Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kamiel S. K. Artois"'
Publikováno v:
Journal of pain and symptom management. 15(4)
Clinical studies report a low incidence of intestinal side effects with transdermally administered fentanyl (TTS-fentanyl) in comparison with oral morphine. To support these clinical data, analgesic and intestinal effects of both opioids were compare
Autor:
Fred M. Lenaerts, Jozef Vermeire, Carlos J. E. Niemegeers, Frans Awouters, Kamiel S. K. Artois
Publikováno v:
Drug Development Research. 8:279-286
The pharmacological and toxicological effects of loperamide and the N-oxide of loperamide were studied in adult and 19-day-old rats and in 1-day-old pups. In adult rats both orally administered compounds were equipotent and specific antidiarrheals, b
Autor:
Kamiel S. K. Artois, Carlos J. E. Niemegeers, Herman M. R. Hendrickx, Willy van Bruggen, Frans Awouters, Remi E. J. Frederickx, K. H. L. Schellekens
Publikováno v:
Drug Development Research. 8:353-360
R 62 818 and codeine were studied in parallel, mainly in mice and rats. Three levels of analgesia were measured in mice using the hot plate test. ED50 values after sc administration were 6.20, 12.4, and 32.5 mg/kg with R 62 818 and 9.38, 18.7 and 32.
Autor:
Kamiel S. K. Artois, Luc L. J. Canters, Anton Megens, Frans Smeyers, Frans Awouters, Roger C. A. Keersmaekers
Publikováno v:
Drug Development Research. 8:243-250
The gastrokinetic activity of cisapride, bethanechol, domperidone, and metoclopramide was tested in rats and compared with the direct cholinergic activity (induction of salivation and lacrimation in rats) and peripheral and central antidopamine activ