Výsledky vyhledávání - "Kamil Hrubý"

Biotransformation of Benfluron by Rat Hepatic Cytochrome P450. Identification of Individual CYP-Enzymes Involved in Biotransformation of Benfluron, Prospective Antineoplastic Based on Benzo[c]fluorene

Autor: Pavel Anzenbacher, Eva Anzenbacherová, Kamil Hrubý, Milan Nobilis

Publikováno v: Collection of Czechoslovak Chemical Communications. 65:1374-1386

Benfluron, 5-[2-(dimethylamino)ethoxy]-7H-benzo[c]fluoren-7-one hydrochloride, a prospective antineoplastic agent, is metabolised by cytochromes P450 toN-demethyl and 9-hydroxy derivatives. To prove the participation of individual cytochrome P450 iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::750053dbaf514e4b8aac3737ee1d2651
https://doi.org/10.1135/cccc20001374

Zobrazit plný text záznamu

Study of the biotransformation of a potential benzo[c]fluorene antineoplastic using high-performance liquid chromatography with high-speed-scanning ultraviolet detection

Autor: Milan Nobilis, Pavel Anzenbacher, František Trejtnar, Jaroslav Květina, Kamil Hrubý, Jiří Pastera, Karel Ubik, Zbyněk Svoboda

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 681:143-151

As the sum of benfluron metabolites found was only a part of the total amount applied, a search for undiscovered metabolites was undertaken in the extracts from isolated rat hepatocytes and in the bile and perfusate in the experiments with an isolate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d209d5d944da9f7c226cce4ee004274a
https://doi.org/10.1016/0378-4347(95)00523-4

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání