Zobrazeno 1 - 10
of 13 044
pro vyhledávání: '"Kami A"'
Autor:
Derek H. Janssens, Melodie Duran, Dominik J. Otto, Weifang Wu, Yiling Xu, Danielle Kirkey, Charles G. Mullighan, Joanna S. Yi, Soheil Meshinchi, Jay F. Sarthy, Kami Ahmad, Steven Henikoff
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 br
Externí odkaz:
https://doaj.org/article/ea636cfdd021408692f0ace826848682
Autor:
Steven Henikoff, Jorja G. Henikoff, Kami Ahmad, Ronald M. Paranal, Derek H. Janssens, Zachary R. Russell, Frank Szulzewsky, Sita Kugel, Eric C. Holland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract For more than a century, formalin-fixed paraffin-embedded (FFPE) sample preparation has been the preferred method for long-term preservation of biological material. However, the use of FFPE samples for epigenomic studies has been difficult b
Externí odkaz:
https://doaj.org/article/b26b249b67ba49b091b4359f80998da8
Publikováno v:
eLife, Vol 12 (2023)
Spermatogenesis in the Drosophila male germline proceeds through a unique transcriptional program controlled both by germline-specific transcription factors and by testis-specific versions of core transcriptional machinery. This program includes the
Externí odkaz:
https://doaj.org/article/aba693d47dcb4d849f4ec70f21738428
Autor:
Derek H. Janssens, Dominik J. Otto, Michael P. Meers, Manu Setty, Kami Ahmad, Steven Henikoff
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Cleavage Under Targets and Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and single cells. We describe a modified CUT&Tag protocol using a mixture of an antibod
Externí odkaz:
https://doaj.org/article/2363434c279348e18326a59aafb527f7
Autor:
Tao Chen, Xiaolu Wei, Cécile Courret, Min Cui, Lin Cheng, Jing Wu, Kami Ahmad, Amanda M Larracuente, Yikang S Rong
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010351 (2022)
Advances in genomic technology led to a more focused pattern for the distribution of chromosomal proteins and a better understanding of their functions. The recent development of the CUT&RUN technique marks one of the important such advances. Here we
Externí odkaz:
https://doaj.org/article/c45a4176b6d24da1886e3e69eef5f5da
Autor:
Arabi, Dona, Bakhshaliyev, Jafar, Coskuner, Ayse, Madhusudhanan, Kiran, Uckardes, Kami Serdar
Data augmentation is important for improving machine learning model performance when faced with limited real-world data. In time series forecasting (TSF), where accurate predictions are crucial in fields like finance, healthcare, and manufacturing, t
Externí odkaz:
http://arxiv.org/abs/2408.10951
Phishing is one of the most prevalent and expensive types of cybercrime faced by organizations and individuals worldwide. Most prior research has focused on various technical features and traditional representations of text to characterize phishing e
Externí odkaz:
http://arxiv.org/abs/2408.08967
Social bots-automated accounts that generate and spread content on social media-are exploiting vulnerabilities in these platforms to manipulate public perception and disseminate disinformation. This has prompted the development of public bot detectio
Externí odkaz:
http://arxiv.org/abs/2408.06900
Autor:
Kami Ahmad, Steven Henikoff
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009225 (2021)
Development proceeds by the activation of genes by transcription factors and the inactivation of others by chromatin-mediated gene silencing. In certain cases development can be reversed or redirected by mis-expression of master regulator transcripti
Externí odkaz:
https://doaj.org/article/abfbcd07cee24b55be3bd187a758fcfb
Autor:
Hatice S. Kaya-Okur, Steven J. Wu, Christine A. Codomo, Erica S. Pledger, Terri D. Bryson, Jorja G. Henikoff, Kami Ahmad, Steven Henikoff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Understanding gene regulation will require mapping specific chromain features in a small number of cells at high resolution. Here the authors describe CUT&Tag, which uses antibody-mediated tethering of Tn5 transposase to a chromatin protein to genera
Externí odkaz:
https://doaj.org/article/8bb94c477325463b8190bc5a81b1c143