New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer’s disease

Autor: Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Piotr Szymczyk, Grzegorz Galita, Jacek Kabziński, Ireneusz Majsterek, Alba Espargaró, Raimon Sabate, Paweł Szymański

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disease. Thus, drugs including donepezil, rivastigmine, and galantamine are not entirely effective in the treatment of this multifactorial disease. The present study evaluates eight

Externí odkaz: https://doaj.org/article/45d56f22c80743759b64fd4e3c5eda6c

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

Autor: Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda

Publikováno v: Biomolecules, Vol 11, Iss 2, p 169 (2021)

Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the enzymes acetylcholinesterase and butyrylcholin

Externí odkaz: https://doaj.org/article/14ec8548063b41f1b2435717dd3df135

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

Autor: Paulina Chałupnik, Alina Vialko, Darryl S. Pickering, Markus Hinkkanen, Stephanie Donbosco, Thor C. Møller, Anders A. Jensen, Birgitte Nielsen, Yasmin Bay, Anders S. Kristensen, Tommy N. Johansen, Kamil Łątka, Marek Bajda, Ewa Szymańska

Publikováno v: Chałupnik, P, Vialko, A, Pickering, D S, Hinkkanen, M, Donbosco, S, Møller, T C, Jensen, A A, Nielsen, B, Bay, Y, Kristensen, A S, Johansen, T N, Łątka, K, Bajda, M & Szymańska, E 2022, ' Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype ', International Journal of Molecular Sciences, vol. 23, no. 15, 8797 . https://doi.org/10.3390/ijms23158797
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8797

Kainate receptors belong to the family of glutamate receptors ion channels, which are responsible for the majority of rapid excitatory synaptic transmission in the central nervous system. The therapeutic potential of kainate receptors is still poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0c4d39338c6b94fd44885c211955e3
https://curis.ku.dk/portal/da/publications/discovery-of-the-first-highly-selective-antagonist-of-the-gluk3-kainate-receptor-subtype(1dd1c2f0-5aea-4a68-b87c-cdb85b250a93).html

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

Autor: Barbara Malawska, Kamil Łątka, Kamil Musilek, Young-Sik Jung, Marek Bajda, Jędrzej Kukułowicz, Jakub Jończyk

Publikováno v: Biomolecules
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 169, p 169 (2021)

Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the enzymes acetylcholinesterase and butyrylcholin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c5fc504a5e6510c2c74242c51a9a56
http://europepmc.org/articles/PMC7912477

Structure Modeling of the Norepinephrine Transporter

Autor: Marek Bajda, Kamil Łątka, Izabella Góral

Publikováno v: Biomolecules
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 102 (2020)

The norepinephrine transporter (NET) is one of the monoamine transporters. Its X-ray crystal structure has not been obtained yet. Inhibitors of human NET (hNET) play a major role in the treatment of many central and peripheral nervous system diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a52c55ba7f8265f406a2a984d4d954