Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kameron V, Kilchrist"'
Autor:
Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. Colazo, Matthew Oliver, Joyce Cheung-Flynn, Colleen M. Brophy, John W. Tierney, Jeffrey S. Isenberg, Kurt D. Hankenson, Kedar Ghimire, Cynthia Lander, Charles A. Gersbach, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide
Externí odkaz:
https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
Autor:
Craig L. Duvall, Rebecca S. Cook, Dana M. Brantley-Sieders, Samantha M. Sarett, Somtochukwu C. Dimobi, Kameron V. Kilchrist, Paula Gonzalez Ericsson, Violeta Sanchez, Donna J. Hicks, Linus H. Lee, Meghan Morrison Joly, Taylor E. Kavanaugh, Meredith A. Jackson, Shan Wang, Thomas A. Werfel
Supplemental Figures S1-9 Supplemental Figure S1 - Table of Oligos Supplemental Figures S2-5 - Scheme of chemical synthesis and characterization of polymers Supplemental Figure S6 - Basic in vitro characterization of si-NPs Supplemental Figure S7 - T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f85d61b430296663b3ff687420dc690
https://doi.org/10.1158/0008-5472.22417482.v1
https://doi.org/10.1158/0008-5472.22417482.v1
Autor:
Craig L. Duvall, Rebecca S. Cook, Dana M. Brantley-Sieders, Samantha M. Sarett, Somtochukwu C. Dimobi, Kameron V. Kilchrist, Paula Gonzalez Ericsson, Violeta Sanchez, Donna J. Hicks, Linus H. Lee, Meghan Morrison Joly, Taylor E. Kavanaugh, Meredith A. Jackson, Shan Wang, Thomas A. Werfel
Small-molecule inhibitors of the mTORC2 kinase (torkinibs) have shown efficacy in early clinical trials. However, the torkinibs under study also inhibit the other mTOR-containing complex mTORC1. While mTORC1/mTORC2 combined inhibition may be benefici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd5836b276f4568e4674c7ef5a94558
https://doi.org/10.1158/0008-5472.c.6509856
https://doi.org/10.1158/0008-5472.c.6509856
Autor:
Seth D. Fortmann, Blake F. Frey, Vidya Sagar Hanumanthu, Shanrun Liu, Andrew Goldsborough, Kameron V. Kilchrist, P. Brent Ferrell, Casey T. Weaver, Maria B. Grant, Robert S. Welner
SUMMARYSingle-cell RNA-sequencing (scRNA-seq) presents an opportunity to deconstruct cellular networks but is limited by the loss of biological information, includingin vivocellular states and phospho-signaling. Herein, we present fixation before dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30993de362dbf311b4e6f87d052c6f1
https://doi.org/10.1101/2023.02.13.528370
https://doi.org/10.1101/2023.02.13.528370
Autor:
Brian Evans, R. Brock Fletcher, J. William Tierney, Eric A. Dailing, Kameron V. Kilchrist, Craig L. Duvall
Publikováno v:
ACS Appl Mater Interfaces
Rapid, facile, and noncovalent cell membrane modification with alkyl-grafted anionic polymers was sought as an approach to enhance intracellular delivery and bioactivity of cationic peptides. We synthesized a library of acrylic acid-based copolymers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcb98a0e753651b61977d9dcfd335fc
https://doi.org/10.1021/acsami.0c13304
https://doi.org/10.1021/acsami.0c13304
Autor:
Kyle M. Garland, Kameron V. Kilchrist, Sema Sevimli, Craig L. Duvall, John T. Wilson, Rebecca S. Cook
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: Nucleic acids have gained recognition as promising immunomodulatory therapeutics. However, their potential is limited by several drug delivery barriers, and there is a need for technologies that enhance intracellular delivery of nucleic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0479080f2cc8a7c36a9f990e80a33138
https://doi.org/10.1007/s12195-019-00571-6
https://doi.org/10.1007/s12195-019-00571-6
Genetically Encoded Split-Luciferase Biosensors to Measure Endosome Disruption Rapidly in Live Cells
Publikováno v:
ACS Sens
Endosomal escape is a critical step in the intracellular delivery of biomacromolecular drugs, but a quantitative, high-throughput study of endosomal-vesicle disruption remains elusive. We designed two genetically encoded split-luciferase turn-on repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec200f6d4557a1484d7e559b3fa5dd4
https://pubmed.ncbi.nlm.nih.gov/32573202
https://pubmed.ncbi.nlm.nih.gov/32573202
Autor:
Mohamed Wehbe, Kameron V. Kilchrist, Plamen P. Christov, Pedro Seber, Craig L. Duvall, Lucinda E. Pastora, Dinh Chuong Nguyen, Christian R. Palmer, Kyle W. Becker, Hayden M. Pagendarm, John T. Wilson, Daniel Shae
Publikováno v:
Adv Healthc Mater
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) hold great therapeutic potential, but their activity is hindered by poor drug-like properties that restrict cytosolic bioavailability. Here, this challenge is addressed thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5fa88dc82b2fed4e1d638b79f13295
https://pubmed.ncbi.nlm.nih.gov/33225632
https://pubmed.ncbi.nlm.nih.gov/33225632
Publikováno v:
ACS Appl Mater Interfaces
Combination therapies consisting of multiple short therapeutic RNAs, such as small interfering RNA (siRNA) and microRNA (miRNA), have enormous potential in cancer treatment as they can precisely silence a specific set of oncogenes and target multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f776c4203cf4f6a8046ee2242b7770a6
https://pubmed.ncbi.nlm.nih.gov/31939276
https://pubmed.ncbi.nlm.nih.gov/31939276
Autor:
Joyce Cheung-Flynn, Brian Evans, Kameron V. Kilchrist, Benjamin Burdette, Craig L. Duvall, Colleen M. Brophy, Eric A. Dailing, Alvin J. Mukalel
Publikováno v:
Journal of Controlled Release. 282:110-119
Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide-polymer nano-polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously-described platform technology for intracellular p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51055b758ed24d1ddffeb5908812c78
https://doi.org/10.1016/j.jconrel.2018.04.045
https://doi.org/10.1016/j.jconrel.2018.04.045