Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kamel Djaout"'
Autor:
Antoine Gedeon, Emilie Yab, Aurelia Dinut, Elodie Sadowski, Estelle Capton, Aurore Dreneau, Julienne Petit, Bruna Gioia, Catherine Piveteau, Kamel Djaout, Estelle Lecat, Anne Marie Wehenkel, Francesca Gubellini, Ariel Mechaly, Pedro M. Alzari, Benoît Deprez, Alain Baulard, Alexandra Aubry, Nicolas Willand, Stéphanie Petrella
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110967- (2024)
Summary: Antimicrobial resistance remains a persistent and pressing public health concern. Here, we describe the synthesis of original triazole-containing inhibitors targeting the DNA gyrase, a well-validated drug target for developing new antibiotic
Externí odkaz:
https://doaj.org/article/f2ede360f26a40f4bc420e0ea048c2c6
Autor:
Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, Alexandre Biela, Stéphanie Slupek, Rudy Antoine, Monika Záhorszká, Francois-Xavier Cantrelle, Xavier Hanoulle, Jana Korduláková, Benoit Deprez, Nicolas Willand, Alain R. Baulard, Marion Flipo
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 335 (2023)
Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is responsible for the death of 1.5 million people each year and the number of bacteria resistant to the standard regimen is constantly increasing. This highlights the need to discove
Externí odkaz:
https://doaj.org/article/8f8af7ff2c8049dca93bfab59dd0da06
Autor:
Kevin Antraygues, Nina Compagne, Francesca Ruggieri, Kamel Djaout, Zainab Edoo, Maxime Eveque, Léo Faïon, Bruna Gioia, Salia Tangara, Anais Vieira Da Cruz, Baptiste Villemagne, Marion Flipo, Alain Baulard, Nicolas Willand
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 388 (2022)
The restrictions posed by the COVID-19 pandemic obliged the French Society for Medicinal Chemistry (Société de chimie thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) to organize their joint autumn symposi
Externí odkaz:
https://doaj.org/article/f47136f0cbd64212844c0704ce3808b7
Autor:
Stéphane Skouloubris, Kamel Djaout, Isabelle Lamarre, Jean-Christophe Lambry, Karine Anger, Julien Briffotaux, Ursula Liebl, Hilde de Reuse, Hannu Myllykallio
Publikováno v:
Open Biology, Vol 5, Iss 6 (2015)
ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacteria
Externí odkaz:
https://doaj.org/article/72786186d0a9436da8dd64ed0d2101d5
Autor:
Marion Flipo, Rosangela Frita, Marilyne Bourotte, María S. Martínez-Martínez, Markus Boesche, Gary W. Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-De Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoit Deprez, David Barros-Aguirre, Modesto J. Remuiñán, Nicolas Willand, Alain R. Baulard
Publikováno v:
Science Translational Medicine. 14
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceee95809e2bca056e0d0c0c3d88cddd
https://doi.org/10.1126/scitranslmed.aaz6280
https://doi.org/10.1126/scitranslmed.aaz6280
Autor:
Martin Moune, Florence Leroux, Léo Faïon, Abdalkarim Tanina, Alexandre Biela, Nicolas Willand, Kevin Bourbiaux, Francois-Xavier Cantrelle, Alain R. Baulard, Laurent Kremer, Catalin Pintiala, Benoit Deprez, Kamel Djaout, René Wintjens, Adrien Herledan, Marion Flipo, Mickaël Blaise, Rosangela Frita, Alexandre Vandeputte, Catherine Piveteau, Xavier Hanoulle
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112440. ⟨10.1016/j.ejmech.2020.112440⟩
European Journal of Medicinal Chemistry, 2020, 200, pp.112440. ⟨10.1016/j.ejmech.2020.112440⟩
European journal of medicinal chemistry, 200
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112440. ⟨10.1016/j.ejmech.2020.112440⟩
European Journal of Medicinal Chemistry, 2020, 200, pp.112440. ⟨10.1016/j.ejmech.2020.112440⟩
European journal of medicinal chemistry, 200
