Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Kamil Kuder"'
Autor:
Shilu Deepa Thomas, Petrilla Jayaprakash, Nurfirzana Z. H. J. Marwan, Ezzatul A. B. A. Aziz, Kamil Kuder, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1293 (2024)
Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social interaction difficulties, repetitive behaviors, and immune dysregulation with elevated pro-inflammatory markers. Autophagic deficiency also contr
Externí odkaz:
https://doaj.org/article/af8ed22bcf404b21bcf48a73526b5b72
Autor:
Kamil Mika, Małgorzata Szafarz, Marek Bednarski, Kamil Kuder, Katarzyna Szczepańska, Krzysztof Pociecha, Bartosz Pomierny, Katarzyna Kieć-Kononowicz, Jacek Sapa, Magdalena Kotańska
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111952- (2021)
Aims: One of the therapeutic approaches in the treatment of obesity is the use of histamine H3 receptor ligands. Histamine plays a significant role in eating behavior because it causes a loss of appetite and is considered to be a satiety signal relea
Externí odkaz:
https://doaj.org/article/6a3c5ca87e4d48f58209fd85d18e7a2d
Publikováno v:
Current Medicinal Chemistry. 28:2974-2995
With the recent market approval of Pitolisant (Wakix®), the interest in clinical application for novel multifunctional histamine H3 receptor antagonists has clearly increased. Several combinations of different H3R pharmacophores with pharmacophoric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e4227ea29dabb8d8c83d35dc402506
https://doi.org/10.2174/0929867327666200806103144
https://doi.org/10.2174/0929867327666200806103144
Autor:
Katarzyna Szczepańska, Krzysztof Pociecha, Marek Bednarski, Magdalena Kotańska, Małgorzata Szafarz, Kamil Mika, Bartosz Pomierny, Jacek Sapa, Kamil Kuder, Katarzyna Kieć-Kononowicz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111952-(2021)
Aims One of the therapeutic approaches in the treatment of obesity is the use of histamine H3 receptor ligands. Histamine plays a significant role in eating behavior because it causes a loss of appetite and is considered to be a satiety signal releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9c4768d294b9e0088bd8a28d607f73
http://www.sciencedirect.com/science/article/pii/S0753332221007344
http://www.sciencedirect.com/science/article/pii/S0753332221007344
Autor:
Katarzyna Kieć-Kononowicz, Bartłomiej Kubas, Małgorzata Zygmunt, Miriam Schlenk, Gniewomir Latacz, Kamil Kuder, Tadeusz Karcz, Sonja Hinz, David Synak, Agnieszka Olejarz-Maciej, Christa E. Müller, Jakub Schabikowski, Michał Załuski
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1195-1210
N9-Benzyl-substituted imidazo-, pyrimido- and 1,3-diazepino[2,1-f]purinediones were designed as dual-target-directed ligands combining A2A adenosine receptor (AR) antagonistic activity with blockade of monoamine oxidase B (MAO-B). A library of 37 nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aecaba84ea51194ae88630bc5f26d61
https://doi.org/10.1016/j.bmc.2019.02.004
https://doi.org/10.1016/j.bmc.2019.02.004
Autor:
Kamil, Mika, Małgorzata, Szafarz, Marek, Bednarski, Kamil, Kuder, Katarzyna, Szczepańska, Krzysztof, Pociecha, Bartosz, Pomierny, Katarzyna, Kieć-Kononowicz, Jacek, Sapa, Magdalena, Kotańska
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 142
One of the therapeutic approaches in the treatment of obesity is the use of histamine HHistamine ligands were selected based on the preliminary studies which included determination of intrinsic activity and selected pharmacokinetic parameters. Female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5da9200f9e3931adf7d2d29e561557b
https://pubmed.ncbi.nlm.nih.gov/34325303
https://pubmed.ncbi.nlm.nih.gov/34325303
Autor:
Katarzyna Kieć-Kononowicz, Kamil Mika, Holger Stark, Magdalena Kotańska, Katarzyna Szczepańska, Kamil Kuder, David Reiner-Link
Publikováno v:
Molecules
Molecules, Vol 26, Iss 2300, p 2300 (2021)
Volume 26
Issue 8
Molecules, Vol 26, Iss 2300, p 2300 (2021)
Volume 26
Issue 8
In an attempt to find new dual acting histamine H3 receptor (H3R) ligands, we designed a series of compounds, structurally based on previously described in our group, a highly active and selective human histamine H3 receptor (hH3R) ligand KSK63. As a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2e8c45d5002916ba2fa0c2d35516e8
http://europepmc.org/articles/PMC8071534
http://europepmc.org/articles/PMC8071534
Autor:
Gniewomir Latacz, Sylwia Sudoł, Katarzyna Kieć-Kononowicz, Małgorzata Szafarz, Kamil Mika, Joanna Knutelska, Katarzyna Szczepańska, Marek Bednarski, Kamil Kuder, Magdalena Kotańska, Jadwiga Handzlik, Noemi Nicosia, Krzysztof Pociecha
Publikováno v:
Pharmaceuticals
Volume 14
Issue 11
Pharmaceuticals, Vol 14, Iss 1080, p 1080 (2021)
Volume 14
Issue 11
Pharmaceuticals, Vol 14, Iss 1080, p 1080 (2021)
Noting the worldwide rapid increase in the prevalence of overweight and obesity new effective drugs are now being sought to combat these diseases. Histamine H3 receptor antagonists may represent an effective therapy as they have been shown to modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb8645b82eb7afbaf266c2bc1e84808
https://ruj.uj.edu.pl/xmlui/handle/item/283819
https://ruj.uj.edu.pl/xmlui/handle/item/283819
Autor:
Dorota, Łażewska, Marek, Bajda, Maria, Kaleta, Paula, Zaręba, Agata, Doroz-Płonka, Agata, Siwek, Alaa, Alachkar, Szczepan, Mogilski, Ali, Saad, Kamil, Kuder, Agnieszka, Olejarz-Maciej, Justyna, Godyń, Dorota, Stary, Sylwia, Sudoł, Małgorzata, Więcek, Gniewomir, Latacz, Maria, Walczak, Jadwiga, Handzlik, Bassem, Sadek, Barbara, Malawska, Katarzyna, Kieć-Kononowicz
Publikováno v:
European journal of medicinal chemistry. 207
Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer's disease (AD). In our present research, a number of xanthone derivatives were first designed using a pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19b9ce0cd6668a224d31e97fea8dca07
https://pubmed.ncbi.nlm.nih.gov/32882609
https://pubmed.ncbi.nlm.nih.gov/32882609
Autor:
Michał, Załuski, Jakub, Schabikowski, Piotr, Jaśko, Adrian, Bryła, Agnieszka, Olejarz-Maciej, Maria, Kaleta, Monika, Głuch-Lutwin, Andreas, Brockmann, Sonja, Hinz, Małgorzata, Zygmunt, Kamil, Kuder, Gniewomir, Latacz, Christin, Vielmuth, Christa E, Müller, Katarzyna, Kieć-Kononowicz
Publikováno v:
Bioorganic chemistry. 101
A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and benzyloxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a009e749db46e7c0188b2c8bdd165b6c
https://pubmed.ncbi.nlm.nih.gov/32629282
https://pubmed.ncbi.nlm.nih.gov/32629282