PrP turnover in vivo and the time to effect of prion disease therapeutics.

Autor: Corridon TL; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., O'Moore J; Weissman Hood Institute, Great Falls, MT, 59405, USA., Lian Y; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Laversenne V; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Noble B; Ionis Pharmaceuticals, Carlsbad, CA, 92010, USA., Kamath NG; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Serack FE; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Shaikh AB; Charles River Laboratories, Worcester, MA, 01605, USA., Erickson B; IQ Proteomics, Framingham, MA, 01702, USA., Braun C; IQ Proteomics, Framingham, MA, 01702, USA., Lenz K; Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Howard M; Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Chan N; Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Reidenbach AG; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Cabin DE; Weissman Hood Institute, Great Falls, MT, 59405, USA., Vallabh SM; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA.; Prion Alliance, Cambridge, MA, 02139, USA., Grindeland A; Weissman Hood Institute, Great Falls, MT, 59405, USA., Oberbeck N; Gate Bio, Brisbane, CA, 94005, USA., Zhao HT; Ionis Pharmaceuticals, Carlsbad, CA, 92010, USA., Minikel EV; Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA.; Prion Alliance, Cambridge, MA, 02139, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 14. Date of Electronic Publication: 2024 Nov 14.