Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kamil J, Kuder"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10652 (2024)
Perry disease (PeD) is a rare, neurodegenerative, genetic disorder inherited in an autosomal dominant manner. The disease manifests as parkinsonism, with psychiatric symptoms on top, such as depression or sleep disorders, accompanied by unexpected we
Externí odkaz:
https://doaj.org/article/232be020a7e84cecb6a8035996edbfbe
Autor:
Anna Stasiak, Ewelina Honkisz-Orzechowska, Zbigniew Gajda, Waldemar Wagner, Katarzyna Popiołek-Barczyk, Kamil J. Kuder, Gniewomir Latacz, Michał Juszczak, Katarzyna Woźniak, Tadeusz Karcz, Katarzyna Szczepańska, Marta Jóźwiak-Bębenista, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8035 (2024)
The future of therapy for neurodegenerative diseases (NDs) relies on new strategies targeting multiple pharmacological pathways. Our research led to obtaining the compound AR71 [(E)-3-(3,4,5-trimethoxyphenyl)-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)pr
Externí odkaz:
https://doaj.org/article/07f15c28e5634125bbc9b416bd8c2a3d
Autor:
Michał Załuski, Dorota Łażewska, Piotr Jaśko, Ewelina Honkisz-Orzechowska, Kamil J. Kuder, Andreas Brockmann, Gniewomir Latacz, Małgorzata Zygmunt, Maria Kaleta, Beril Anita Greser, Agnieszka Olejarz-Maciej, Magdalena Jastrzębska-Więsek, Christin Vielmuth, Christa E. Müller, Katarzyna Kieć-Kononowicz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13707 (2023)
Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson’s disease (PD). In the present study, we synthesized 25 novel xanthine derivatives with variable substituents at the N1-, N3- and C8-po
Externí odkaz:
https://doaj.org/article/5963438b8d354c9ba124160cee724d87
Autor:
Sabna Abdalla, Nermin Eissa, Petrilla Jayaprakash, Rami Beiram, Kamil J. Kuder, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12719 (2023)
The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s disease (AD), is well-accepted. Therefore, the procognitive effects of acute sys
Externí odkaz:
https://doaj.org/article/23e23af10ddb4356b05b65ab4d10e065
Autor:
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Publikováno v:
Molecules, Vol 28, Iss 1, p 238 (2022)
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a nove
Externí odkaz:
https://doaj.org/article/2481fe283dea45f89bc7efb49683033f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7917 (2022)
The GPR18 receptor, often referred to as the N-arachidonylglycine receptor, although assigned (along with GPR55 and GPR119) to the new class A GPCR subfamily-lipid receptors, officially still has the status of a class A GPCR orphan. While its signali
Externí odkaz:
https://doaj.org/article/5a720110e68944568cb58f660520ec19
Autor:
Kamil Mika, Małgorzata Szafarz, Marek Bednarski, Gniewomir Latacz, Sylwia Sudoł, Jadwiga Handzlik, Krzysztof Pociecha, Joanna Knutelska, Noemi Nicosia, Katarzyna Szczepańska, Kamil J. Kuder, Katarzyna Kieć-Kononowicz, Magdalena Kotańska
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1080 (2021)
Noting the worldwide rapid increase in the prevalence of overweight and obesity new effective drugs are now being sought to combat these diseases. Histamine H3 receptor antagonists may represent an effective therapy as they have been shown to modulat
Externí odkaz:
https://doaj.org/article/4a2cda7eb07b4e9996441514b99f7a6c
Autor:
Kamil J. Kuder, Magdalena Kotańska, Katarzyna Szczepańska, Kamil Mika, David Reiner-Link, Holger Stark, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 26, Iss 8, p 2300 (2021)
In an attempt to find new dual acting histamine H3 receptor (H3R) ligands, we designed a series of compounds, structurally based on previously described in our group, a highly active and selective human histamine H3 receptor (hH3R) ligand KSK63. As a
Externí odkaz:
https://doaj.org/article/f6dc552355194124acf7001217757fb2
Autor:
Kamil, Mika, Małgorzata, Szafarz, Marek, Bednarski, Gniewomir, Latacz, Sylwia, Sudoł, Jadwiga, Handzlik, Krzysztof, Pociecha, Joanna, Knutelska, Noemi, Nicosia, Katarzyna, Szczepańska, Kamil J, Kuder, Katarzyna, Kieć-Kononowicz, Magdalena, Kotańska
Publikováno v:
Pharmaceuticals
Noting the worldwide rapid increase in the prevalence of overweight and obesity new effective drugs are now being sought to combat these diseases. Histamine H3 receptor antagonists may represent an effective therapy as they have been shown to modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3507dcb5c5ab08e7244d98cf0f603d3
https://pubmed.ncbi.nlm.nih.gov/34832862
https://pubmed.ncbi.nlm.nih.gov/34832862
Autor:
Katarzyna, Szczepańska, Steffen, Pockes, Sabina, Podlewska, Carina, Höring, Kamil, Mika, Gniewomir, Latacz, Marek, Bednarski, Agata, Siwek, Tadeusz, Karcz, Martin, Nagl, Merlin, Bresinsky, Denise, Mönnich, Ulla, Seibel, Kamil J, Kuder, Magdalena, Kotańska, Holger, Stark, Sigurd, Elz, Katarzyna, Kieć-Kononowicz
Publikováno v:
European journal of medicinal chemistry. 213
A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved to be potent histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::714d1f27b2325a285b137f0d7134bbec
https://pubmed.ncbi.nlm.nih.gov/33261900
https://pubmed.ncbi.nlm.nih.gov/33261900