Anabolic Steroids Activate the NF-κB Pathway in Porcine Ovarian Putative Stem Cells Independently of the ZIP-9 Receptor

Autor: Kamil Wartalski, Jerzy Wiater, Patrycja Maciak, Agnieszka Pastuła, Grzegorz J. Lis, Marcin Samiec, Monika Trzcińska, Małgorzata Duda

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 5, p 2833 (2024)

Boldenone (Bdn) and nandrolone (Ndn) are anabolic androgenic steroids (AASs) that, as our previous studies have shown, may increase the risk of neoplastic transformation of porcine ovarian putative stem cells (poPSCs). The NF-κB pathway may be impor

Externí odkaz: https://doaj.org/article/6cf9ac28b31748b694f15881277c13c7

The Molecular Quality and Mitochondrial Activity of Porcine Cumulus–Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions

Autor: Gabriela Gorczyca, Kamil Wartalski, Marek Romek, Marcin Samiec, Małgorzata Duda

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 9, p 4572 (2022)

Thus far, the potential short- and long-term detrimental effects of a variety of environmental chemicals designated as endocrine-active compounds (EACs) have been found to interfere with histo- and anatomo-physiological functions of the reproductive

Externí odkaz: https://doaj.org/article/17491ff732ac4cf790061b0fee75fef0

Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing Human FUT2 and GLA Genes—In Vitro Studies

Autor: Jerzy Wiater, Marcin Samiec, Kamil Wartalski, Zdzisław Smorąg, Jacek Jura, Ryszard Słomski, Maria Skrzyszowska, Marek Romek

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 18, p 9683 (2021)

Pig-to-human xenotransplantation seems to be the response to the contemporary shortage of tissue/organ donors. Unfortunately, the phylogenetic distance between pig and human implies hyperacute xenograft rejection. In this study, we tested the hypothe

Externí odkaz: https://doaj.org/article/bb8816e585a8485bbb927491718fb535

Anabolic Steroids-Driven Regulation of Porcine Ovarian Putative Stem Cells Favors the Onset of Their Neoplastic Transformation

Autor: Jerzy Wiater, Kamil Wartalski, Marcin Samiec, Gabriela Gorczyca, Zbigniew Tabarowski, Malgorzata Duda

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11800, p 11800 (2021)

Nandrolone (Ndn) and boldenone (Bdn), the synthetic testosterone analogues with strong anabolic effects, despite being recognized as potentially carcinogenic compounds, are commonly abused by athletes and bodybuilders, which includes women, worldwide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6963fa3058f551e6f560d00e2ce100ce
https://pubmed.ncbi.nlm.nih.gov/34769230

Porcine ovarian cortex-derived putative stem cells can differentiate into endothelial cells in vitro

Autor: Jerzy Wiater, Malgorzata Duda, Gabriela Gorczyca, Zbigniew Tabarowski, Kamil Wartalski

Publikováno v: Histochemistry and Cell Biology

Endothelial cells (ECs), the primary component of the vasculature, play a crucial role in neovascularization. However, the number of endogenous ECs is inadequate for both experimental purposes and clinical applications. Porcine ovarian putative stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b145ffcd14c263975ae9828d3c1eafd
https://pubmed.ncbi.nlm.nih.gov/34269874