Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kamil Łątka"'
Autor:
Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Piotr Szymczyk, Grzegorz Galita, Jacek Kabziński, Ireneusz Majsterek, Alba Espargaró, Raimon Sabate, Paweł Szymański
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Alzheimer’s disease (AD) is a progressive neurodegenerative brain disease. Thus, drugs including donepezil, rivastigmine, and galantamine are not entirely effective in the treatment of this multifactorial disease. The present study evaluates eight
Externí odkaz:
https://doaj.org/article/45d56f22c80743759b64fd4e3c5eda6c
Autor:
Kamil Łątka, Marek Bajda
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1663 (2022)
The recently obtained cryo-electron microscopy structure (PDB code: 7SK2) of the human γ-aminobutyric acid transporter type 1 (hGAT-1) in complex with the antiepileptic drug, tiagabine, revealed a rather unexpected binding mode for this inhibitor in
Externí odkaz:
https://doaj.org/article/2775b3ffd9f140c68dc542526e37c7b4
Autor:
Paulina Chałupnik, Alina Vialko, Darryl S. Pickering, Markus Hinkkanen, Stephanie Donbosco, Thor C. Møller, Anders A. Jensen, Birgitte Nielsen, Yasmin Bay, Anders S. Kristensen, Tommy N. Johansen, Kamil Łątka, Marek Bajda, Ewa Szymańska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8797 (2022)
Kainate receptors belong to the family of glutamate receptors ion channels, which are responsible for the majority of rapid excitatory synaptic transmission in the central nervous system. The therapeutic potential of kainate receptors is still poorly
Externí odkaz:
https://doaj.org/article/41bc4f7161f44d6e92ef3e5cfa67ab09
Autor:
Kamil Łątka, Marek Bajda
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 8050 (2022)
Glycine transporters are interesting therapeutic targets as they play significant roles in glycinergic and glutamatergic systems. The search for new selective inhibitors of particular types of glycine transporters (GlyT-1 and GlyT-2) with beneficial
Externí odkaz:
https://doaj.org/article/890de8ecc15048719689868666343d09
Autor:
Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 169 (2021)
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the enzymes acetylcholinesterase and butyrylcholin
Externí odkaz:
https://doaj.org/article/14ec8548063b41f1b2435717dd3df135
Autor:
Kamila Czarnecka, Małgorzata Girek, Przemysław Wójtowicz, Paweł Kręcisz, Robert Skibiński, Jakub Jończyk, Kamil Łątka, Marek Bajda, Anna Walczak, Grzegorz Galita, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk, Paweł Szymański
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3765 (2020)
A series of new tetrahydroacridine and 3,5-dichlorobenzoic acid hybrids with different spacers were designed, synthesized, and evaluated for their ability to inhibit both cholinesterase enzymes. Compounds 3a, 3b, 3f, and 3g exhibited selective butyry
Externí odkaz:
https://doaj.org/article/e31425d6c23c4996a96f2fb20d8acfc8
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 102 (2020)
The norepinephrine transporter (NET) is one of the monoamine transporters. Its X-ray crystal structure has not been obtained yet. Inhibitors of human NET (hNET) play a major role in the treatment of many central and peripheral nervous system diseases
Externí odkaz:
https://doaj.org/article/bb45e7410fe84a788dd9994067dbfb14
Autor:
Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk, Paweł Szymański
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 498 (2019)
Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-N
Externí odkaz:
https://doaj.org/article/52f25dba3d1c435db76e52cef27aa56f
Autor:
Barbara Malawska, Kamil Łątka, Kamil Musilek, Young-Sik Jung, Marek Bajda, Jędrzej Kukułowicz, Jakub Jończyk
Publikováno v:
Biomolecules
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 169, p 169 (2021)
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 169, p 169 (2021)
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the enzymes acetylcholinesterase and butyrylcholin
Autor:
Piotr Szymczyk, Ireneusz Majsterek, Anna Walczak, Paweł Szymański, Marek Bajda, Jacek Kabziński, Jakub Jończyk, Kamila Czarnecka, Robert Skibiński, Przemysław Wójtowicz, Kamil Łątka, Paweł Kręcisz, Grzegorz Galita, Małgorzata Girek
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 3765, p 3765 (2020)
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 3765, p 3765 (2020)
A series of new tetrahydroacridine and 3,5-dichlorobenzoic acid hybrids with different spacers were designed, synthesized, and evaluated for their ability to inhibit both cholinesterase enzymes. Compounds 3a, 3b, 3f, and 3g exhibited selective butyry