Mycobacterium tuberculosis (M.tb), the etiologic agent of tuberculosis, remains the leading cause of death from a single infectious agent worldwide. The emergence of drug-resistant M.tb strains stresses the need for drugs acting on new targets. Mycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f002ea775c736cf5d49380e21b9b23b6
https://pubmed.ncbi.nlm.nih.gov/32505086
https://pubmed.ncbi.nlm.nih.gov/32505086
Autor:
Alexandre Wohlkonig, David Hot, Sebastien Gagneux, Marc Gitzinger, Julia Feldmann, Mireia Coscolla, Marion Flipo, Nicolas Willand, Martin Moune, Kamel Djaout, Mehdi Kiass, Priscille Brodin, Vincent Delorme, Vanessa Mathys, Rosangela Frita, Karine Soetaert, Benoit Deprez, Ludovic Huot, Nicolas Blondiaux, René Wintjens, Christian Kemmer, Alain R. Baulard, Vincent Trebosc, Camille Locht, Matthieu Desroses, Rudy Antoine
Publikováno v:
Science
Science, 2017, 355 (6330), pp.1206-1211. ⟨10.1126/science.aag1006⟩
Science, American Association for the Advancement of Science, 2017, 355 (6330), pp.1206-1211. ⟨10.1126/science.aag1006⟩
Science, 2017, 355 (6330), pp.1206-1211. ⟨10.1126/science.aag1006⟩
Science, American Association for the Advancement of Science, 2017, 355 (6330), pp.1206-1211. ⟨10.1126/science.aag1006⟩
Countering TB prodrug resistance The arsenal of antibiotics for treating tuberculosis (TB) contains many prodrugs, such as ethionamide, which need activation by normal metabolism to release their toxic effects. Ethionamide is potentiated by small mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ed76165230b886b92d460b21abcf17
https://doi.org/10.1126/science.aag1006
https://doi.org/10.1126/science.aag1006
Autor:
Kamel Djaout, Mireille Regnier, Hubert F. Becker, Hannu Myllykallio, Alice Héliou, Roxane Lestini
Publikováno v:
RNA Biology
RNA Biology, 2017, 14, pp.1075-1085. ⟨10.1080/15476286.2017.1302640⟩
RNA Biology, Taylor & Francis, 2017, 14, pp.1075-1085. ⟨10.1080/15476286.2017.1302640⟩
RNA Biology, 2017, 14, pp.1075-1085. ⟨10.1080/15476286.2017.1302640⟩
RNA Biology, Taylor & Francis, 2017, 14, pp.1075-1085. ⟨10.1080/15476286.2017.1302640⟩
It is only recently that the abundant presence of circular RNAs (circRNAs) in all kingdoms of Life, including the hyperthermophilic archaeon Pyrococcus abyssi, has emerged. This led us to investigate the physiologic significance of a previously obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2090379d2f1bf54b4e9567b642d0e4
https://hal.science/hal-01491132
https://hal.science/hal-01491132
Autor:
Nicolas, Blondiaux, Martin, Moune, Matthieu, Desroses, Rosangela, Frita, Marion, Flipo, Vanessa, Mathys, Karine, Soetaert, Mehdi, Kiass, Vincent, Delorme, Kamel, Djaout, Vincent, Trebosc, Christian, Kemmer, René, Wintjens, Alexandre, Wohlkönig, Rudy, Antoine, Ludovic, Huot, David, Hot, Mireia, Coscolla, Julia, Feldmann, Sebastien, Gagneux, Camille, Locht, Priscille, Brodin, Marc, Gitzinger, Benoit, Déprez, Nicolas, Willand, Alain R, Baulard
Publikováno v:
Science (New York, N.Y.). 355(6330)
Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b1407b30d1895133714a3a485d395d8
https://pubmed.ncbi.nlm.nih.gov/28417989
https://pubmed.ncbi.nlm.nih.gov/28417989
Autor:
Peter B. Madrid, Kamel Djaout, Victoria Katawera, Hannu Myllykallio, Natassja G. Bush, Hubert F. Becker, Sean Ekins, Stephen J. Hearnshaw, Vinayak Singh, Valerie Mizrahi, Yap Boum, Anthony Maxwell, Pauline Bourbon, Jennifer E. Pritchard
Publikováno v:
Scientific Reports
Scientific Reports, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
Scientific Reports, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
There is an urgent need to identify new treatments for tuberculosis (TB), a major infectious disease caused by Mycobacterium tuberculosis (Mtb), which results in 1.5 million deaths each year. We have targeted two essential enzymes in this organism th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763f239d7bcb00db373cb3988355ece1
https://hal.sorbonne-universite.fr/hal-01332296
https://hal.sorbonne-universite.fr/hal-01332296