)
This study aimed at obtaining hesperidin (Hed) and hesperetin (Het) systems with HP-β-CD by means of the solvent evaporation method. The produced systems were identified using infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD), and diffe
Externí odkaz:
https://doaj.org/article/2aab1e0822944dcc93813adebf68c698
Autor:
Gabriela Wiergowska, Dominika Ludowicz, Kamil Wdowiak, Andrzej Miklaszewski, Kornelia Lewandowska, Judyta Cielecka-Piontek
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 453 (2021)
To improve physicochemical properties of vardenafil hydrochloride (VAR), its amorphous form and combinations with excipients—hydroxypropyl methylcellulose (HPMC) and β-cyclodextrin (β-CD)—were prepared. The impact of the modification on physico
Externí odkaz:
https://doaj.org/article/5be6819d9d334d27841a0decc9a1c0c4
Autor:
Kamil Pawłowicz, Dominika Ludowicz, Marta Karaźniewicz-Łada, Kamil Wdowiak, Judyta Cielecka-Piontek
Publikováno v:
Molecules, Vol 26, Iss 11, p 3204 (2021)
The aim of the study is to evaluate the composition of lyophilisates obtained from Aloe arborescens leaf gel at the age of one to four years. The leaves were obtained from controlled crops, which allowed to exclude environmental factors as variables.
Externí odkaz:
https://doaj.org/article/60292be8d3a44d54bd6dc11c7fa96f7f