Zobrazeno 1 - 10
of 504
pro vyhledávání: '"Kamel, Khalili"'
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Despite increasing numbers of aged individuals living with HIV, the mechanisms underlying HIV-associated neurological disorders (HANDs) remain elusive. As HIV-1 pathogenesis and aging are characterized by oxidative stress as well as altered
Externí odkaz:
https://doaj.org/article/9201aa184bf04e72b9175e9dfd58bb38
Autor:
Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo, Kamel Khalili
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated
Externí odkaz:
https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe4
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9734 (2022)
Protein quality control allows eukaryotes to maintain proteostasis under the stress of constantly changing conditions. In this review, we discuss the current literature on PQC, highlighting flaws that must exist for malignancy to occur. At the nidus
Externí odkaz:
https://doaj.org/article/a6c1356214504f7fb6a906a44c490cff
Autor:
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o
Externí odkaz:
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Hang Su, Sruthi Sravanam, Santhi Gorantla, Rafal Kaminski, Kamel Khalili, Larisa Poluektova, Howard E. Gendelman, Prasanta K. Dash
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Detection of latent human immunodeficiency virus type 1 (HIV-1) in “putative” infectious reservoirs is required for determining treatment efficiency and for viral elimination strategies. Such tests require induction of replication competent provi
Externí odkaz:
https://doaj.org/article/fee126ac444942ccaa2826e6a2ae17df
Autor:
Ramona Bella, Rafal Kaminski, Pietro Mancuso, Won-Bin Young, Chen Chen, Rahsan Sariyer, Tracy Fischer, Shohreh Amini, Pasquale Ferrante, Jeffrey M. Jacobson, Fatah Kashanchi, Kamel Khalili
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 275-282 (2018)
We used NOD/SCID mice, also known as NRG, to assess the ability of lentivirus-mediated intravenous delivery of CRISPR in editing the HIV-1 genome from the circulating PBMC engrafts, some of which homed within several animal solid tissues. Lentivirus-
Externí odkaz:
https://doaj.org/article/c3b71237f904449d850998e4e755e66e
Autor:
Valerie D. Myers, MS, Joseph M. McClung, PhD, JuFang Wang, MD, Farzaneh G. Tahrir, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Christopher H. Kontos, MD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 1, Pp 122-131 (2018)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy;
Externí odkaz:
https://doaj.org/article/33d9e8f9566344c191444dc53631ac00
Autor:
Prasanta K. Dash, Chen Chen, Rafal Kaminski, Hang Su, Pietro Mancuso, Brady Sillman, Chen Zhang, Shuren Liao, Sruthi Sravanam, Hong Liu, Emiko Waight, Lili Guo, Saumi Mathews, Rahsan Sariyer, R. Lee Mosley, Larisa Y. Poluektova, Maurizio Caocci, Shohreh Amini, Santhi Gorantla, Tricia H. Burdo, Benson Edagwa, Howard E. Gendelman, Kamel Khalili
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Treatment of HIV-1 ADA -infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (CCR5) and HI
Autor:
John S. Yu, J. Manuel Perez, Roberta A. Gottlieb, Kamel Khalili, Miqin Zhang, Allen M. Andres, Justin S. Michael, Daniel Braas, Yizhou Wang, Ramachandran Murali, Li Aiguo, Hassen Wollebo, Hongqiang Wang, Lincoln A. Edwards, Ken Miyaguchi, Tom M. Thomas
S1. Clinical and molecular profile of gliomas by ASNS status S2. CDKN2A and ASNS KM survival plots by IDH status S3. ASNS copy-number gain compared to ASNS mRNA & protein expression S4. IDH mutation inversely correlate to ASNS copy number gain S5. GS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3940a3168f3c4aa132950083fdc0f2
https://doi.org/10.1158/1541-7786.22517671.v1
https://doi.org/10.1158/1541-7786.22517671.v1
Autor:
John S. Yu, J. Manuel Perez, Roberta A. Gottlieb, Kamel Khalili, Miqin Zhang, Allen M. Andres, Justin S. Michael, Daniel Braas, Yizhou Wang, Ramachandran Murali, Li Aiguo, Hassen Wollebo, Hongqiang Wang, Lincoln A. Edwards, Ken Miyaguchi, Tom M. Thomas
Asparagine synthetase (ASNS) is a gene on the long arm of chromosome 7 that is copy-number amplified in the majority of glioblastomas. ASNS copy-number amplification is associated with a significantly decreased survival. Using patient-derived glioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095bdac82cdf7d36a96ec56ba3662c92
https://doi.org/10.1158/1541-7786.c.6541795.v1
https://doi.org/10.1158/1541-7786.c.6541795.v1