Essential role of pre-existing humoral immunity in TLR9-mediated type I IFN response to recombinant AAV vectors in human whole blood

Autor: Nada S. Alakhras, Christopher A. Moreland, Li Chin Wong, Priyam Raut, Sid Kamalakaran, Yi Wen, Robert W. Siegel, Laurent P. Malherbe

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Recombinant adeno-associated virus (AAV) vectors have emerged as the preferred platform for gene therapy of rare human diseases. Despite the clinical promise, host immune responses to AAV vectors and transgene remain a major barrier to the developmen

Externí odkaz: https://doaj.org/article/5d526ac1f027445c881a5c370ba6217e

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Studying banded spherulites in HDPE by electron microscopy

Autor: Tantry, Sudha, Anantharaman, Dhanabalan, Thimmappa, B.H.S., Kamalakaran, Radha

Publikováno v: In Polymer Testing September 2020 89

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

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Publikováno v: In Neuron 21 March 2018 97(6):1267-1288

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