Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Kamil Paruch"'
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound
Externí odkaz:
https://doaj.org/article/3eace71e4f774decb598d79c690ed3aa
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a3f8e3d5b4894e4aa4350454d71f0f4e
Autor:
Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Jana Cerna, Alexandra Oltova, Vaclav Seda, Marek Mraz, Josef Jaros, Zuzana Jaskova, Michaela Spunarova, Yvona Brychtova, Karel Soucek, Stanislav Drapela, Marie Kasparkova, Jiri Mayer, Kamil Paruch, Martin Trbusek
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment discontinuation
Externí odkaz:
https://doaj.org/article/e872ad7d936f40299c20d4bb02b9ef06
Autor:
Jarmila Herůdková, Kamil Paruch, Prashant Khirsariya, Karel Souček, Martin Krkoška, Olga Vondálová Blanářová, Petr Sova, Alois Kozubík, Alena Hyršlová Vaculová
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 830-841 (2017)
Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of an
Externí odkaz:
https://doaj.org/article/e81b0f5a2c1d4cceb65c2243075f3a24
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7549 (2020)
Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the la
Externí odkaz:
https://doaj.org/article/c18a3804af3d4443ae512a3cc9d08c69
Autor:
Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Externí odkaz:
https://doaj.org/article/e7bcbdc4ad754e1e8d403ed31b65297e
Autor:
David Parry, Ming Liu, Suining Lee, Yunsheng Hsieh, Danling Gu, Wei Wang, Bhagyashree Bhagwat, Ervin Penaflor, Wolfgang Seghezzi, Derek Wiswell, Lorena Taricani, Nicole Davis, Frances Shanahan, Marc Labroli, Michael P. Dwyer, Kamil Paruch, Timothy J. Guzi
Supplementary Table 7 from Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08467be88e5ae6f26a63e170eb49e9e8
https://doi.org/10.1158/1535-7163.22502688.v1
https://doi.org/10.1158/1535-7163.22502688.v1
Autor:
David Parry, Ming Liu, Suining Lee, Yunsheng Hsieh, Danling Gu, Wei Wang, Bhagyashree Bhagwat, Ervin Penaflor, Wolfgang Seghezzi, Derek Wiswell, Lorena Taricani, Nicole Davis, Frances Shanahan, Marc Labroli, Michael P. Dwyer, Kamil Paruch, Timothy J. Guzi
Supplementary Figure 1 from Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5bd4321320341097db170c455b546c
https://doi.org/10.1158/1535-7163.22502796
https://doi.org/10.1158/1535-7163.22502796
Autor:
David Parry, Ming Liu, Suining Lee, Yunsheng Hsieh, Danling Gu, Wei Wang, Bhagyashree Bhagwat, Ervin Penaflor, Wolfgang Seghezzi, Derek Wiswell, Lorena Taricani, Nicole Davis, Frances Shanahan, Marc Labroli, Michael P. Dwyer, Kamil Paruch, Timothy J. Guzi
Supplementary Table 4 from Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148621f57e4e535a39b5f2b12408413d
https://doi.org/10.1158/1535-7163.22502715.v1
https://doi.org/10.1158/1535-7163.22502715.v1