Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Kamaleddin Haj Mohammad Ebrahim Tehrani"'
1
Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance
Autor: Kamaleddin Haj Mohammad Ebrahim Tehrani, Nora C. Brüchle, Nathaniel I. Martin, Ioli Kotsogianni, Vida Mashayekhi, Matthijs J. van Haren, Nicola Wade
Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-a European Journal, 27(11), 3806-3811
Chemistry – A European Journal
Chemistry-A European Journal, 27(11), 3806-3811
The increasing prevalence of metallo‐β‐lactamase (MBL)‐expressing bacteria presents a worrying trend in antibiotic resistance. MBLs rely on active site zinc ions for their hydrolytic activity and the pursuit of MBL‐inhibitors has therefore i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0881b0239761b1f74359d4ab15b54415
http://europepmc.org/articles/PMC7986777
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2
Mechanistic investigations of metallo-β-lactamase inhibitors
Autor: Matthijs J. van Haren, Vida Mashayekhi, Nathaniel I. Martin, Nora C. Brüchle, Nicola Wade, Kamaleddin Haj Mohammad Ebrahim Tehrani
Publikováno v: ChemMedChem, 16(10), 1651-1659. Wiley
Chemmedchem
ChemMedChem, 16(10), 1651-1659
ChemMedChem
Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems. At present there are no clinically approved MBL inhibitors, and in order t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2feca5b0a988f4adbd262ffe6e73003
https://hdl.handle.net/1887/3264246
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3
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases
Autor: Gerard J. P. van Westen, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Kamaleddin Haj Mohammad Ebrahim Tehrani, Nicola Wade, Diego Pesce, Nathaniel I. Martin, Matthijs J. van Haren, Vida Mashayekhi
Publikováno v: Journal of Medicinal Chemistry, 64(13), 9141-9151
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 64(13), 9141-9151. American Chemical Society (ACS)
Journal of Medicinal Chemistry, 64(13), 9141–9151
Journal of Medicinal Chemistry 64 (2021) 13
In an attempt to exploit the hydrolytic mechanism by which β-lactamases degrade cephalosporins, we designed and synthesized a series of novel cephalosporin prodrugs aimed at delivering thiol-based inhibitors of metallo-β-lactamases (MBLs) in a spat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7434e99ae6bc87c2d7340a7b52f5cd0
https://research.wur.nl/en/publications/novel-cephalosporin-conjugates-display-potent-and-selective-inhib
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4
Small molecule carboxylates inhibit metallo-β-lactamases and resensitize carbapenem-resistant bacteria to meropenem
Autor: Nicola Wade, Nora C. Brüchle, Diego Pesce, Vida Mashayekhi, Nathaniel I. Martin, Kamaleddin Haj Mohammad Ebrahim Tehrani, Matthijs J. van Haren
Publikováno v: ACS Infectious Diseases, 6(6), 1366-1371
ACS Infectious Diseases
ACS Infectious Diseases 6 (2020) 6
In the search for new inhibitors of bacterial metallo-β-lactamases (MBLs), a series of commonly used small molecule carboxylic acid derivatives were evaluated for their ability to inhibit New Delhi metallo-β-lactamase (NDM)-, Verona integron-encode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fe91c7aa7e561e1695bd2fb527a413
http://hdl.handle.net/1887/3134866
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5
Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1
Autor: Alejandro Prats Luján, Kamaleddin Haj Mohammad Ebrahim Tehrani, Vida Mashayekhi, Matthijs J. van Haren, Gerrit J. Poelarends, Nora C. Brüchle, Haigen Fu, Nathaniel I. Martin
Publikováno v: Chemical Communications
Chemical Communications, 56(20), 3047-3049. ROYAL SOC CHEMISTRY
Chemical Communications, 56(20), 3047-3049
A series of aminocarboxylic acid analogues of aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) were chemoenzymatically synthesized via the addition of various mono- and diamine substrates to fumaric acid catalyzed by the en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30b878229b8a843056affc75c86feb1
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6
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7
Autor: Walter Fast, Zishuo Cheng, M. Rachel Mehaffey, Hao Yang, Nathaniel I. Martin, Richard C. Page, Zachary B. Adkins, Jennifer S. Brodbelt, Alexander Bergstrom, Jessica E. Hill, Mia L. Burnett, Michael W. Crowder, Kamaleddin Haj Mohammad Ebrahim Tehrani, Gerard D. Wright, David L. Tierney, Robert A. Bonomo, Andrew Katko, Mahesh Aitha
Publikováno v: ACS Infectious Diseases
ACS Infectious Diseases, 4(2), 135-145
Metallo-β-lactamases (MBLs) are a growing threat to the continued efficacy of β-lactam antibiotics. Recently, aspergillomarasmine A (AMA) was identified as an MBL inhibitor, but the mode of inhibition was not fully characterized. Equilibrium dialys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68f5b06324183cd1e04103cf8ef56ed
https://doi.org/10.1021/acsinfecdis.7b00106
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7
De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria
Autor: Thomas M. Wood, Małgorzata Śleszyńska, Nathaniel I. Martin, Antoni P. A. Hendrickx, Eefjan Breukink, Peter 't Hart, Rob J. L. Willems, Inmaculada Rentero Rebollo, Kamaleddin Haj Mohammad Ebrahim Tehrani, Roel M. van Harten
Publikováno v: Chemical Science, 8(12), 7991. Royal Society of Chemistry
Chemical Science, 8(12), 7991-7997
Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fada92c0189fcf3e891b27e8162673
https://doi.org/10.1039/c7sc03413j
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8
Synthesis and antibacterial activity of Schiff bases of 5-substituted isatins
Autor: Farzad Kobarfard, Maryam Hashemi, Kamaleddin Haj Mohammad Ebrahim Tehrani, Shohreh Mohebbi, Maryam Hassan
Publikováno v: Chinese Chemical Letters. 27:221-225
Based on the existing reports on the bioactive isatin derivatives, a number of Schiff bases were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and their structures were confirmed using spectroscopic methods such as NM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94db9d66325cff92fba348ed1298b152
https://doi.org/10.1016/j.cclet.2015.10.027
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9
A new tool to reveal bacterial signaling mechanisms in antibiotic treatment and resistance
Autor: Clement M Potel, Miao-Hsia Lin, Albert J. R. Heck, Nathaniel I. Martin, Kamaleddin Haj Mohammad Ebrahim Tehrani, Simone Lemeer
Publikováno v: Molecular & Cellular Proteomics
Molecular and Cellular Proteomics, 17(12), 2496-2507
Molecular and Cellular Proteomics
The rapid emergence of antimicrobial resistance is a major threat to human health. Antibiotics modulate a wide range of biological processes in bacteria and as such, the study of bacterial cellular signaling could aid the development of urgently need
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196531c74638483e8c7e045b55b11d90
https://doi.org/10.1074/mcp.ra118.000880
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10
β-lactam/β-lactamase inhibitor combinations: an update
Autor: Nathaniel I. Martin, Kamaleddin Haj Mohammad Ebrahim Tehrani
Publikováno v: MEDCHEMCOMM, 9, 1439-1456
MEDCHEMCOMM
MedChemComm
Antibiotic resistance caused by β-lactamase production continues to present a growing challenge to the efficacy of β-lactams and their role as the most important class of clinically used antibiotics. In response to this threat however, only a handf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69846b89ad5c76c592e136d91b9ed199
https://doi.org/10.1039/c8md00342d
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