Who needs microtubules? Myogenic reorganization of MTOC, Golgi complex and ER exit sites persists despite lack of normal microtubule tracks.

Autor: Kristien J M Zaal, Ericka Reid, Kambiz Mousavi, Tan Zhang, Amisha Mehta, Elisabeth Bugnard, Vittorio Sartorelli, Evelyn Ralston

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e29057 (2011)

A wave of structural reorganization involving centrosomes, microtubules, Golgi complex and ER exit sites takes place early during skeletal muscle differentiation and completely remodels the secretory pathway. The mechanism of these changes and their

Externí odkaz: https://doaj.org/article/7db8bde66d874ac5a42f5c01bfc7f9f2

Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis

Autor: Hayato Takahashi, Davide Bedognetti, Kazuhiko Igarashi, Kambiz Mousavi, Yuka Kanno, Vittorio Sartorelli, David Clever, Mahadev Rao, Golnaz Vahedi, Kiyoshi Hirahara, Juan Rivera, Francesco M. Marincola, Atsushi Nakamura, Akihiko Muto, Hossein Zare, Rahul Roychoudhuri, Joseph G. Crompton, George A. Punkosdy, Christopher A. Klebanoff, Michael Bonelli, John J. O'Shea, Ena Wang, Hui Liu, Giuseppe Sciumè, Zhiya Yu, Pawel Muranski, Luca Gattinoni, Nicholas P. Restifo, Victoria Hoffmann, Barbara Dema

Publikováno v: Nature

Diverse autoimmune and allergic diseases are associated with polymorphisms in a locus encoding the transcription factor BACH2; here, BACH2 is shown to be a broad regulator of immune activation that stabilizes the differentiation of Treg cells by repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f649de153bd7746022f6cdfb1e5e9f8b
http://europepmc.org/articles/PMC3710737

Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injury

Autor: Kambiz Mousavi, Wilson Miranda, David J. Parry

Publikováno v: American Journal of Physiology-Cell Physiology. 283:C950-C959

Neonatal sciatic nerve crush results in a sustained reduction of the mass of both extensor digitorum longus (EDL) and soleus (SOL) muscles in the rat. Type IIB fibers are selectively lost from EDL. We have investigated the effects of ciliary neurotro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0556106667a3d0830c7df25beff320c5
https://doi.org/10.1152/ajpcell.00081.2002

eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci

Autor: Assia Derfoul, Vittorio Sartorelli, Gordon L. Hager, Lars Grøntved, Hossein Zare, Gustavo Gutierrez-Cruz, Kambiz Mousavi, Stefania Dell'Orso

Publikováno v: Mousavi, K, Zare, H, Dell'orso, S, Grøntved, L, Gutierrez-Cruz, G, Derfoul, A, Hager, G L & Sartorelli, V 2013, ' eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci ', Molecular Cell, vol. 51, no. 5, pp. 606-17 . https://doi.org/10.1016/j.molcel.2013.07.022

Summary Transcription factors and DNA regulatory binding motifs are fundamental components of the gene regulatory network. Here, by using genome-wide binding profiling, we show extensive occupancy of transcription factors of myogenesis (MyoD and Myog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e719fd9121f83f24e351f14160af25
https://portal.findresearcher.sdu.dk/da/publications/152acbdc-3e6f-470d-9989-1e6f0f94bd9c

Polycomb protein Ezh1 promotes RNA polymerase II elongation

Autor: A. Hongjun Wang, Kambiz Mousavi, Vittorio Sartorelli, Hossein Zare

Publikováno v: Molecular cell. 45(2)

Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f885c7e3c527529292b1f31ea00f18c9
https://pubmed.ncbi.nlm.nih.gov/22284674