Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kamalesh K. Sharma"'
Autor:
Nima Sharifi, Richard J. Auchus, Jiayan Liu, Jennifer Yoshimoto, Kai-Hsiung Chang, Kamalesh K. Sharma, Kristen Evaul, Rui Li
PDF file - 61K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b85738ed73ff93337eece6c0c2ae16
https://doi.org/10.1158/1078-0432.22455974
https://doi.org/10.1158/1078-0432.22455974
Autor:
Nima Sharifi, Richard J. Auchus, Jiayan Liu, Jennifer Yoshimoto, Kai-Hsiung Chang, Kamalesh K. Sharma, Kristen Evaul, Rui Li
Purpose: Treatment with abiraterone (abi) acetate prolongs survival in castration-resistant prostate cancer (CRPC). Resistance to abi invariably occurs, probably due in part to upregulation of steroidogenic enzymes and/or other mechanisms that sustai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868d738e8b027c1a485d62e428f58bc8
https://doi.org/10.1158/1078-0432.c.6523172.v1
https://doi.org/10.1158/1078-0432.c.6523172.v1
Autor:
Nima Sharifi, Richard J. Auchus, Jiayan Liu, Jennifer Yoshimoto, Kai-Hsiung Chang, Kamalesh K. Sharma, Kristen Evaul, Rui Li
PDF file - 237K, Structures and synthetic scheme for abi and delta4-abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd1142cd84a3a38b4abe2fd67791725
https://doi.org/10.1158/1078-0432.22455977
https://doi.org/10.1158/1078-0432.22455977
Autor:
H. Eric Xu, Daniel L. Motola, David J. Mangelsdorf, Kamalesh K. Sharma, Zhu Wang, John M. Hawdon, Xin Gao, Richard J. Auchus, James B. Lok, Aoife Conneely, Kelly Suino-Powell, X. Edward Zhou, Steven A. Kliewer, Craig M. Ogata
Publikováno v:
Proceedings of the National Academy of Sciences. 106:9138-9143
Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1 billion people. The molecular mechanisms governing infection are poorly understood. Here, we report that an evolutionarily conserved nuclear hormone r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b54a083cca1538c368e87c6ce0e0ca5
https://doi.org/10.1073/pnas.0904064106
https://doi.org/10.1073/pnas.0904064106
Autor:
Wenqi Yang, William B. Campbell, Kasem Nithipatikom, John R. Falck, L. Manmohan Reddy, Bhavani Sangras, Kamalesh K. Sharma, Kathryn M. Gauthier
Publikováno v:
Hypertension. 45:681-686
5,6-Epoxyeicosatrienoic acid (5,6-EET) is a cytochrome P450 epoxygenase metabolite of arachidonic acid that causes vasorelaxation. However, investigations of its role in biological systems have been limited by its chemical instability. We developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173e2ca44184ec8c243b9de83e83456f
https://doi.org/10.1161/01.hyp.0000153790.12735.f9
https://doi.org/10.1161/01.hyp.0000153790.12735.f9
Publikováno v:
Archives of Biochemistry and Biophysics. 429:50-59
Human 17beta-hydroxysteroid dehydrogenases (17betaHSDs) catalyze the interconversion of weak and potent androgen and estrogen pairs. Although the reactions using purified enzymes can be driven in either direction, these enzymes appear to function uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c18db05bd5f344ee3235597d5d6836
https://doi.org/10.1016/j.abb.2004.05.023
https://doi.org/10.1016/j.abb.2004.05.023
Autor:
Kamalesh K. Sharma, Y. Krishna Reddy, K. Malla Reddy, Kathryn M. Gauthier, Christine Deeter, William B. Campbell, Sarah B. Hittner, P. Srinagesh Kumar, John R. Falck, U. Murali Krishna
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H337-H349
Epoxyeicosatrienoic acids (EETs) are endothelium-derived eicosanoids that activate potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 analogs of 14,15-EET on vascular tone to determine the structural features required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1036384a14e6092e483647c474cd36a2
https://doi.org/10.1152/ajpheart.00831.2001
https://doi.org/10.1152/ajpheart.00831.2001
Publikováno v:
Synthetic Communications. 32:1557-1562
2H-3-Chromenecarbaldehydes (3a–e) on reaction with malononitrile in the presence of piperidine gave 9-amino-6H- benzo[c]chromene-8,10-dicarbonitriles (4a–e) in good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d64e34a6fb5afd7cd9fffd167b11a1
https://doi.org/10.1081/scc-120004146
https://doi.org/10.1081/scc-120004146
Autor:
Hwei Ming Peng, David A. Stidd, Susan Matthew, Richard J. Auchus, Jennifer Yoshimoto, Kamalesh K. Sharma, Yishan Zhou, Francis K. Yoshimoto
Publikováno v:
Biochemistry. 51(36)
The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydroxylase) catalyze progesterone hydroxylation at one or more sites within a 2 A radius. We probed their hydrogen atom abstraction mechanisms and regioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d43591cf35232a85adc4e78c50dfa1
https://pubmed.ncbi.nlm.nih.gov/22873692
https://pubmed.ncbi.nlm.nih.gov/22873692
Autor:
Richard J. Auchus, Manisha Gupta, Kamalesh K. Sharma, Christopher R. Dwyer, Keliang Xu, Zhu Wang, Dario Mizrachi
Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2)1 catalyzes the 21-hydroxylation of progesterone (P4) and its preferred substrate 17α-hydroxyprogestrone (17OHP4). CYP21A2 activities, which are required for cortisol and aldosterone biosynth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929ef424d32e682528de378820acbe87
https://europepmc.org/articles/PMC3165045/
https://europepmc.org/articles/PMC3165045/